Monika Szpunar

The Design of a Randomized Controlled Active Comparator Strategy Trial for Gout: Treat to Target Serum Urate Versus Treat to Avoid Symptoms. Graphical abstract created with BioRender.

Randomized controlled active comparator strategy trial is proposed to address whether treating to a target serum urate vs treating to avoid symptoms is more effective for optimal management of gout

ACR Open Rheumatology
doi.org/10.1002/acr2...
#Medsky #Rheumsky #trialdesign #gout

Amazing presentation at CRA by @susanbartlett.bsky.social on the importance of addressing physical and emotional symptoms early on in rheumatoid arthritis because they may indicate a less favourable prognosis @arthritisresearch.bsky.social #CATCHcohort

Evidence for cytotoxicity and mitochondrial dysfunction in human lung cells exposed to biomass burning aerosol constituents: Levoglucosan and 4-nitrocatechol Biomass burning (BB) emissions are one of the largest sources of carbonaceous aerosol, posing a significant risk as an airway irritant. Important BB m…

Biomass burning—whether from wildfires, wood stoves or agricultural fires—sends massive amounts of tiny particles and chemicals into the air. These emissions are not just an environmental issue; they pose serious health risks, especially for our lungs.

www.sciencedirect.com/science/arti...

We welcome #ASM25 keynote speaker Dr. Muhammad Mamdani of @uoft.bsky.social in #CRArthritis 7. Join us as he shares info on how to make artificial intelligence in medicine a reality.

Watch now: youtu.be/VgVDqfFG42Q

#AI #artificialintelligence @arthritispower.bsky.social @schroeder-uhn.bsky.social

This year's AHPA Pre-course featured @jwphysio.bsky.social. In #CRArthritis 5, Ellen from ACE interviews Dr.Whittaker about
SOAR - a virtual #knee health program for those w/⬆️ risk of #osteoarthritis from knee injury.

Watch now: youtu.be/MecksJAmJMs

@oaactionalliance.bsky.social

Had a great time today touring @arthritisresearch.bsky.social scientist Dr. May Choi's Artificial Intelligence Autoimmune Diagnostics Lab at the McCaig Institute @ucalgary.bsky.social

Monogenic causes and clinical phenotypes of lupus and Behçet syndrome. ELF, E74-like ETS transcription factor; PFIT, periodic fever, immunodeficiency, and thrombocytopenia; RELA, v-rel reticuloendotheliosis viral oncogene homolog A; TLR, Toll-like receptor; TRIAD, trisomy 8–associated autoinflammatory disease

Pathways involved in monogenic systemic lupus erythematosus. ACP, acid phosphatase; ADAR, adenosine deaminases that act on RNA; BAFFR, B cell–activating factor receptor; Bc, B cell; cGAS, cyclic guanosine monophosphate–AMP synthase; COPA, coatomer subunit alpha; Dc, dendritic cell; dsDNA, double-stranded DNA; dsRNA, double-stranded RNA; ER, endoplasmic reticulum; IFN, interferon; IL-1R, interleukin-1 receptor; IRF, IFN regulatory factor; ISG, IFN-stimulated gene; MAVS, mitochondrial antiviral signaling protein; MDA, melanoma differentiation–associated protein; MyD, myeloid differentiation factor; NEMO, NF-κB essential modulator; NET, neutrophil extracellular trap; NIK, NF-κB–inducing kinase; NK, natural killer; PTPN, protein tyrosine phosphatase nonreceptor; RelB, v-rel avian reticuloendotheliosis viral oncogene homolog B; RIG, retinoic acid–inducible gene; SOCS, suppressor of cytokine signaling; STING, stimulator of IFN genes; Tc, T cell; TLR, Toll-like receptor, TNFR, tumor necrosis factor receptor; TREX, three-prime repair exonuclease; USP, ubiquitin-specific protease.

Pathways involved in Behçet syndrome. ACP, acid phosphatase; ADAR, adenosine deaminases that act on RNA; BAFFR, B cell–activating factor receptor; Bc, B cell; cGAS, cyclic guanosine monophosphate–AMP synthase; COPA, coatomer subunit alpha; Dc, dendritic cell; dsDNA, double-stranded DNA; dsRNA, double-stranded RNA; ER, endoplasmic reticulum; IFN, interferon; IL-1R, interleukin-1 receptor; IRF, IFN regulatory factor; ISG, IFN-stimulated gene; MAVS, mitochondrial antiviral signaling protein; MDA, melanoma differentiation–associated protein; MyD, myeloid differentiation factor; NEMO, NF-κB essential modulator; NET, neutrophil extracellular trap; NIK, NF-κB–inducing kinase; NK, natural killer; PTPN, protein tyrosine phosphatase nonreceptor; RelB, v-rel avian reticuloendotheliosis viral oncogene homolog B; RIG, retinoic acid–inducible gene; SOCS, suppressor of cytokine signaling; STING, stimulator of IFN genes; Tc, T cell; TLR, Toll-like receptor, TNFR, tumor necrosis factor receptor; TREX, three-prime repair exonuclease; USP, ubiquitin-specific protease.

Monogenic causes and clinical phenotypes of lupus and Behçet syndrome, and pathways involved
#Medsky