Jorge Iván Castillo-Quan

Congrats to AGE 2026 Early Career Scholar Awardee Jorge Ivan Castillo-Quan (Joslin Diabetes Center, Harvard Medical School)!

👏 Well deserved!
#Geroscience #AgingResearch #Longevity #Proteostasis

New preprint! Very excited for this collaboration with Dr. Moroz to be out. Shout out to the nine Emmanuel College undergrad students, especially Aiden McCarty. We dedicate this work to the memory of our beloved T. Keith Blackwell. biorxiv.org/content/10.110…

Kruppel-like factor 1 acts upstream of the SKN-1/Nrf transcription factors to modulate oxidative stress, lipid homeostasis and longevity https://www.biorxiv.org/content/10.1101/2025.11.22.689963v1

I’m excited to share this paper from Dr. Kimitaka Shibue in Dr. Rohit Kulkarni’s lab at the Joslin Diabetes Center @harvardmed.bsky.social, where they found that secretory machinery proteins modulate the ER unfolded protein response. Read more about it here for free: www.nature.com/articles/s41....

Excited to share our collaborative PhD project with Adam Dobson (Adam.Dobson@glasgow.ac.uk) on interorgan signalling in the ageing gut. Please contact Adam If you are a highly motivated student wanted to work on a super exciting Fly project.

Early in May, and too early in his life, my dear mentor Prof. Keith Blackwell passed unexpectedly. Please join us in celebrating Keith’s scientific achievements & legacy with my colleagues at the Joslin & Prof. Gary Ruvkun, a close & long-lasting colleague. #scientificlegacy #skn1 #aging #metabolism

Large language model-based biological age prediction in large-scale populations | Nature Medicine Accurate and convenient assessment of individual aging is crucial for identifying health risks and preventing aging-related diseases. Nonetheless, current aging proxies often face challenges such as methodological limitations, weak associations with adverse outcomes and limited generalizability. Here we propose a framework that leverages large language models (LLMs) to estimate individual overall and organ-specific aging using only health examination reports. We validated this approach across six population-based cohorts, encompassing over 10 million participants and demonstrated effectiveness and reliability. Our results showed that the LLM-predicted overall age achieved a concordance index (C-index) of 0.757 (95% CI 0.752–0.761) for all-cause mortality, significantly outperforming other aging proxies such as telomere length, frailty index, eight epigenetic ages and four machine-learning models predictions. The overall age gap was strongly associated with multiple aging-related phenot

LLM predicts biological age from health reports, enhancing aging analysis in populations. Validated in six datasets: stronger outcomes! PMID:40702324, Nat Med 2025, @NatureMedicine https://doi.org/10.1038/s41591-025-03856-8 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Calling all @apsphysiology.bsky.social members: let’s help raise some money to support ABRCMS student presentation awards! Goal is $1200/discipline to support 12 awards by Sept 30th! 🧪 abrcms.org/donate/stude...

Scientists no Longer Find Twitter Professionally Useful, and have Switched to Bluesky Synopsis. Social media has become widely used by the scientific community for a variety of professional uses, including networking and public outreach. For

Hey everybody! @drjuliawester.bsky.social and I have a new paper!

We surveyed over 800 scientists, science communicators, and science educators who use social media.

Conclusion: Scientists no longer find Twitter useful or pleasant, and many have switched to Bluesky! 🧪🌎🦑

doi.org/10.1093/icb/...

Why would anyone want to be a scientist? It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...

A little gem here from Martin Schwartz, PhD the Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Biomedical Engineering and of Cell Biology at Yale University

Felt good to read and share and I predict you just might have the same experience

A first-rate review of MASH (fatty liver disease) @nejm.org www.nejm.org/doi/full/10....

Countrywide natural experiment links built environment to physical activity - Nature By analysing the smartphone data of 2,112,288 participants, in particular observing and comparing the activity of the same individual in two different environments, we find that increases in the walka...

A natural experiment provides evidence for promoting moderate-vigorous physical activity: the importance of walkable cities
www.nature.com/articles/s41...

Dementia Researcher Salon - Should I stay or should I go... does research need me? Dementia Researcher Salon - Should I stay or should I go... does research need me?

Ever thought about leaving academia? You’re not alone. Tomorrow at 12pm we talk openly about doubt, purpose, and finding your place in dementia research.

communities.dementiaresearcher.nihr.ac.uk/c/events/sho...

Why does Zepbound (tirzepatide) lead to more weight loss than Ozempic (semaglutide)?
The dual receptor (GLP-1+ GIP) has more pronounced effects in the brain
www.cell.com/cell-metabol...

One of our most read articles is Martin's essay on the importance of stupidity in scientific research: journals.biologists.com/jcs/article/...

We are looking for a Director to lead the Cancer Research UK Cambridge Centre! The Centre unites over 1,200 members and 200 research groups in Cambridge.

Find out more about the role ➡️ zurl.co/4W2gC 
 
@cam.ac.uk @cancerresearchuk.org @cambridge-scm.bsky.social @cambcancer.bsky.social

How are ribosomes assembled? Sign up now and get the chance to explore new strategies targeting #ribosome synthesis at the EMBO Workshop "Ribosome synthesis: From mechanisms to therapy" in Cambridge, UK, 7–12 September

Deadline: 22 August

www.eventsforce.net/hg3/317/home
#EMBOevents 🧪

Please RT 🙏 If you’re an early career researcher working in the fields of structural or synthetic biology wishing to start your lab then come join us at Imperial. We’re looking to support outstanding individuals for external Career Development Awards/Fellowships.

www.imperial.ac.uk/media/imperi...

Besides compelling new evidence for the potential benefit of lithium protection vs Alzheimer's in multiple animals models, another discovery was that lithium orotate at doses much less than 1/1000th of lithium carbonate could be effective, and why, in people
erictopol.substack.com/p/lithium-an...

Assoc / Professor: Cognitive Neuroscience UCL, London seeks an internationally recognised leader in imaging informed cognitive neuroscience to shape research, lead teams and advance brain understanding.

University College London seeks an internationally recognised leader in imaging informed cognitive neuroscience to shape research, lead teams and advance brain understanding. Closing date: 9th September

www.dementiaresearcher.nihr.ac.uk/job/assoc-pr...

Our combined commitment to actively involve older people in research - Vivensa Foundation The Chief Medical Officer for England’s 2023 Annual Report on Health in an Ageing Society identified that more research needs to include older people. As a result of this, the Vivensa Foundation has j...

The Chief Medical Officer for England’s 2023 Annual Report on Health in an Ageing Society identified that more research needs to include older people. That's why we've joined a number of organisations to sign a statement of intent and to take action.

Read more here: tinyurl.com/e7cnvayt

"Solo puedo notar que el pasado es hermoso porque uno nunca se da cuenta de una emoción en el momento. Se expande más tarde, y por lo tanto no tenemos emociones completas sobre el presente, solo sobre el pasado". Virginia Woolf

The stunning color composite image features RCW 120 region, a nebula about 10 light-years across.You may admire an expanding bubble of ionized gas appearing as a reddish glow at the center, surrounded by blue clouds. The visual composition, enhanced by a black background filled densely with bright spots, creates a contrast between the bright red of the ionized gas and the cooler blue clouds, giving a sense of depth and dynamism.

🧵
This nice color composite from APEX shows RCW 120, an emission nebula and H II region located some 4,300 ly away in Scorpius.

RCW 120's dominant feature is a large, regularly shaped stellar-wind bubble, visible at submillimeter wavelengths.

➡️ www.eso.org/public/unite...

🔭 🧪 #science #galactic

Hace tanto calor que acabo de ver un pájaro soplándole al gusano antes de comérselo.

Redox Dyshomeostasis Links Renal and Neuronal Dysfunction in Drosophila Models of Gaucher and Parkinson's Disease Gaucher disease (GD), the most common lysosomal storage disorder, is caused by bi-allelic mutations in the GBA1 gene. Variants in GBA1 also represent the most frequent genetic risk factor for Parkinso...

New from the Kinghorn Lab! 🧠🔬 Our latest preprint shows that in fly 🪰🧬 Gaucher’s & Parkinson’s 🧠 models, kidney dysfunction drives neurodegeneration - supporting emerging links between renal health & Parkinson's. You can read it here:
www.biorxiv.org/content/10.1...

lithium ion trapped by beta-amyloid and the way to get around it

Could a metal ion supplement that cost pennies per day protect from Alzheimer's disease?
erictopol.substack.com/p/lithium-an...

This is figure 5, which shows the therapeutic efficacy of a plaque-evading lithium salt.

Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level, according to a paper in Nature. go.nature.com/47mxemu #medsky 🧪

The brain is the master regulator of food intake and energy balance. A brilliant new @cellpress.bsky.social review, including the mechanism of GLP-1 drugs, by @clemmensenc.bsky.social and colleagues, open-access
www.cell.com/cell/fulltex...

Professor: Alzheimer’s Genetics & Genomics / Neuropathology & Neurodegeneration The Penn Neurodegeneration Genomics Center seeks an Associate or Full Prof to lead Alzheimer’s genomics research and teaching within its multidisciplinary team.

The Penn Neurodegeneration Genomics Center seeks an Associate or Full Professor to lead Alzheimer’s genomics research and teaching within its world leading multidisciplinary team. Closing date: 5th October

www.dementiaresearcher.nihr.ac.uk/job/professo...

RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature N-glycans on glycoRNAs prevent innate immune sensing of endogenous small RNAs, and the natural mechanism they use demonstrates how glycoRNAs exist on the cell surface and in the endosomal network with...

Hi everybody! I am super excited to share the work done during my PhD published in @nature today! We describe a new mechanism of self- vs. non-self RNA discrimination by showing how N-glycans shield glycoRNAs from stimulating endosomal RNA sensors www.nature.com/articles/s41...