Switch Lab

#ProAgg26 is coming!

Abstract submission is open - invitations to register will be sent after abstract review, making sure all selected participants can attend.

All info: vibbio.tech/ProAgg26

We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social

This weekend temperatures soared... perfect for the 4th CBD-CCB-NERF Beachvolley tournament. And here's the Switch team in action - well done to @ramonduran.bsky.social
@brajabandhu.bsky.social‬ Alex, Sara, Fleur and Wouter!

Last week Switchie Valeria successfully defended her PhD! Congratulations, Dr Narykina, and all our best wishes for the future. We'll miss you!

Congratulations to Switchies @ramonduran.bsky.social & Gemma Martinez-Rivas on securing Post Doc funding from ‪@fwovlaanderen.bsky.social‬. Gemma's project focuses on AL amyloidosis and Ramon will look at co-translational protein folding (and more) during ageing. Wishing them much success!

This promises to be a great meeting!

Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism - Nature Communications Protein biosynthesis is a major target of existing antibiotics that inhibit the efficiency or fidelity of the bacterial ribosome. Here, the authors show that a synthetic peptide displays bactericidal ...

Drug-resistant bacteria are a global threat. In our study, we reveal a new antibacterial strategy: a peptide that disrupts protein homeostasis by causing co-translational aggregation, killing a wide range of pathogenic bacteria 🦠💥.

📄 Full paper here: www.nature.com/articles/s41...

Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation - Nature Communications During vectorial protein translation, native interactions are temporarily unsatisfied. Here, authors introduce “Native Fold Delay”, integrating protein topology with translation kinetics to quantify t...

Most proteins fold co-translationally, but what if key residues aren’t available in time? Our new study introduces Native Fold Delay, a metric that links protein topology and translation rates to quantify folding delays. ⏳
Read more here www.nature.com/articles/s41...

And another new team member :-) Welcoming Gerd Van der Hoeven to Switch, as a research technician. Our heterotypics team is at full strength!

The new year starts with new Switchies :-) Very happy to welcome post doc Kevin Muwonge to our lab - Kevin joins our team working on heterotypic amyloid interactions.