LOV-BirA, light regulated biotin ligase, engineered by Song-Yi Lee

www.sciencedirect.com/science/arti...

Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling Combining bioorthogonal protecting groups with localized catalysts that can unmask them is a powerful approach to spatially and temporally modulate molecular activity. Enzymes are appealing catalysts ...

Excited to share a new pre-print on a joint study between my group and @chembiobryan.bsky.social‬! Directed Evolution of Enzymes for Bioorthogonal Chemistry Using Acid Chloride Proximity Labeling. chemrxiv.org/engage/chemr...
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dream team much?!

Site-selective protein editing by backbone extension acyl rearrangements - Nature Chemical Biology A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-peptide, γ-peptide or δ-pe...

A post-translational backbone extension acyl rearrangement (BEAR) reaction has now been developed that converts a ribosomal protein product into a new product containing a β-, γ-, or δ-peptide backbone

www.nature.com/articles/s41...

Congrats, science brother!

Picture of a smiling person holding up a copy of a book.

First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that.

This book is the guide I wish I’d had then, with the goal of helping others now.
 
jenheemstra.com/book

Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?

www.biorxiv.org/content/10.1...

I don't disagree and I have data (now rather old but I bet still relevant) to support this.

loop.nigms.nih.gov/2011/06/prod...

Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III - Nature An approach that combines single-nucleus RNA sequencing and multiplexed perturbation identifies genes that enable the biosynthesis of direct precursors of the anti-cancer drug Taxol, whose curren...

Exciting new work from Sattely lab with collaborator @pollyfordyce.bsky.social and coworkers @stanford-chemh.bsky.social, solving they biosynthesis of taxol!

www.nature.com/articles/s41...

Awesome to hear so much great science today at the New York Academy Chemical Biology Year-End Symposium, and proud of grad student Jessie Mohsen, who gave an awesome talk on an overlapping, stress-response microprotein in E. coli. Thanks to @davidlabmsk.bsky.social and the rest of the organizers!

Opinion | Science Suffers With Trump’s Funding Freeze America’s scientific enterprise demands reliable stewardship, not destabilizing political intervention.

My father-in-law, Jack Strominger, and I wrote a letter to the @wsj.com editor about the current threats to science due to Trump's funding freeze. Please repost! www.wsj.com/opinion/scie...

New preprint drop! Check out work from @jimmy-ly.bsky.social et al for how protein isoforms generated by alternate translation initiation create dual localization, contribute to mitochondrial function, and are mutated in disease. "Blue-tutorial" thread below.

www.biorxiv.org/content/10.1...

Dr. Jeremy Baskin wins the 2024 ACS Chemical Biology Young Investigator Award | ACS Publications Chemistry Blog Get to know more about Dr. Baskin's work and career in this exclusive interview.

It’s an honor to receive the ACS Chem Biol Young Investigator Award! I’m most grateful for the contributions from all past & present lab members — it is an award for all of you as much as for me. (& also grateful to still be considered young 😅) axial.acs.org/chemical-bio...
@acsbiol.bsky.social 1/2

Transfer RNA acetylation regulates in vivo mammalian stress signaling An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.

Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.

www.science.org/doi/10.1126/...

Congrats to Anna Seminara on her paper out today in @cp-cellchembiol.bsky.social reporting a new approach to metabolite depletion using a bacterial ABC transporter, applied to study the antioxidant ergothioneine in H. pylori!

Detection of human unannotated microproteins by mass spectrometry-based proteomics: a community assessment Thousands of short open reading frames (sORFs) are translated outside of annotated coding sequences. Recent studies have pioneered searching for sORF-encoded microproteins in mass spectrometry (MS)-ba...

#Microproteins may be the next frontier in #proteomics. But figuring out the publications can be tough.

If you are looking for some advice about microprotein evidence, check out the latest from our consortium. Lead by @carvunis.bsky.social and Aaron Wacholder!

🧬 💻
#genomics
#RNASky

bit.ly/4bgJSDm

Graduate admissions being put on hold because of the chaos...

the word irony is written on a white background ALT: the word irony is written on a white background

I have been trying to find the time to move away from the polical hellscape we find ourselves in to finish and share a bluetorial about science.

This helps me remember what this is all about.

Ironically, it is about the treatment of pain.

Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article) Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

New York Times article now up on Federal Register stuff.

www.nytimes.com/2025/02/21/s...

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The hidden bacterial microproteome This study uncovers thousands of microprotein families encoded by intergenic small open reading frames (smORFs) in bacterial genomes and provides a publicly available resource featuring structural pre...

Excited to share our publication on bacterial microproteome www.cell.com/molecular-ce...
#microproteins

🚨 Chemical Biology & Probes study section (formerly SBCB, one of two NIH panels that reviews chemistry #chemsky 🧪) was abruptly POSTPONED w/no specific plans for rescheduling, less than 24h before start.

If this affects you call your reps & senators, talk to local news, make your voice heard 📢 👩‍🔬

March 7. Stand Up For Science. Rallies in DC and nationwide. 🧪

Please visit the website and spread the word.

www.standupforscience2025.org

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

One More Time: Why Diversity Leads To Better Team Performance Discussions on diversity in the workplace can be heated and contentious. But the data still shows more diverse teams outperform their less diverse peers. Here's how.

www.forbes.com/sites/roncar...

ONLY 200 days until the GRC on #microproteins launches!

Sign up now for the landmark event in the scientific field.

Don't miss this chance to meet all of the leaders in #RiboSeq, #RNA, #Proteomics, #Translation!

#genomics
#bioinformatics
🧬 💻
🔎 microproteins
#RNAsky

www.grc.org/decoding-mic...

Thinking of you & everyone at NIH!

PPI Prediction Challenge #2 For this protein-protein interaction prediction challenge, we present three target proteins: KRAS, RAF (the KRAS binding domain), and Mdm2. For each target protein, we are providing you a list of 8 po...

Back by popular demand, I present PPI Prediction Challenge #2.

My claim: I AM SKEPTICAL COMPUTATIONAL APPROACHES CAN PREDICT WHETHER TWO PROTEINS INTERACT.

Someone prove me wrong (take two).
docs.google.com/forms/d/e/1F...

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