Vishwanath Sivalingam

Rad23B delays Ataxin-3 liquid-to-solid phase transition through heterotypic buffering
www.sciencedirect.com/science/arti...

Quantifying protein unfolding kinetics with a high-throughput microfluidic platform Even after folding, proteins transiently sample unfolded or partially unfolded intermediates, and these species are often at risk of irreversible alteration ( e.g. via proteolysis, aggregation, or pos...

Quantifying protein unfolding kinetics with a high-throughput microfluidic platform

www.biorxiv.org/content/10.1...

Quantitation and Error Measurements in Dose–Response Curves

If you work in drug discovery and you read one thing this weekend, make it this exceptional J Med Chem editorial. Hits on almost every blessed thing I’ve tweetorialized over the last several years.

Quantitation and Error Measurements in Dose–Response Curves

A schematic picture of a cell, showing condensates, a nucleus and the cytoskeleton.

We wrote a review on the "Physics of droplet regulation in biological cells": arxiv.org/abs/2501.13639 Beside the basic #physics of phase separation, we discuss three aspects that separate cellular from traditional droplets:

Pylustrator got some love on Twitter, and I thought folks here would appreciate it too. 🖌️✨ Here's how it can help make your Matplotlib plots stunning and reproducible: 👇

Tidyplots makes it easy to generate publication-ready plots for scientific papers 🚀

tidyplots.org

Tidyplots empowers life scientists with easy code-based data visualization Code-based data visualization is a crucial tool for understanding and communicating experimental findings while ensuring scalability and reproducibility. However, complex programming interfaces pose a...

Tidyplots empowers life scientists with easy code-based data visualization

www.biorxiv.org/content/10.1...

Discovery and significance of protein-protein interactions in health and disease From identifying individual protein-protein interactions (PPIs) in the 1980s to characterizing whole-cell interactomes more recently, approaches for identifying cellular PPIs have opened the way for u...

Discovery and significance of protein-protein interactions in health and disease

www.cell.com/cell/fulltex...

Amyloid is everywhere, but new treatments could stop the toxic build up - Nature Biotechnology Amyloid deposits are present in the brains of cognitively impaired individuals, but also accumulate throughout the body. Some biotechs aim to keep these misfolded proteins in check to treat a range of...

Amyloid is everywhere, but new treatments could stop the toxic build up

www.nature.com/articles/s41...