Vienna Airway Lab

Study comparing nasal brushing samples directly to nasal tissue reveals that while brushing effectively captures surface cells, it misses deeper immune cells and shows different T-cell responses, underscoring the need to choose sampling methods based on specific research questions.
🔗 ino.to/9xnsacb

Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling @ellenfoxman.bsky.social @yalepress.bsky.social
www.cell.com/cell-press-b... @cellpressblue.bsky.social

IL-2 synergizes with proinflammatory type 3 inducers to amplify mixed type 2-type 3 inflammation in nasal polyps

#CRSwNP #Immunology
🔗 ino.to/ZDIEPXT

Two Distinct Transcriptional Subtypes of Severe Type 2 Asthma in NSAID‐Exacerbated Respiratory Disease The study included 27 patients with N-ERD and severe asthma. A cluster analysis with 116 variables was performed. Two clusters were identified: cluster 1 (n = 10), T2-low with low sputum GATA3 expres...

Using sputum gene expression, researchers identified two distinct subtypes of NSAID-exacerbated respiratory disease, distinguished by GATA3 levels and inflammatory profiles, suggesting GATA3 could be a key biomarker for differentiating these patients.
#CRS #asthma #Immunology

🔗 ino.to/UQb8tc7

Only 2 months to go! 📅

On April 23, 2026, the international Awareness Day for CRSwNP takes place. We invite you to a free patient info evening in Vienna.
Learn about symptoms, causes & modern therapies + expert Q&A.

Register:
hno.meduniwien.ac.at/ueber-uns/ev...
#MedUniWien #EUFOREA

Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling - Nature Immunology Belderbos and colleagues generate a multimodal single-cell atlas of healthy human bone marrow spanning infancy, adolescence and adulthood.

Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling
www.nature.com/articles/s41... @natimmunol.nature.com

Welcoming bachelor’s students Sarah (FH Tulln) and Carina (University of Vienna) to our lab for their placements 🔬🧫
Thrilled to have you both! 💪✨

#Immunology #research #mentoring #MedUniWien #ViennaAirwayLab

EAACI Task Force Report highlights Chronic rhinosinusitis (CRS) & #asthma, especially severe N-ERD, are linked by type 2 inflammation. While transformative #biologics target this, personalized treatments and more trials are needed to optimize care.
#CRS #Immunology

🔗 ino.to/fW9sKQh

Microarrayed Allergen Molecules Distinguish IgE Sensitisation to Blomia tropicalis and Dermatophagoides pteronyssinus This study established a microarray containing a representative panel of purified Blo t and Der p allergens for the identification of patients sensitised to Blo t and/or Der p. Results indicate that ...

New allergen chip precisely maps immune responses to tropical (Blo t) & temperate (Der p) dust mites, enabling targeted diagnosis and paving the way for personalized immunotherapy. Congratulations to the authors 👏

#Allergy #Immunology #MedUniWien

🔗 ino.to/iDbGW9P

Real‐World Effectiveness of Mepolizumab in Patients With Chronic Rhinosinusitis With Nasal Polyps: Findings From the European CRS Outcome Registry (CHRINOSOR) Background The SYNAPSE phase 3 study demonstrated that mepolizumab significantly improves nasal polyp score (NPS), quality of life and symptom severity in patients with chronic rhinosinusitis with n...

📣Thrilled to share our pan-European collaboration results: mepolizumab delivers progressive,real-world benefits in #CRSwNP! Nearly 50% achieved a deep composite response at 1 year, proving the power of staying the course.A huge team effort!
#biologics #RealWorldEvidence
🔗 dx.doi.org/10.1002/clt2...

AlphaGenome is out in @nature.com today along with model weights! 🧬

📄 Paper: www.nature.com/articles/s41...

💻 Weights: github.com/google-deepm...

Getting here wasn’t a straight path. We discussed the story behind the model, paper & API in the following roundtable: youtu.be/V8lhUqKqzUc

People allergic to grass pollen 🤧 are more often also sensitised to various fungi. Airborne fungi can temporarily shift the nasal mycobiome, and spores from common environmental fungi can weaken the nasal barrier and trigger immune responses 🔥.
#Immunology #Allergy

🔗 ino.to/tLOjf5L

🤩 Thrilled our research is a JACI Editor's Choice! 🎉
We identified distinct protein fingerprints (GDNF/CLC) for noninvasive diagnosis of chronic rhinosinusitis with nasal polyps (DOI: 10.1016/j.jaci.2025.08.025)🔬
#CRS #PrecisionMedicine #Proteomics #Immunology

🔗 ino.to/wu9XyBl

Skin tape strips identify age-specific immune, metabolic and barrier dysregulation signatures in children, adolescents, and adults with allergic asthma.
#Immunology #asthma #Biomarkers #TranslationalResearch

🔗 ino.to/lMRHI0I

A Walk in the Park: Influence of Natural Co-Exposure to Grass Pollen and Fungal Spores on Nasal Mycobiome and Cytokine Responses - PubMed Frequent co-exposure to fungal spores and grass pollen may increase the chance of acquiring a co-sensitisation to both allergens. Environmental fungi interact with and transitorily change the local mycobiome. Under co-exposure, fungal spores induce nasal inflammation and foster immune responses to o …

Picnic in the park: beautiful lawn, air—and pollen plus fungal spores teaming up to stir up your nose 🤧🌼
Now backed by well-done research on natural co-exposure (pubmed.ncbi.nlm.nih.gov/41545035/).
Picnic indoors avoids the allergens…
but for some unknown reason, the food just tastes better outside.

Scientists have mapped the hidden diversity of #eosinophils across the body, revealing that their unique identities and functions are dictated by how long they reside in specific tissues, providing a new toolkit to study their roles in health and disease.

#Immunology #ImmunoSky

🔗 ino.to/tlubGEn

Interpretable inflammation landscape of circulating immune cells - Nature Medicine Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.
https://www.nature.com/articles/s41591-025-04126-3

Scientists have discovered two previously unknown subtypes of human basophils 🎉 The first comprehensive single-cell map 🧬 of these cells is now an open resource 🖥️ for understanding diseases like allergies 🤧
#Immunology #allergy #singlecellbiology #CITEseq

🔗 ino.to/qtQM0SI

In vivo detection of immune responses via cytokine activity labeling @cellcellpress.bsky.social @harvardmed.bsky.social
www.cell.com/cell/fulltex...

Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation Immunoglobulin M has other functions beyond antibody class switching that have implications in asthma treatment.

Novel study reveals that IgM drives airway hyperresponsiveness in allergic asthma via the Baiap2l1 pathway in human airway smooth muscle, uncovering a novel target for future therapies 💊

#Immunology #asthma #Th2

🔗 doi.org/10.7554/eLif...

Our lab's Christmas🎄 outing was pure magic! ⛄️ From competitive curling 🥌, to mulled wine 🧉 at the stunning Schönbrunn Christmas market, to a feast at a lovely Greek taverna. The perfect festive blend of teamwork & cheer.🎉

#ViennaAirwayLab #LabLife #ViennaChristmas #TeamBuilding

It was a true pleasure contributing to and collaborating on this excellent piece of work 🙌. Congratulations 👏

Screenshot of the Title: The impact of Climate Change on the Urban Tree Ailanthus altissima: insights from more than decades of Pollen data in Vienna (Austria). Authors: Maximilian Bastl, Katharina Bastl, Karen Kölzer, Marija Aleksic, Christina Morgenstern and Martin Schepelmann

Insights from the first long-term dataset of Ailanthus pollen: temperature and sunshine hours as major drivers of climate change on pollination intensity.

Study of #pollenservicewien and @viennaairwaylab.bsky.social and others @meduniwien.ac.at
⬇️
www.mdpi.com/2223-7747/14...

Tolerance to ferroptosis facilitates lipid metabolism and pathogenic type 2 immunity in allergic airway inflammation @cp-immunity.bsky.social @labwilhelm.bsky.social
www.cell.com/immunity/ful...

Dominance of IL-5 and CCL17 in nasal cytokine profiles of children with type 2 inflammation 🔥
#Immunology #type2inflammation #asthma #allergy

🔗 www.jacionline.org/article/S009...

A vaccine targeting human IgE induces long-term protection against anaphylaxis in humanized mice A conjugate vaccine targeting human IgE induces long-term production of neutralizing antibodies and protects against anaphylaxis in humanized mice.

New study: an IgE-targeting vaccine produced antibodies that protected mice from anaphylaxis without weakening their immune response to a helminth infection. Big potential for safer allergy prevention. 🔬🧬
www.science.org/doi/10.1126/...
#Immunosky

🎉 Our new study maps the real-time inflammatory dynamics 🔥of aspirin challenge in N-ERD patients. We further reveal the direct modulatory effect of #dupilumab 💊 on these acute reactions for the first time! 🧪 @cea01.bsky.social

#asthma #CRSwNP #Immunology #Type2Inflammation

🔗 ino.to/7UpJJqA

Aberrant ceramide accumulation fuels eosinophilic inflammation by promoting Eosinophil Extracellular Traps (EET) formation and release in Chronic rhinosinusitis with nasal polyps (CRSwNP)
#CRSwNP #inflammation #ROS #oxidativestress

🔗 ino.to/hBsxjbm

Long‐Term Effect of Allergen Immunotherapy in Responder Local Allergic Rhinitis Patients: Symptom Control, and Prevention of Asthma and Allergic Sensitizations LAR patients who respond to AIT during the first year and are treated for two more years continue improving (less symptoms and medication intake) during the following seven years. AIT prevents the on...

Long‐Term Effect of Allergen Immunotherapy in Responder Local Allergic Rhinitis Patients: Symptom Control, and Prevention of Asthma and Allergic Sensitizations
#Immunology #allergy #rhinitis #immunotherapy #asthma

🔗 ino.to/CKPDLAC

Tumour-reactive heterotypic CD8 T cell clusters from clinical samples Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.

As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells.

#immunology
#science
#tumor
#immunotherapy

buff.ly/pETJPEH