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Elias Spiliotis

@septinlab

Professor of Cell Biology (University of Virginia), Research Scientist. Science, music, sports and politics. Opinions are my own and not of my lab or university.

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Latest posts by Elias Spiliotis @septinlab

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13.03.2026 22:26 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

This is likely solving the mystery of how septins are being identified as autoimmunity antigens. Exciting.

13.03.2026 18:38 ๐Ÿ‘ 1 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Motor activity of nonmuscle myosin 2A is a key component of bipolar filament turnover in cells

www.biorxiv.org/content/10.6...

12.03.2026 11:44 ๐Ÿ‘ 5 ๐Ÿ” 4 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

It will eventually happen once an alternative emerges in the ecosystem. Think the phonomenon is still fairly new. The publication landscape right now is very different than it was 25 years ago. And will be very different in 25 years from now.

12.03.2026 00:13 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Hot take: the Science/Nature/Cell brand is self cannibalizing through the obscenity of big volume firehose publishing of Sci Adv/Nat Comm/Cell Rep etc. At 10,000 pubs per year... there is no brand anymore. Just a glorified bioRxiv.
Just another paper lost in thousands of others.

11.03.2026 22:05 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0

Letโ€™s go!

08.03.2026 12:29 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

๐Ÿ”ฅ Gorillaz w/ new album and big tour this year

08.03.2026 10:31 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Any data out there on raw Impact score distribution after the change of review criteria (from five to three) in Jan '25?

Has this resulted in score inflation, deflation or no change?

There were 338 grants at 15th percentile in '25 vs 269 '24.

Could be due '25 bottleneck but maybe not entirely?

07.03.2026 22:16 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Post image

#Question: This may sound like I'm crazy but has anyone experienced immersion oil solidifying or getting stickier after light exposure? Until recently I noticed the oil suddenly gives off a lot of autofluorescence after ~10 mins of imaging, becomes thicker. Have to wipe constantly, really annoying.

07.03.2026 21:12 ๐Ÿ‘ 11 ๐Ÿ” 7 ๐Ÿ’ฌ 5 ๐Ÿ“Œ 2

Think it was Mahatma Gandhiโ€ฆ

06.03.2026 05:20 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
NIH Office of Extramural Research announcements of feedback sessions for NIH-wide strategic plan for March 16 and April 8.

NIH Office of Extramural Research announcements of feedback sessions for NIH-wide strategic plan for March 16 and April 8.

IMPORTANT---IMPORTANT---IMPORTANT

NIH is seeking input for the NIH-wide Strategic Plan. Open to everyone but Registration is Required!

Your chance to listen and get your 2 or more cents in.

grants.nih.gov/news-events/...

04.03.2026 19:49 ๐Ÿ‘ 35 ๐Ÿ” 45 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
Preview
Greece sends warships, fighter jets to defend Cyprus after drone strike The deployment comes after a Shahed-type unmanned aerial vehicle hit Britainโ€™s airbase at Akrotiri in Cyprus overnight.

Greece: hold my ouzo, malakes!

www.politico.eu/article/gree...

03.03.2026 00:30 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Sad news indeed. Pioneer of the genomics era as we know it (genetic linkages/microarrays), and in the cytoskeleton field (tubulin/actin) during the heyday of yeast genetics.

28.02.2026 23:34 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Post image

Well said, Philly.

28.02.2026 20:17 ๐Ÿ‘ 19 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

"Since Wilfrid Rallโ€™s seminal work was published in the 1960s, the field has increasingly appreciated that individual dendritic branches can act like neurons within a neuron"

Apical vs basal dendrite differentiation/polarity is so fascinating... and there is nearly zero cell biology about it.

28.02.2026 07:39 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

One more reason to Stand Up For Science next weekend:

www.standupforscience.net/march7

In DC or a city near you:

fight2win.standupforscience.net/Rallies-2026....

28.02.2026 07:15 ๐Ÿ‘ 13 ๐Ÿ” 7 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
Preview
a man in a suit and tie says just saying in front of a map ALT: a man in a suit and tie says just saying in front of a map

We need a bioRxiv for review articles...

26.02.2026 14:49 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Measles was wiped out in the U.S. 25 years ago and now weโ€™re already past 1,000 cases in February because vaccination rates dropped below the safety line. This is what happens when public health gets gutted and people stop trusting basic science.

25.02.2026 14:13 ๐Ÿ‘ 10424 ๐Ÿ” 3268 ๐Ÿ’ฌ 488 ๐Ÿ“Œ 179
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Leader of Columbia Brain Institute Quits Over Friendship With Epstein

Dang. Feels like the Jessell story was (7 yrs ago) yesterday.

The money addiction in science is real...

And seems the haves can never have or get enough of it.

#SpreadTheWealth

www.nytimes.com/2026/02/25/n...

25.02.2026 11:36 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Wish I had a lawsuit against FedEx everytime they have screwed up my labโ€™s deliveries - examples include a cracked anti vibration optical table, a $800 dollar shipment of protein from Europe (holiday rates apply), multiple orders of perishable brain tissueโ€ฆ and the list goes on and on.

24.02.2026 09:55 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Please share widely--there are rallies planned across the nation--look for one near you

23.02.2026 14:14 ๐Ÿ‘ 7 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Angine de Poitrine - Sherpa (Live on KEXP)
Angine de Poitrine - Sherpa (Live on KEXP) YouTube video by KEXP

Woah. Just woah! ๐Ÿคฏ

youtu.be/sfDtfz7vXkY

21.02.2026 20:28 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Linking molecular tension and cellular tractions: a multiscale approach to focal adhesion mechanics - Communications Biology Simultaneous mapping of tractions and molecular tension reveals how cells coordinate forces across scales, from whole-cell mechanics to polarized force transmission within individual focal adhesions.

Linking molecular tension and cellular tractions: a multiscale approach to focal adhesion mechanics
www.nature.com/articles/s42...

21.02.2026 08:54 ๐Ÿ‘ 7 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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a man is sitting at a desk with a canon camera behind him ALT: a man is sitting at a desk with a canon camera behind him

Looking forward to research supply prices and subcharges going down effectively today...

(yeah, the ones levied to offset tariffs)

Holding my breath

20.02.2026 18:38 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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a man wearing a mardi gras mask with beads around his neck ALT: a man wearing a mardi gras mask with beads around his neck

Looking for bead baths - formerly known as water baths.

Anyone has any recommendations for good ones?

19.02.2026 13:30 ๐Ÿ‘ 0 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

"Republics that work" for 500

19.02.2026 11:32 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Mark Rothko canvas, red on red

Mark Rothko canvas, red on red

Happy year of the fire horse

[Mark Rothko, Red on Red, 1969]

17.02.2026 12:40 ๐Ÿ‘ 568 ๐Ÿ” 129 ๐Ÿ’ฌ 7 ๐Ÿ“Œ 6

๐Ÿ˜ฎ๐Ÿคฏ

17.02.2026 09:56 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Molecular Biology of the Cell (MBoC)

Just in caseโ€ฆ we are looking for submissions for special issue on septins in MBoC:

www.molbiolcell.org/cell-biology...

15.02.2026 11:36 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Septin-coated microtubules promote maturation of multivesicular bodies by inhibiting their motility - PubMed The microtubule cytoskeleton consists of microtubule subsets with distinct compositions of microtubule-associated proteins, which instruct the position and traffic of subcellular organelles. In the endocytic pathway, these microtubule-associated cues are poorly understood. Here, we report that in MD โ€ฆ

Exciting. Nice to see it out. We had tried to go after the AP3 connection in early days of grad student project but did not get too far and went on a different direction:
pubmed.ncbi.nlm.nih.gov/38668767/

15.02.2026 03:41 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0