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@nklkhlr

Postdoc at Heidelberg University in the lab of Britta Velten working on ML for spatial omics data ๐Ÿ  nklkhlr.github.io ๐Ÿ’ป github.com/nklkhlr

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11.01.2025
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Latest posts by @nklkhlr

๐Ÿ“ข Job alert (3/3)

๐ŸŒฑ The goal is to build a team with diverse backgrounds, so please donโ€™t be discouraged if you donโ€™t tick all the boxes!

www.leibniz-lsb.de/fileadmin/do...
www.leibniz-lsb.de/fileadmin/do...

20.02.2026 19:51 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

๐Ÿ“ข Job alert (2/3)

๐Ÿ’ผ๐Ÿงฌ Iโ€™m currently looking for two motivated PhD students to start around May. If you or anyone you know is excited about graphs, (probabilistic) ML, omics data, and applications to food biology, please apply/reach out and spread the word.

20.02.2026 19:51 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

๐Ÿ“ข Job alert (1/3)

In April, I will be starting my research group at the Leibniz Institute for Food Systems Biology at TUM.

๐Ÿ’ป๐Ÿฃ Our work will focus on developing computational methods to integrate and analyze omics data in a food biology context

20.02.2026 19:51 ๐Ÿ‘ 4 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Weโ€™re excited to be back at the Heidelberg spatial omics seminar series today ๐Ÿ˜

10.02.2026 10:06 ๐Ÿ‘ 4 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

I think that is the core of the peer-review crisis. If we were to only do peer review of the scientific work that is both important enough and non-trivial, we would all save a lot of time. It will obviously be a challenge to decide what needs to be reviewed, I acknowledge that.

28.01.2026 13:33 ๐Ÿ‘ 8 ๐Ÿ” 3 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 1
View from the hotel room

View from the hotel room

Poster session 2024, with Valentina Boeva, Constantin Ahlmann-Eltze and others

Poster session 2024, with Valentina Boeva, Constantin Ahlmann-Eltze and others

Wednesday afternoon hike incl. swim in the mountain river

Wednesday afternoon hike incl. swim in the mountain river

Another view from the hotel room

Another view from the hotel room

Apply for the Ascona workshop "Statistical and AI methods for multi-modal multi-scale modeling of biological systems", 28 Jun-3 Jul 2026 on Monte Veritร , Lago Maggiore at the foot of the Swiss Alps.

ascona2026.sciencesconf.org

15.01.2026 16:16 ๐Ÿ‘ 21 ๐Ÿ” 16 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 3
โ€œWhat a century, uh?โ€ โ€œCaptain, itโ€™s just one quarterโ€

โ€œWhat a century, uh?โ€ โ€œCaptain, itโ€™s just one quarterโ€

01.01.2026 09:08 ๐Ÿ‘ 1511 ๐Ÿ” 372 ๐Ÿ’ฌ 4 ๐Ÿ“Œ 4
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Comparison of Interventional Causal Structure Learning Algorithms for Gene Regulatory Network Inference Background: Causal structure learning offers a promising approach to studying gene regulation in cells, aiming to provide deeper mechanistic insights than purely association-based methods. Theoretical...

A new lab preprint is up: Work led by our MSc student Jan Sprengel comparing Interventional Causal Structure Learning Algorithms for Gene Regulatory Network Inference from single cell CRISPR perturbation screens ๐Ÿ‘‡ www.biorxiv.org/content/10.6...

10.12.2025 07:33 ๐Ÿ‘ 16 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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We have been working with Michal Klein on pushing a module to train *flow matching* models using JAX. This is shipped as part of our new release of the OTT-JAX toolbox (github.com/ott-jax/ott)

The tutorial to do so is here: ott-jax.readthedocs.io/tutorials/ne...

05.11.2025 14:04 ๐Ÿ‘ 13 ๐Ÿ” 7 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Look at the numbers! They are great! Good numbers, bold numbers, we have the best numbers!

Look at the numbers! They are great! Good numbers, bold numbers, we have the best numbers!

It's amazingly fast (< ๐Ÿ๐ก ๐Ÿ๐จ๐ซ ๐ญ๐ก๐ž ๐Ÿ๐ฎ๐ฅ๐ฅ ๐ฉ๐ข๐ฉ๐ž๐ฅ๐ข๐ง๐ž, ๐ญ๐ซ๐š๐ข๐ง๐ž๐ ๐จ๐ง ๐š ๐ ๐š๐ฆ๐ข๐ง๐  ๐ฅ๐š๐ฉ๐ญ๐จ๐ฉ) and high-quality.

Another Topological Deep Learning success story, coming soon to #NeurIPS2025!

๐Ÿ–ฅ๏ธ github.com/aidos-lab/in...
๐Ÿ“œ arxiv.org/pdf/2410.18987

4/n

29.10.2025 08:19 ๐Ÿ‘ 5 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Extremely honoured to receive the Bayer foundation early excellence in science award. Thanks to all my team, colleagues, collaborators and mentors for making this possible!

16.10.2025 15:18 ๐Ÿ‘ 17 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

My take: Engineering *is* important. Ideas are cheap. Novelty is overrated. "Hyperparameter tuning" is a cynically dismissive term for something that is in fact the real, difficult problem.

09.10.2025 14:13 ๐Ÿ‘ 31 ๐Ÿ” 7 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Nikolai Koehler goes over the materials of the first part of the course.

Nikolai Koehler goes over the materials of the first part of the course.

Panoramic view of the EMBO course classrom while Nikolai Koehler is talking.

Panoramic view of the EMBO course classrom while Nikolai Koehler is talking.

Wangjun Hu goes throught the materials of the second part of Practical session 5.

Wangjun Hu goes throught the materials of the second part of Practical session 5.

After the coffee break โ˜•, we continue with the second part of practical session 5, with Nikolai Kรถhler and Wangjun Hu ๐ŸŽ“ going through the different materials: from storing spatial-omics data ๐Ÿ’ฝ to learning spatial patterns using #MEFISTO ๐Ÿ˜Ž

17.09.2025 10:20 ๐Ÿ‘ 6 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Welcome to day 4 of #EMBOBioImage ๐Ÿ–ฅ๏ธ
๐Ÿ‘‰Happening right now: practical session 5, spatial statistics and omics integration, led by @brittavelten.bsky.social, assisted by Anna Klemm.

17.09.2025 10:15 ๐Ÿ‘ 8 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

I always find it funny that we obsess over sample size, yet peer review relies on the arbitrary opinions of just 2/3 people. That would be fine if editors were truly engaged, but given the workload, they donโ€™t have the time, or donโ€™t care enough. Anyway, Iโ€™m just glad it finally got published! ๐Ÿ‘

03.09.2025 15:09 ๐Ÿ‘ 4 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

@embl.org PhD programme just open - many interesting projects, including two with us @saezlab.bsky.social @ebi.embl.org - one on #host-microbiome interactions using #spatial omics, and one on #AI in #proteomics ๐Ÿ‘‡

02.09.2025 18:55 ๐Ÿ‘ 6 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation - Nature Metabolism The transcription factor ATF6 causes an enrichment in long-chain fatty acids in the colonic epithelium, which leads to changes in the gut microbiota and contributes to the development of colorectal ca...

Very happy to share our latest publication unravelling how the #ERstress sensor ATF6 stirs up trouble (and tumors) in #colorectalcancer. ATF6 drives CRC by reshaping lipid #metabolism and the intestinal #microbiota. A huge thank you to all co-authors! #lifesciences
www.nature.com/articles/s42...

02.09.2025 19:00 ๐Ÿ‘ 11 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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We spent a year writing this review of low-dim embeddings and arguing about things like epistemic roles and best practices :-) 20+ authors are all participants of the Dagstuhl seminar we held last year: www.dagstuhl.de/24122. Led by @alexandr.bsky.social and Cyril de Bodt.

arxiv.org/abs/2508.15929

27.08.2025 15:14 ๐Ÿ‘ 27 ๐Ÿ” 9 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
An overview of the Euler Characteristic Transform, illustrated for a single Euler Characteristic Curve, i.e., the calculation of Euler characteristics along a single direction.

An overview of the Euler Characteristic Transform, illustrated for a single Euler Characteristic Curve, i.e., the calculation of Euler characteristics along a single direction.

#MachineLearning loves data. #Topology loves shape.
Let's bring them together!

๐Ÿ‘‰The Euler Characteristic Transform (ECT) bridges both worlds, as I outline in a recent article in the Notices of the
@amermathsoc.bsky.social

Engage!

๐Ÿงต1/n

22.07.2025 08:16 ๐Ÿ‘ 10 ๐Ÿ” 5 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1
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Exciting kick-off meeting for our spatial omics seminar in and around Heidelberg organised with @tanevski.bsky.social and @denisschapiro.bsky.social. Was fun to see all the cool research happening here and connect. Reach out to us if you missed out and would like to join the next meetings!

03.07.2025 11:03 ๐Ÿ‘ 9 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Bioinformatics Software Engineer Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

๐Ÿš€ Job opportunity: Bioinformatics Software Engineer
Join a young and passionate team at Heidelberg University to advance bioinformatics software that drive biological discovery.
Learn more & apply ๐Ÿ‘‰ shorturl.at/GCpg7

25.06.2025 13:20 ๐Ÿ‘ 5 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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We're excited to be at the Kick Off Heidelberg Spatial-Omics Lunch Seminar Series with our very own @chiaraschiller.bsky.social presenting some of her PhD work!

01.07.2025 09:52 ๐Ÿ‘ 7 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐ŸŒŸWe're glad to announce that the brand new EMBL Conference #EMBLSpatialBiology is now open for registration โžก๏ธ https://s.embl.org/spb25-01-bl

Submit your abstract by 8 July and be part of the rapidly growing spatial biology community!

๐Ÿ—“๏ธ 14 โ€“ 17 October
๐Ÿ“ EMBL Heidelberg and Virtual

#ESSB2025

29.04.2025 09:00 ๐Ÿ‘ 5 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
Scientific programmer Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

JOB OPPORTUNITY: Join us as a scientific programmer to advance tools for multi-omics data at Heidelberg University. Details can be found at shorturl.at/OcnOa and please spread the word!

31.01.2025 08:12 ๐Ÿ‘ 7 ๐Ÿ” 11 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0