Genes & Diseases Journal

📣 #ESMO26: The registration system is now open!
Join us at an event where multidisciplinary innovation meets global collaboration.
⏰ Big savings if you register before 22 July 2026

🔗 https://ow.ly/lg7S50YoACx

#esmomeetings

🚀 The 1st EORTC Summit in Clinical Cancer Research is coming!

AI, innovative methodologies, QOL, patient‑centricity, policy & more — all in one place.

📅 Save the date & help spread the word!
👉 www.eortc.org/summit

#EORTCSummit

This study reveals that the SOX9–MMP10–ECM axis drives tracheal fibrosis post-injury via the Wnt/β-catenin signaling pathway, highlighting the targeted inhibition of SOX9 as a potent therapeutic strategy in #TrachealStenosis.

#OpenAccess: doi.org/10.1016/j.ge...

#ERStress activates IRE1α–XBP1s to upregulate hIAPP transcription via an ACGT site, driving β-cell dysfunction in #type2diabetesmellitus (#T2DM); blocking #XBP1 splicing with MKC3946 lowers IAPP and improves β-cell survival.
#OpenAccess: doi.org/10.1016/j.ge...

This study reveals that Cdc42 deficiency causes enamel defects by disrupting mitochondrial function and inducing oxidative stress in the dental epithelium, highlighting its critical role in ameloblast differentiation.

#OpenAccess: doi.org/10.1016/j.ge...

This review describes the role of DEAD-box RNA helicases as critical hematopoiesis regulators, detailing how their post-transcriptional dysfunction promotes #HematologicalMalignancies and offers avenues for #CancerTherapy.

#OpenAccess: doi.org/10.1016/j.ge...

This review examines how bidirectional brain-body signaling and integrated immune-endocrine pathways drive #MajorDepressiveDisorder, providing perspectives for precision-oriented therapeutic strategies. @wakeforest.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

Join leading experts at the Ischemic Heart Disease Track at #ICNC2026 and explore the latest in #nuclearcardiology. From PET for sichemia, to CAD debates, post-revascularization chest pain, and INOCA, sharpen your skills for daily practice.

🔗 https://bit.ly/4l2SaDP

Primary care professionals play a critical role in the early diagnosis of NENs.
#ThinkNENs Program is here to help – and it's completely FREE.
✔ 60-minute CME-accredited module
✔ 7 languages
✔ Endorsed by leading NEN societies
Explore here: incalliance.org/think-nens/
#LetsTalkAboutNETs

📢 You can still join us today!
The ESTRO Gyn-SMART community invites you to a peer-to-peer discussion on late effects and supportive care in gynecological radiotherapy.

📅 Today | ⏰ 16:00–17:00 CET
💻 Online

ℹ️More info: https://bit.ly/4s0SXaz
👉 https://bit.ly/4slOTlN

#GynSMART #RadiationOncology

Elevated S100A9 in #HFpEF hearts drives oxidative stress and mitochondrial dysfunction; its deficiency restores #SIRT3 signaling, improves diastolic function, and reduces #hypertrophy and #fibrosis, supporting S100A9 as a therapeutic target.

#OpenAccess: doi.org/10.1016/j.ge...

Using integrated #scRNAseq, #Immunofluorescence, and functional validation, this study shows that the #Immunosuppressive #TumorMicroenvironment contributes to tumor aggressiveness in lymphovascular invasion-positive #PDAC.

#OpenAccess: doi.org/10.1016/j.ge...

A #disulfidptosis-based model for #HeadAndNeckCancer predicts survival and links low-risk #tumors to stronger immunity, while #multiomics highlight CXCL12–CXCR4 and identify #NQO1, with #dicoumarol boosting checkpoint therapy.

#OpenAccess: doi.org/10.1016/j.ge...

This review provides insights into #Epigenetic alterations in #Cancer and the #TumorMicroenvironment, outlining their roles in tumor progression and the therapeutic potential of epigenetic drugs and combination strategies.

#OpenAccess: doi.org/10.1016/j.ge...

This review highlights how NAD⁺/NADH and NADP⁺/NADPH homeostasis—regulated by NAD kinases, MESH1, NOCT, and circadian control—governs cellular metabolism and redox balance, with dysregulation linked to #cancer and #MetabolicDisease. #Nocturnin

#OpenAccess: doi.org/10.1016/j.ge...

This review elucidates the regulatory role of #m6A modification in #PCD pathways, highlighting its influence on #CardiovascularDisease progression and its emerging potential as novel diagnostic and #TherapeuticTarget.

#OpenAccess: doi.org/10.1016/j.ge...

Anyone can register for Thursday's FREE webinar on 'Unmasking Cancer Complexity: Gaining Multi-Dimensional Clarity through Multiomic Innovation'. 15:00 CET. Register: us02web.zoom.us/webinar/regi...

The IASLC Hot Topic Meeting returns this June, bringing together scientists, clinicians, and thought leaders to explore resistance to #immunotherapy in #lungcancer.
🗓️ Registration & abstracts open in March

Learn More: bit.ly/4rGmTc3

#HT26

Applications are open for the @conquercancer.bsky.social Young Investigator Award in Early Cancer Detection. provides funding for physicians during the transition from a fellowship or training program to a faculty appointment.

Apply by March 30, 2026: https://bit.ly/4aJG1Al
#CancerResearch

This review outlines #CorticalDevelopment and genetic causes of malformations of cortical development, highlighting PI3K/PTEN/AKT/mTOR signaling, advances in diagnosis and models, and emerging targeted therapeutic strategies. #IntellectualDisability

Read: doi.org/10.1016/j.ge...

This review elucidates the reciprocal regulation of #m6A modifications and #ncRNAs, highlighting their critical roles in RNA metabolism and their potential as #TherapeuticTargets in various human diseases.

#OpenAccess: doi.org/10.1016/j.ge...

This review examines lysine #crotonylation (Kcr) as a widespread #PostTranslationalModification regulating gene expression, #DNArepair, protein stability, and disease, highlighting crosstalk with #acetylation and other PTMs as therapeutic targets.

Read: doi.org/10.1016/j.ge...

An overview of the reciprocal feedback between #Mechanotransduction & #Epigenetic remodeling, illustrating how these loops govern cellular fate & disease progression, and their role as #Biomarkers & #TherapeuticTargets.

#OpenAccess: doi.org/10.1016/j.ge...

This review summarizes how #lncRNAs regulate the #AMPK signaling pathway by interacting with DNA, RNA, and proteins, shaping cellular energy homeostasis, metabolism, #aging processes, and the development of #AgeRelatedDiseases.

#OpenAccess: doi.org/10.1016/j.ge...

An overview of #Sonogenetics, detailing the fundamental properties of ultrasound and the role of ultrasound-sensitive proteins, highlighting its potential applications in #NeurologicalDisorders, #Cancer, and #StemCellTherapies.

#OpenAccess: doi.org/10.1016/j.ge...

This review explores how the #UbiquitinProteasomeSystem regulates BCR-ABL signaling, #leukemia stem-cell survival, and drug response in #ChronicMyeloidLeukemia, highlighting UPS targets to overcome #TKI resistance & improve outcomes. @zzu_china

#OpenAccess: doi.org/10.1016/j.ge...

🎙️ New #ESCCardioTalk episode

Another piece of the puzzle: long-term follow-up of conduction system pacing with Pranav Mankad & Kenneth Ellenbogen.

Discover what long-term data means for real-world pacing practice.
👉 https://bit.ly/4cftQfw

#Cardiology #Electrophysiology #ConductionSystemPacing

Controversies in the Management of Lung Cancer: Comorbidities | IASLC In this episode of Lung Cancer Considered, host Dr. Narjust Florez explores controversies in managing lung cancer patients with comorbidities – those often un ...

In this new episode, Dr. Narjust Florez discusses managing lung cancer in patients with complex comorbidities with Dr. Hina Khan and Dr. Corey Langer, recorded at TTLC 2026.
Topics include ECOG PS2, renal dysfunction, advanced age, and individualized treatment decisions.
🎧 Stream now: bit.ly/4qWIDzy

This review summarizes the significance of different small noncoding RNAs (#sncRNAs) in #CardiovascularDisease #Pathogenesis, detailing their regulatory roles and potential applications as #Biomarkers & #TherapeuticTargets.
#OpenAccess: doi.org/10.1016/j.ge...