Silvia von Karstedt

SCLC-Lungenkrebs: Wissenschafter entdecken wichtigen Mechanismus Wissenschaftler der Universität zu Köln haben einen neuen Mechanismus entdeckt, der es ermöglicht, dass eine der aggressivsten Formen von Lungenkrebs der Behandlung entgeht, und eröffnet damit neue Mö...

🫁 Was macht das kleinzellige Lungenkarzinom (SCLC) so aggressiv? Forscher unter Leitung von @vonkarstedtlab.bsky.social vom @cecad.bsky.social / @unicologne.bsky.social haben einen neuen Mechanismus entdeckt, der dem #Lungenkrebs bei seiner Ausbreitung im Körper hilft. #SCLC

Inflammation fuels one of the most aggressive forms of cancer www.idw-online.de/-DS52AA

A caspase 8 deletion #SCLC mouse model promotes a neuronal progenitor-like cell state and pre-tumoral immunosuppression triggered by #necroptosis that promotes metastasis @vonkarstedtlab.bsky.social
@unicologne.bsky.social
@dtg-cologne.bsky.social
@cecad.bsky.social
doi.org/10.1038/s414...

@cecad.bsky.social

Lack of caspase 8 directs neuronal progenitor-like reprogramming and small cell lung cancer progression - Nature Communications Caspase 8 protein expression is largely absent in small cell lung cancer (SCLC) patients. Here, the authors generate a caspase 8 deletion SCLC mouse model and show that it promotes a neuronal progenit...

What a nice way to end 2025: absence of caspase 8 in #sclc leads to neuronal-like reprogramming and promotes #metastasis via #necroptosis driven #inflammatory response. Congratulations to Ariadne and collaborateurs @unicologne.bsky.social @dtg-cologne.bsky.social !
www.nature.com/articles/s41...

Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL) - Cell Death Discovery Cell Death Discovery - Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)

Happy to share an incredibly efficient collaboration with @gianmaria-liccardi.bsky.social
: Ibrutinib cooperates with #ferroptosis induction to kill #dlbcl
www.nature.com/articles/s41...

Functional synapses between neurons and small cell lung cancer - Nature Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.

The study titled “Functional synapses between neurons and small-cell lung cancer” was published in @nature.com 👇
www.nature.com/articles/s41...
#unicologne #uniklöln @cecad.bsky.social
#sclc #lungcancer #cancerresearch

Wired for growth: neuron–tumour signalling in the lung and brain increases growth of a hard-to-treat cancer Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.

Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer

go.nature.com/4gzoMmI

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature 17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

Happy to start at Bluesky with a post on our recent manuscript at @nature.com:

www.nature.com/articles/s41...

Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Hot topic in a hot environment! #FASEB @faseborg.bsky.social #Ferroptosis meeting organized by @olzmannlab.bsky.social and Scott Dixon is the place to be!

Come join us at this year's #FASEB conference on #Ferroptosis !
events.faseb.org/event/ferrop...

Today back to work from #maternityleave I found this left by my lovely team in my office @cecad.bsky.social

Aleksandra Trifunovic receives Max Delbrück Research Prize 2025 CECAD congratulates Professor Aleksandra Trifunovic on receiving the University of Cologne’s Max Delbrück Prize for her pioneering contributions to mitochondrial biology.

👏 Congratulations to Professor Aleksandra Trifunovic on receiving the Max Delbrück Research Prize 2025 from the University of Cologne for her groundbreaking work on #mitochondria, #aging, and cellular stress responses. A proud moment for #CECAD!

➡️ uni.koeln/Y6WSC

@unicologne.bsky.social

An atlas of ferroptosis-induced secretomes Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes

What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress
Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social

rdcu.be/ejp9C

Thank you 😀

And this paper is coming to you live from #maternityleave with the right supportive network! Just wanted to encourage #womeninscience #youngparents

Ferroptosis triggers mitochondrial fragmentation via Drp1 activation Cell Death & Disease - Ferroptosis triggers mitochondrial fragmentation via Drp1 activation

Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez!

rdcu.be/d7L66

Very pleased to see our latest study published at CDDpress. We show that #Seratrodast, an approved drug, is a suppressor of #ferroptosis by inihibiting lipid peroxidation.
Thanks to Jule, Wulf, and the rest of the team!

www.nature.com/articles/s41...

Action Intent Links | Bluesky Authors, websites, and apps can use action intent links to implement "Share on Bluesky" buttons, or similar in-app actions. Logged-in users will be directed to the corresponding action view in the Blu...

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how:

docs.bsky.app/docs/advance...

#AcademicSky #HigherEd #Altmetrics

🤣

Something always suspected now out in @natureportfolio.bsky.social
Take home mesage: eat and be merry for life is too short to outsmarten #epigeneticmemory

Hi Willian,
I would like to be added as well.
Cheers,
Silvia

Very interesting read for #SCLC aficionados!