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Paul Jaschke

@pauljaschke

Senior Lecturer in Synthetic Biology, Macquarie University | Engineering phage & microbes to discover and create new biology.πŸ‡¨πŸ‡¦πŸ‡¦πŸ‡Ί πŸ‘¨β€πŸ‘©β€πŸ‘¦β€πŸ‘¦ 🦠🧬

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26.09.2023
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Latest posts by Paul Jaschke @pauljaschke

Genomic epidemiology of Ukraine conflict-associated Klebsiella pneumoniae reveals the emergence of a high-risk clone with a hybrid virulence-resistance plasmid vulnerable to lytic phages As antimicrobial resistance continues to rise and the development of new antimicrobials lags, we face an urgent threat where routine infections could become life-threatening. Armed conflicts, like the Russian war on Ukraine, intensify this crisis by accelerating the emergence and spread of resistant organisms across regions and borders. Phage Support Ukraine (Phage Sp UKR) is a collaborative effort to provide phages targeting circulating pathogens in Ukraine for delivery of personalized phage therapies. Within this context, we received multidrug-resistant bacterial isolates belonging to a number of different species. We here focus on Klebsiella pneumoniae , the most concerning pathogen with regard to prevalence, virulence and antibiotic resistance. Among the K. pneumoniae isolates, we identified sequence types (ST) 39, 101, 147, 307 and 395, as well as a predominating clonal groupβ€”CG10146 (ST23 KL57), first detected in Moscowβ€”carrying a hybrid virulence-resistance plasmid encoding NDM-1 and aerobactin. Over two years (2023–2025), this clonal group expanded and acquired pan-resistance. When tested in virulence assays, only one isolate (ST395) displayed hypervirulence in a Galleria mellonella though not in a mouse infection model. Several phages isolated from Ukrainian sewage were able to lyse these K. pneumoniae strains, including strains obtained from soldiers displaced in Belgium, Germany, and Latvia. Bacterial resistance was observed during in vitro testing. However, some phage-resistant isolates had mutations in virulence factors, including one that completely lost its hybrid plasmid, resulting in restored antibiotic susceptibility. Strategies like Phage Sp UKR are essential to prevent the selection, persistence, and global spread of these MDR clones. ### Competing Interest Statement The authors have declared no competing interest.

After 2 years of close collaboration with colleagues in #Kyiv, our work supporting a #phage therapy program in #Ukraine is now out as a preprint:

www.biorxiv.org/content/10.6...

22.01.2026 11:31 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
iVoMs – ISVM

The @isvm-society.bsky.social is organising monthly #virus of #microbes (including #phage). Nominate a speaker and register for the upcoming events at isvm.org/ivom/

17.02.2026 20:24 πŸ‘ 12 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
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My frangipani tree is finally flowering! It only took six or seven years

11.01.2026 11:27 πŸ‘ 6 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0
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This is actually quite brilliant, up to and including the final sentence πŸ”₯

01.12.2025 11:09 πŸ‘ 27605 πŸ” 10760 πŸ’¬ 546 πŸ“Œ 919

Real viruses do the same thing!

20.08.2025 10:36 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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RFK Jr. Mandates All Americans Drink Mysterious Glowing Liquid WASHINGTONβ€”Claiming the luminous potion would make the nation strong and vigorous, Health and Human Services Secretary Robert F. Kennedy Jr. issued an order Friday directing all Americans to drink a m...

RFK Jr. Mandates All Americans Drink Mysterious Glowing Liquid

12.08.2025 15:59 πŸ‘ 15744 πŸ” 2941 πŸ’¬ 648 πŸ“Œ 284
Australia Admits All Those Animals Made Up

Australia Admits All Those Animals Made Up

Australia Admits All Those Animals Made Up theonion.com/austral...

05.08.2025 22:00 πŸ‘ 5677 πŸ” 748 πŸ’¬ 132 πŸ“Œ 75
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Bitcoin buried in Newport landfill - Wikipedia

Anytime you think things aren't going well just remind yourself of Mr. Howells who mistakenly disposed of a laptop hard drive containing the private key for 8,000 Bitcoin en.wikipedia.org/wiki/Bitcoin... #downandout #bitcoin

04.08.2025 22:49 πŸ‘ 8 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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After a decade of death, Canadian scientists say they've found the sea star killer | CBC News A team featuring Canadian scientists has, after years of testing, determined the cause of the devastating sea star wasting disease. The culprit is a bacterial pathogen called vibrio pectenicida, and h...

I’ve been casually watching this story for years. Glad to see there has been recent progress and potential for their recovery! It is hard to express how big and amazing these stars are when you are diving. www.cbc.ca/news/science...

04.08.2025 22:57 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Congress eliminated public media funding, and the president signed it into law. At a time of deep division, public media brings us together.

Help keep it strong. Join our monthly donors today: n.pr/458sOhq

28.07.2025 15:50 πŸ‘ 12398 πŸ” 4226 πŸ’¬ 499 πŸ“Œ 156

Some journals are claiming that you need to pay big $$ for gold open access to comply with NIH's new public access policy. FYI that is total bs. You can comply by depositing the Accepted Manuscript into PubMed Central on the Date of Publication without embargo. Pass it on.

26.07.2025 00:52 πŸ‘ 121 πŸ” 63 πŸ’¬ 6 πŸ“Œ 5
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Amid Fear of Retaliation, N.S.F. Workers Sign Letter of Dissent In a public letter, employees of the National Science Foundation accused the administration of politicizing the agency and impeding scientific innovation.

"A Proposed Budget Cut That Would Cripple American Science." --Amid Fear of Retaliation, N.S.F. Workers Sign Letter of Dissent. Story by @alexaroblesgil.bsky.social Gift link: nyti.ms/3IFzGKJ

23.07.2025 13:48 πŸ‘ 354 πŸ” 98 πŸ’¬ 4 πŸ“Œ 2

The first known use of 'avocado toast' was in 1928.
The Great Depression was a year later.

Now, we're not saying that that's the reason, but...

22.07.2025 15:12 πŸ‘ 1055 πŸ” 166 πŸ’¬ 19 πŸ“Œ 16
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Between two trees: Vancouver man maps more than 2,600 places to hang a hammock He had the idea while hanging in a hammock.

When your city has an open data portal with the location of every tree, you can do this:

19.07.2025 03:59 πŸ‘ 94 πŸ” 18 πŸ’¬ 2 πŸ“Œ 5
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WGA statement on Paramount’s decision to cancel the Late Show with Stephen Colbert.

18.07.2025 18:03 πŸ‘ 19248 πŸ” 5779 πŸ’¬ 384 πŸ“Œ 395
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β€œDudes in Corollas”! Our friend Loren Miraglia, a scientist and brewer, often shares his latest creations with our lab. Today we sampled four versions of his Belgian-style quadrupel. The barrel-aged one was my favorite.

19.07.2025 02:16 πŸ‘ 22 πŸ” 2 πŸ’¬ 2 πŸ“Œ 1
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🚨 EU will pass 18th sanctions package against Russia today:
- Oil price cap 15% below market price
- Import ban on refined Russian oil products
- Nord Stream transactions ban
- 77 shadow fleet tankers
- 22 Russian banks cut from SWIFT
- 22 companies aiding Russia's military

18.07.2025 06:32 πŸ‘ 230 πŸ” 36 πŸ’¬ 8 πŸ“Œ 1
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So grateful for the clear, unequivocal witness and voice of Rep. @maxwellfrost.bsky.social who visited the horrifying detention camp in Florida. As he said, β€œI didn’t see any Russians who’ve overstayed their visas. Only Black & Latino men who look like me.” @maddow.msnbc.com

15.07.2025 01:59 πŸ‘ 18685 πŸ” 5504 πŸ’¬ 278 πŸ“Œ 134
Slide shows a picture of a petri dish and its close-up, showing methicillin-resistant Staphylococcus aureus; the pictures were published in our Microbial Genomics journal in 2015.

Slide shows a picture of a petri dish and its close-up, showing methicillin-resistant Staphylococcus aureus; the pictures were published in our Microbial Genomics journal in 2015.

Continuing celebrations of our 80th anniversary and looking back to our beginnings, here’s a close-up of methicillin-resistant Staphylococcus aureus (MRSA) from our first ever volume of Microbial Genomics - doi.org/10.1099/mgen... #MGen

07.07.2025 16:06 πŸ‘ 10 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
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Is it too late to give Sacha Baron Cohen an Oscar for this? Not a damn lie told. πŸ‡ΊπŸ‡Έ

22.06.2025 19:53 πŸ‘ 25637 πŸ” 10082 πŸ’¬ 622 πŸ“Œ 1332
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#booksky #writingcommunity

17.06.2025 14:51 πŸ‘ 12289 πŸ” 3006 πŸ’¬ 164 πŸ“Œ 106
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Mike Lee Stresses He Would Have Posted Same Thing If Own Family Savagely Murdered WASHINGTONβ€”After being confronted about social media posts that blamed the shootings of two Minnesota lawmakers on the far left, Sen. Mike Lee (R-UT) stressed Tuesday that he would have said the same ...

Mike Lee Stresses He Would Have Posted Same Thing If Own Family Savagely Murdered

17.06.2025 19:02 πŸ‘ 16719 πŸ” 3006 πŸ’¬ 506 πŸ“Œ 197
Photo from RFK JR.’s Twitter account of Kristi Noem, Rand Paul and RFK Jr standing in front of a sign that says NIAID IRF. The text of the tweet says With @Sec_Noem and @SenRandPaul inspecting the biological hazard labs at Fort Detrick.
NIAID.

Photo from RFK JR.’s Twitter account of Kristi Noem, Rand Paul and RFK Jr standing in front of a sign that says NIAID IRF. The text of the tweet says With @Sec_Noem and @SenRandPaul inspecting the biological hazard labs at Fort Detrick. NIAID.

I hope everyone at these labs is in full PPE to protect them from these three pathogens.

16.06.2025 22:44 πŸ‘ 553 πŸ” 70 πŸ’¬ 38 πŸ“Œ 41
A screen shot of an email reading: 

Dear Dr. Gill, Jacquelyn,
 
I am writing to let you know that given the current budgetary projections and recent adjustment of NSF’s over-arching priorities, NSF/BIO will not be making any new awards through the Biology Integration Institutes Program. Therefore, the solicitation has been archived, and NSF has returned your proposal without review so you can re-submit it, or portions of it, to appropriate BIO programs that currently are receiving new proposals, if you wish.
 
Sincerely,
 
Jim Deshler
Division Director (Acting)
Division of Biological Infrastructure

A screen shot of an email reading: Dear Dr. Gill, Jacquelyn, I am writing to let you know that given the current budgetary projections and recent adjustment of NSF’s over-arching priorities, NSF/BIO will not be making any new awards through the Biology Integration Institutes Program. Therefore, the solicitation has been archived, and NSF has returned your proposal without review so you can re-submit it, or portions of it, to appropriate BIO programs that currently are receiving new proposals, if you wish. Sincerely, Jim Deshler Division Director (Acting) Division of Biological Infrastructure

Last February, I led a proposal submission that encompassed six months, hundreds of hours, four institutions, a massive team, and and 256 pages. NSF just informed us that the entire Biology Integration Institute program was archived and our proposal would not even be reviewed.

With a form email.

16.06.2025 22:27 πŸ‘ 1262 πŸ” 457 πŸ’¬ 96 πŸ“Œ 28
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Before captivity β€” a proud, strong defender of Ukraine.
After captivity β€” tired, hungry, tortured... but not broken.

This is what Russian captivity looks like.
And what is most painful? The world pays almost no attention to it. πŸ‘‡

16.06.2025 11:50 πŸ‘ 165 πŸ” 59 πŸ’¬ 6 πŸ“Œ 8
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#NoKings

14.06.2025 17:35 πŸ‘ 29 πŸ” 6 πŸ’¬ 2 πŸ“Œ 0
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We are developing a killer team of phage biologists here who are ready to take on any challenge. My best moments each week are when these guys drop by to chat :) #NZLabLife @microsky

www.canterbury.ac.nz/news-and-eve...

12.06.2025 09:05 πŸ‘ 28 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Durbin to Bhattacharya: "I can't understand it. I disagree w/ this admin on so many things. But this is the one that really gets to me personally. To think this nation would walk away from medical research. For God's sake...cancer, your budget requests a 38% cut to the National Cancer Institute"

10.06.2025 15:02 πŸ‘ 16564 πŸ” 5564 πŸ’¬ 503 πŸ“Œ 247
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05.06.2025 22:49 πŸ‘ 103 πŸ” 13 πŸ’¬ 7 πŸ“Œ 2
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πŸ˜• pretty much

05.06.2025 12:24 πŸ‘ 8680 πŸ” 2690 πŸ’¬ 143 πŸ“Œ 107