Nezha Benabdallah's Avatar

Nezha Benabdallah

@nsbenab

Group leader at the University of Edinburgh. Chromatin, Gene Regulation & Sarcoma https://www.benabdallah-lab.com/

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21.12.2023
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Latest posts by Nezha Benabdallah @nsbenab

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We are offering 5 Postdoc Positions within the Max Planck Postdoc Program!

Take advantage and apply by April 13, 2026 to the positions in the labs of @ralfhadams.bsky.social, @ruibenedito.bsky.social and @katemiro.bsky.social.

Link to our website:
www.mpi-muenster.mpg.de/max-planck-p...

04.03.2026 11:04 πŸ‘ 4 πŸ” 5 πŸ’¬ 1 πŸ“Œ 0
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*Recruiting new group leaders*

The @lmcb-ucl.bsky.social at University College London are looking for outstanding candidates to sponsor for career development fellowships. Fellows would then be assessed for tenured positions at the end of the fellowship term.

02.03.2026 16:41 πŸ‘ 11 πŸ” 14 πŸ’¬ 2 πŸ“Œ 0
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1/3 New bioRxiv preprint from the lab: β€œMinute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

11.02.2026 04:06 πŸ‘ 37 πŸ” 17 πŸ’¬ 1 πŸ“Œ 1
Brain with puzzle overlay to show that our study provides missing pieces of the puzzle of human brain development by delivering the most comprehensive picture of hindbrain development to date. We have strived to go beyond just another multi-omics atlas to gain deep insights by:
1. Meticulously annotating cell clusters
2. Extracting regulatory programs in terms of coordinated gene sets and accessible regulatory elements
3. Using deep learning to identify regulatory syntax
4. Resolving context-specific TF activity

Brain with puzzle overlay to show that our study provides missing pieces of the puzzle of human brain development by delivering the most comprehensive picture of hindbrain development to date. We have strived to go beyond just another multi-omics atlas to gain deep insights by: 1. Meticulously annotating cell clusters 2. Extracting regulatory programs in terms of coordinated gene sets and accessible regulatory elements 3. Using deep learning to identify regulatory syntax 4. Resolving context-specific TF activity

Excited to share our preprint on our new multi-omic atlas of human hindbrain development. Led by postdoc Piyush Joshi, in collaboration with @kaessmannlab.bsky.social and Pfister labs, our atlas represents the first comprehensive view of human hindbrain development. www.biorxiv.org/content/10.6...

10.02.2026 07:04 πŸ‘ 32 πŸ” 15 πŸ’¬ 2 πŸ“Œ 0
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Opinion | I’m the Prime Minister of Spain. This Is Why the West Needs Migrants.

'The regularization effort underway in Spain actually began as a citizen-led initiative endorsed by more than 900 nongovernmental organizations, including the Catholic Church, and it has the support of business associations and trade unions alike.'

www.nytimes.com/2026/02/04/o...

06.02.2026 15:07 πŸ‘ 6 πŸ” 6 πŸ’¬ 0 πŸ“Œ 0
EZS European Zebrafish Society The European Zebrafish Society was formed as a successor of "EuFishBioMed e.V." to foster zebrafish research, providing a platform for researchers and a framewokr for grant funding for young researche...

Congratulations to @ezsociety.bsky.social Christiane NΓΌsslein-Volhard Award winner Liz Patton for her pioneering work with zebrafish models in melanoma research, outstanding scientific excellence, unwavering dedication to community service & shaping of learned societies πŸ‘‰https://edin.ac/4r1an7d

05.02.2026 12:52 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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RESEARCH PAPER: SOX2 phosphorylation during mitosis limits genomic damage
By Williams et al., and Steven Pollard
➑️ https://genesdev.cshlp.org/content/40/3-4/185.full

Edinburgh University
#sox2 #chromatin #neural #mitosis #stemcells #phosphorylation

04.02.2026 19:00 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0

This is for you – and a great opportunity – if you are establishing a group in Croatia, Czechia, Estonia, Hungary, Lithuania, Luxembourg, Poland, Portugal and TΓΌrkiye...

04.02.2026 08:42 πŸ‘ 6 πŸ” 8 πŸ’¬ 0 πŸ“Œ 0
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DOT1L provides transcriptional memory through PRC1.1 antagonism - Nature Cell Biology Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibit...

www.nature.com/articles/s41...

happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis

03.02.2026 21:29 πŸ‘ 22 πŸ” 7 πŸ’¬ 1 πŸ“Œ 0
Ad for a postdoc position in centromere biology with colorful chromosomes and centromeres made out of FIMO.

Ad for a postdoc position in centromere biology with colorful chromosomes and centromeres made out of FIMO.

πŸ§ͺ My lab has an opening for a postdoc position soon! Please share/get in touch!

03.02.2026 13:59 πŸ‘ 14 πŸ” 18 πŸ’¬ 0 πŸ“Œ 0
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Today in @natgenet.nature.com, we report a saturation genome editing study that systematically dissects the degron of Ξ²-Catenin, which contains 5 of the 25 most frequently mutated regions of the human cancer genome, and >70 recurrent missense mutations.

rdcu.be/e1Tvk

02.02.2026 16:10 πŸ‘ 16 πŸ” 5 πŸ’¬ 3 πŸ“Œ 0

Congratulations Pradeep!

02.02.2026 20:07 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...

02.02.2026 07:19 πŸ‘ 35 πŸ” 14 πŸ’¬ 7 πŸ“Œ 1
An example of a voter suppression ad on Facebook. This ad was part of a Russian election interference campaign.

An example of a voter suppression ad on Facebook. This ad was part of a Russian election interference campaign.

Exposure to voter suppression ads on Facebookβ€”which targeted non-White residents of battleground statesβ€”was associated with a 1.9% decrease in voter turnout in the 2016 election, representing approximately 4.7 million fewer votes nationwide. In PNAS: https://ow.ly/HJGf50Y7FPG

02.02.2026 20:01 πŸ‘ 10 πŸ” 7 πŸ’¬ 0 πŸ“Œ 1
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πŸ“£ I'm excited to share our latest preprint!

We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫

Read about Array-CNCC here:
www.biorxiv.org/content/10.6...

@uoe-igc.bsky.social

28.01.2026 14:36 πŸ‘ 48 πŸ” 13 πŸ’¬ 2 πŸ“Œ 1
SS18-SSX co-opts P300 to sustain oncogenic transcription independent of SWI/SNF activity Synovial sarcoma is driven by the SS18-SSX fusion oncoprotein, which has been assumed to promote tumorigenesis through its incorporation into the SWI/SNF chromatin remodeling complexes. Accordingly, therapeutic efforts have focused on targeting SS18-SSX containing SWI/SNF assemblies, yet these approaches have produced limited clinical benefit. Here, we demonstrate that SS18-SSX sustains oncogenic transcription independent of SWI/SNF activity. Despite efficient degradation and dismantling of SWI/SNF complexes, fusion occupancy at target loci and associated gene expression programs remain largely intact. Instead, we identify the acetyltransferase P300 as an essential co-factor supporting SS18-SSX chromatin binding and transcriptional activation. Targeting P300 displaces the fusion from chromatin, suppresses its transcriptional output, compromising synovial sarcoma viability. Notably, dual PROTAC mediated degradation of P300 and SWI/SNF produces strong synergistic effects, broadly disrupting SS18-SSX localization and function. These findings redefine the mechanistic basis of synovial sarcoma and reveal a mechanistically anchored therapeutic strategy for targeting its core oncogenic driver. ### Competing Interest Statement C.R.V. has been a consultant for Flare Therapeutics, Roivant Sciences and C4 Therapeutics; has served on the advisory boards of KSQ Therapeutics, Syros Pharmaceuticals and Treeline Biosciences; has received research funding from Boehringer Ingelheim and Treeline Biosciences; and owns stock in Treeline Biosciences. S.A.A. has been a consultant and/or shareholder for Neomorph, Imago Biosciences, Hyku Therapeutics, C4 Therapeutics, Accent Therapeutics and Nimbus Therapeutics; and has received research support from Janssen and Syndax. N.O.C. is a co-founder, shareholder and management consultant for PhenoTherapeutics Ltd; and a shareholder in Amplia Therapeutics Ltd All other authors declare no financial interests UKRI, EP/X039633/1 Worldwide Cancer Research, https://ror.org/031tfbz57, 21-0271 Science Foundation Ireland, https://ror.org/0271asj38, 18/SIRG/5573

Synovial sarcoma is driven almost exclusively by a single oncofusion – SS18-SSX

For years, the assumptions on disease mechanisms were simple:

➑️ SS18-SSX works by hijacking SWI/SNF chromatin remodeling activity

Our new study shows that assumption was wrong πŸ§΅πŸ‘‡

www.biorxiv.org/content/10.6...

28.01.2026 09:54 πŸ‘ 30 πŸ” 12 πŸ’¬ 2 πŸ“Œ 3

I did not know she was on Bluesky, but this whole work was led by @afroditisotiriou.bsky.social, a truly talented scientist that will finish her PhD this year and has not started looking for postdoc positions yet...

28.01.2026 10:36 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
SS18-SSX co-opts P300 to sustain oncogenic transcription independent of SWI/SNF activity Synovial sarcoma is driven by the SS18-SSX fusion oncoprotein, which has been assumed to promote tumorigenesis through its incorporation into the SWI/SNF chromatin remodeling complexes. Accordingly, therapeutic efforts have focused on targeting SS18-SSX containing SWI/SNF assemblies, yet these approaches have produced limited clinical benefit. Here, we demonstrate that SS18-SSX sustains oncogenic transcription independent of SWI/SNF activity. Despite efficient degradation and dismantling of SWI/SNF complexes, fusion occupancy at target loci and associated gene expression programs remain largely intact. Instead, we identify the acetyltransferase P300 as an essential co-factor supporting SS18-SSX chromatin binding and transcriptional activation. Targeting P300 displaces the fusion from chromatin, suppresses its transcriptional output, compromising synovial sarcoma viability. Notably, dual PROTAC mediated degradation of P300 and SWI/SNF produces strong synergistic effects, broadly disrupting SS18-SSX localization and function. These findings redefine the mechanistic basis of synovial sarcoma and reveal a mechanistically anchored therapeutic strategy for targeting its core oncogenic driver. ### Competing Interest Statement C.R.V. has been a consultant for Flare Therapeutics, Roivant Sciences and C4 Therapeutics; has served on the advisory boards of KSQ Therapeutics, Syros Pharmaceuticals and Treeline Biosciences; has received research funding from Boehringer Ingelheim and Treeline Biosciences; and owns stock in Treeline Biosciences. S.A.A. has been a consultant and/or shareholder for Neomorph, Imago Biosciences, Hyku Therapeutics, C4 Therapeutics, Accent Therapeutics and Nimbus Therapeutics; and has received research support from Janssen and Syndax. N.O.C. is a co-founder, shareholder and management consultant for PhenoTherapeutics Ltd; and a shareholder in Amplia Therapeutics Ltd All other authors declare no financial interests UKRI, EP/X039633/1 Worldwide Cancer Research, https://ror.org/031tfbz57, 21-0271 Science Foundation Ireland, https://ror.org/0271asj38, 18/SIRG/5573

Also very cool co-ordinated back-to-back with a sister preprint from colleagues (and office mate) @gerrybrien.bsky.social reporting the same finding 🀝
www.biorxiv.org/content/10.6...

28.01.2026 10:21 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

SS18::SSX activates Polycomb target genes without BAF ❌
Instead, transcription relies on EP300 via the SS18 QPGY domain
www.biorxiv.org/content/10.6...
➑️ Coactivator targeting emerges as a new therapeutic strategy in synovial sarcoma 🎯
Team work from @banitolab.bsky.social and @uoe-igc.bsky.social

28.01.2026 10:20 πŸ‘ 22 πŸ” 16 πŸ’¬ 3 πŸ“Œ 0

Anyone know anything about Jennifer Harvey, who first isolated the virus containing HRAS (Harvey-Ras) at Mill Hill in 1967?

Prepping a lecture including the discovery of Ras oncogenes and wanted to add pics of the scientists involved.

The Internet has NOTHING

#sciencehistory #forgottenwomen

23.01.2026 10:17 πŸ‘ 11 πŸ” 10 πŸ’¬ 9 πŸ“Œ 2

Very cool! Can't wait to see single-cell TimeVault 🀩

23.01.2026 00:22 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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A genetically encoded device for transcriptome storage in mammalian cells Understanding how cells make decisions over time requires the ability to link past molecular states to future phenotypic outcomes. We present TimeVault, a genetically encoded system that records and s...

πŸ§¬πŸ”¬@science.org A genetically encoded device for #transcriptome storage in mammalian cells | Science www.science.org/doi/10.1126/... @broadinstitute.org

15.01.2026 20:30 πŸ‘ 55 πŸ” 25 πŸ’¬ 1 πŸ“Œ 3
Yes, this is where you would work (the round building, not the boat)

Yes, this is where you would work (the round building, not the boat)

We are looking for a postdoc to join our team! If you're interested in translating a cutting edge genomics technology (www.nature.com/articles/s41...) to real-life applications in hematology, this is for you. We offer a unique working environment ON THE BEACH: recruitment.crg.eu/content/jobs...

20.11.2025 09:36 πŸ‘ 17 πŸ” 16 πŸ’¬ 0 πŸ“Œ 3
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EASTBIO - Dissecting CIC::DUX4 oncogenic circuitry through single-cell perturbation profiling and network inference at University of Edinburgh on FindAPhD.com PhD Project - EASTBIO - Dissecting CIC::DUX4 oncogenic circuitry through single-cell perturbation profiling and network inference at University of Edinburgh, listed on FindAPhD.com

We have an exciting PhD opportunity through the EASTBIO programme, co-supervised with Diego OyarzΓΊn. This project combines synthetic and systems biology to uncover the gene-regulatory circuitry hijacked in a cancer model. We’re looking for candidates with a strong interest in functional genomics.

19.11.2025 13:15 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1
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Why we made Affinity free, and how we’ll keep it that way We’ve made Affinity completely free, empowering professional designers with studio-grade creative software, supported by Canva’s sustainable ecosystem.

I'm a longtime fan of Affinity Designer as an affordable Illustrator-killer for figures, and... it's now free?! www.canva.com/newsroom/new...
Highly recommended if you're sick of paying Adobe $. Maybe Canva can buy NPG too and get rid of the OA fees.

18.11.2025 23:28 πŸ‘ 40 πŸ” 10 πŸ’¬ 1 πŸ“Œ 4
Job opportunity postodoctoral research fellow closing 18th November 2025

Job opportunity postodoctoral research fellow closing 18th November 2025

πŸ“£Job Opportunity: Develop machine learning of cellular automata models with applications to in vitro developmental biology.
More info: edin.ac/49Mr7ZQ

12.11.2025 14:30 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Congratulations @nsbenab.bsky.social and fellow experts joining the Independent Scientific Advisory Panel! πŸ‘
@cmvm-edinburghuni.bsky.social

12.11.2025 15:16 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Beautiful (jaw-dropping πŸ˜‰) work from Hannah Long’s group revealing how Neandertal enhancers influence facial morphology!

10.11.2025 11:42 πŸ‘ 7 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I guess I need to apologize to the writers of Alien: Prometheus. it turns out scientists really do touch everything like that

08.11.2025 16:30 πŸ‘ 2661 πŸ” 795 πŸ’¬ 35 πŸ“Œ 26
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πŸ₯This Wednesday , in #FragileNucleosome seminar, we are excited to host @hannahlong.bsky.social and @jeffvierstra.bsky.social to tell us about amazing work they are doing!
πŸ—“οΈRegister here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

03.11.2025 12:03 πŸ‘ 20 πŸ” 12 πŸ’¬ 0 πŸ“Œ 0