Melvin Chan

a man is smiling and saying it 's madness ALT: a man is smiling and saying it 's madness

It is officially March 1, and you know what that means!! #NephMadness! @nephmadness.bsky.social

Learn more here: ajkdblog.org/2026/03/01/w...

a picture of a puppy with the caption who 's awesome ALT: a picture of a puppy with the caption who 's awesome

Excellent job #NephJC interns!!

I have only used this medication in a few patients. But it is interesting that it caused hypotension in one of my patients that I had to stop her ACE. When I looked at Lexicomp for PNH, it said hypertension. But a few of the experts had seen this AE before. #NephJC

I asked Dr Dixon (my mentor) about sequential complement blockade before and he said he would be really concern about the infectious risk but def a future study to look at #NephJC

Biomarkers in the Management of Complement-Mediated Kidney Diseases in the Era of Complement Therapeutics - PubMed Pharmacologic complement inhibition offers a promising therapeutic strategy for several complement-mediated kidney diseases. Yet, at present, nephrologists must rely on an incomplete toolkit of histopathologic and circulating biomarkers to assess complement activity in complement-mediated kidney dis …

Agree! We have so many complement therapies now but not enough markers for continued monitoring. A selfish plug but our working group did a review on those biomarkers #NephJC: pubmed.ncbi.nlm.nih.gov/41404698/

a little girl wearing a leopard print shirt is making a face ALT: a little girl wearing a leopard print shirt is making a face

Love this trial, included pediatric data! @rheaultm.bsky.social is smiling now. #NephJC

Yeah I am actually surprised at how receptive people have been when I prescribe it to my Peds patients. Granted I give them Emla cream to use. I have people prefer subQ over oral Wegovy on the adult side. #NephJC

I remember learning about MPGN in my First Aid book and it made no sense. Glad they changed it! How many of yall have seen C4GN? Just learning about it now #NephJC

Late to the game but a pediatric nephrologist here in CO. No COI #NephJC

Can’t wait for this discussion. Already have a few patients on it and have been going well! #NephJC

New phase 3 data from the ATTAIN-MAINTAIN trial. #NephSky #Obesity #GLP1

lilly.mediaroom.com/2025-12-18-L...

The future of nephrology

Appreciate this excellent work showing GLP-1 agonists reduce mortality in patients on dialysis and improve their chances of receiving a transplant. Hopefully, it will help me get them approved for my patients through the VA. #nephsky journals.lww.com/cjasn/pages/...

Congenital and infantile nephrotic syndrome: genotype-phenotype associations pubmed.ncbi.nlm.nih.gov/41339767/

Thrilled to have our review article on complement-mediated biomarkers published #NephSky

journals.lww.com/cjasn/abstra...

Excited to match two amazing nephrology fellows for next year! @childrenscolo.bsky.social

Glucagon-Like Peptide-1 Receptor Agonist Use and the Risk of Adverse Cardiac and Kidney Outcomes Among Patients with Systemic Lupus Erythematosus and Lupus Nephritis - PubMed We found lower risks of adverse CV and kidney outcomes and mortality with GLP-1RA use compared with DPP4i use among patients with lupus and T2D.

More evidence showing that GLP1s may be modulate rheumatic disease #MedSky #NephSky:
rheumatology.org/press-releas...

and

pubmed.ncbi.nlm.nih.gov/40994310/

More tools for our advanced CKD patients!

Late breakers that included children:
✅Setanaxib in Alport (12+)

Late breakers that did NOT include children:
🚫Atacicept in IgAN
🚫CONFIDENCE
🚫PISCES: Fish oil in Dialysis
🚫LIBERATE-D
🚫balcinrenone + dapa
🚫Obintuzumab in lupus nephritis
🚫Sibeprenlimab in IgA
🚫MIL62 in membranous
+more
#KidneyWk

How many people see HSP as a spectrum of IgAN? Feel like most in the pediatric world see HSP more acutely and if persists past a year treat it like IgAN #NephJC

The one other caveat about children is they tend to have more acute lesions like crescents. That is one major difference reasons why in pediatrics we are more aggressive with immunosuppression #NephJC

🎨Beautiful visual abstract by Dr Natalia Nombera @roxnonna23.bsky.social #NephJC

www.nephjc.com/news/...

Late at joining, Melvin here in CO, no COI #NephJC

Towards new ways of assessing kidney function. Where to look to improve? Written by Elba MedinaReviewed by Brian Rifkin;Sophia AmbrusoToday, current methods for measuring kidney function, due to several critical limitations, need to be reimagined. In the reimagining Kidney...

Great read on ways of measuring renal function. Shout out to @elbaonelida.bsky.social

www.kireportscommunity.org/post/towards...

Bleeding, Clotting, and Kidney Disease in Atrial Fibrillation: Can Factor XI Inhibitors Change the Game? Explore how we are uncoupling hemostasis and thrombosis via Factor XI inhibitors and how it is may change anticoagulation for atrial fibrillation in kidney disease

A great read on the history and upcoming anticoagulation targets especially for our dialysis patients! #NephSky

www.kireportscommunity.org/post/bleedin...

First Randomized Trial of Tirzepatide in T1D Shows Benefits Tirzepatide reduced weight, A1c, and insulin dose in type 1 diabetes in a small randomized controlled trial.

Looks like tirzepatide have benefits for those with T1DM, with insulin needs reduced within 2 weeks of treatment. #NephSky #MedSky

www.medscape.com/viewarticle/...

So exciting! Also it’s a non peptide form so you don’t have to fast!

Yup! Especially if it synchronizes with telmisartan. Only barrier is the cost of it. But hopeful it will come down, especially with oral formulations coming out in 1-2 years! Orfoglipron showing 13% weight loss and no need to fast! #NephJC

two cartoon characters giving each other a high five in front of a blue background that says high five ALT: two cartoon characters giving each other a high five in front of a blue background that says high five

Wonderful job team!! #NephJC

That’s really interesting. I wonder why? Feel like most PCP I see still use lisinopril the most and then use ARB #NephJC