@isaacli
Single-molecule biophysicist, building force-responsive DNA to study biology, love space exploration real & sci-fi. 🔬🧬🧫🌟🪐🚀 Associate Professor of Chemistry at UBC Okanagan, Canada Research Chair, Michael Smith Scholar 🍁🇨🇦 https://lilab.ok.ubc.ca/
The Biophysical Society of Canada is pleased to announce that Dr. Sarah Rauscher @sarahrauscher.bsky.social is the recipient of the 2026 Early Career Investigator Award. Congratulations!!
Our latest work on directional DNA hairpin 🧬 unzipping and mechanical anisotropy is out! Same sequence, different mechanical properties! By sequence design we can turn a classic two state folder into a soft, compliant molecule 🧸 that visit a stable transient ensemble! Have fun with the box!📦
We just uploaded a preprint on a new massively parallel single-molecule force spectroscopy method. No beads, no messy calibration - just pure DNA tethers pulling individual molecules while we watch them in real-time with fluorescence.
Check it out: www.biorxiv.org/content/10.1...
I didn’t connect the paper and the name! We read this paper with great interest, great work! Hope it gets published soon!! 👍
Thanks Sam, and this method is super low-cost! 😉
Latest from the lab: 🧬 Decoy DNA 🧬 can extend the lifetime of DNA-based tension probes >24h by outcompeting DNases and preserving signal integrity in live-cell tension imaging. This is a simple, general strategy for robust mechanobiology in DNase-rich environments. doi.org/10.1002/anie...
Wonderful visit to the University of Lethbridge -many thanks to Trushar @trushar7.bsky.social and Dylan for the kind hosting! Great discussions with researchers at the Chemistry and Biochemistry Department! 👍
Taking the group out for fun outside of the #BSC2025 @biophyscanada.bsky.social annual meeting, visited Niagara Falls, ran into a filming of a featured film, good times!
Congratulations 🎉 to Ryan, David, and Irving for winning two poster and a travel award at the @biophyscanada.bsky.social annual meeting! 👏
Congratulations to all the trainee award winners at the BSC 2025!
The 10th BSC annual meeting just wrapped up. We sincerely thank Cecile Fradin and the team of local organizers and volunteers at McMaster for making this a successful event! Looking forward to next year in Winnipeg!
SFU Physics professor Nancy Forde gathers a stack of booklets from students in a classroom
Congratulations to @sfuphysics.bsky.social professor Nancy Forde who has received the @canadianphysicists.bsky.social Medal for Excellence in Undergraduate Teaching, recognizing her innovative teaching methods, curriculum development and undergraduate research mentorship. cap.ca/programs/rec...
Check out our recent progress using 🧬 PAINT kinetics to decode molecular tension in super-resolution force imaging! 🔬 Great team effort from Seongho, Adam, Irving, and Kevin! 👏
#DNA-PAINT #tension #integrin #superresolution #adhesion
doi.org/10.1002/advs...
The 10th annual BSC meeting is coming up in Hamilton!
Don't miss the April 15 deadline for early registration, abstract submission, and travel awards.
Details & program: event.fourwaves.com/bsc2025/ #BSC2025
The 10th annual meeting of the Biophysical Society of Canada will be held May 20-23 at McMaster University in Hamilton, ON.
Check out the speaker lineup and programs here: event.fourwaves.com/bsc2025/
Early registration and abstract submission deadlines are April 15. #BSC2025
David Bakker from my group is talking to middle school students about our research on DNA and optical tweezers!🧬Great job, David, for bringing the latest science from UBCO to the grade 6-10 classrooms! career.sd83.bc.ca/2025/03/14/f...
#biophysics #outreach @ubcokanagan.bsky.social
We just published a review of the very recent progress in integrin force loading rate measurement using various molecular tension probes. Learn more about how this has advanced the field and what potential improvement lies ahead here: doi.org/10.1017/qrd....
#mechanobiology #integrin #tensionprobes
Heading to @biophysicalsoc.bsky.social for #bps2025! Looking forward to catching up with everyone!
A online environment for playing interactively with reaction-diffusion systems from Karl Sims
karlsims.com/rdtool.html
Hello little one, nice to meet you!
#daimon
Interesting read of the day:
Confronting risks of mirror life
www.science.org/doi/10.1126/...
Not a new paper, but still helps (1/2)
PhD survival guide @embopress.org
#PhD #PhDlife #academics #scisky #medsky
This is immensely fun to read
doi.org/10.1016/j.ij...
Coffee…made
Matlab…opened
Meetings…none
It’s gonna be a great day!
Hello sm community!! Thanks @hohlbeinlab.bsky.social for creating this!