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Seth Bordenstein

@symbionticism

Scientist, Huck Professor: Microbiome, Virome, Symbiosis, Evolution, Genetics, Phylosymbiosis, Holobiont, Wolbachia, Phage | Director of One Health Microbiome Center @psumbiome.bsky.social | SciEd: @wolbachiaproj.bsky.social | @holobiontbiology.bsky.social

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15.09.2023
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Latest posts by Seth Bordenstein @symbionticism

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The Wolbachia Avengers are still here. No blip in Happy Valley. Let’s goooooo. @vectorgen.bsky.social

06.03.2026 22:32 πŸ‘ 12 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Holobiont biology embraces the aspects of life that are relational, interdependent, and fluid. To view life and its many varieties as strictly a "fixed self" is two decades old; it deeply misses the ecoevolutionary nature written in cells, DNA, and traits of hosts and microbes, together.

01.03.2026 16:28 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

πŸ‘πŸΌπŸ‘πŸΌ

06.03.2026 00:19 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
2026 One Health Microbiome Symposium - The Huck Institutes (en-US)

Hope to see friends and newcomers there for a GRC-like conference but without all of the fuss, and with a super cheap price ($60 registration), global impact, and a distinct voice. www.huck.psu.edu/institutes-a...

04.03.2026 14:56 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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By fostering high-level dialogue at the critical intersection of human, agricultural, and environmental health, we are determined to find unity and common ground at this Symposium. Last call to register via the provided link/QR code and see what is possible when we come together as a diverse field.

04.03.2026 14:55 πŸ‘ 3 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Phyllosphere and rhizosphere microbiomes empower Nicotiana tobacum complex traits dissection and prediction | bioRxiv Understanding how plant-associated microbiomes interact with host genome variation to influence agronomic traits is essential for advancing microbiome⍰assisted crop improvement. In this study, we characterized the phyllosphere and rhizosphere microbiomes of 164 diverse Nicotiana tabacum accessions using 16S rRNA sequencing and integrated these data with host genomic variation and 22 agronomic traits. The two microbiomes exhibited distinct taxonomic structures, diversity patterns, and predicted metabolic functions. Microbiome genome⍰wide association studies identified extensive host genetic control over microbial abundance, including 49 shared genomic loci that explained nearly half of the heritable variation in both microbiomes. Microbiome⍰wide association studies revealed biologically meaningful associations between specific ASVs and agronomic traits. However, network analysis demonstrated that microbial sub⍰communities, rather than individual taxa, contributed substantially to phenotypic variation. Then, colocalization analysis further identified genetic variants jointly influencing microbial abundance and metabolite traits, highlighting potential host-microbe-trait causal links. Incorporating microbiome data into genomic selection models, we successfully improved prediction accuracy for several traits, especially plant architecture and flowering. Together, this work provides a comprehensive population⍰level framework linking host genetics, microbiome composition, and agronomic traits in tobacco, offering new insights for microbiome⍰informed breeding strategies.

Holobiont works -> Phyllosphere and rhizosphere microbiomes empower Nicotiana tobacum complex traits dissection and prediction | bioRxiv

01.03.2026 17:54 πŸ‘ 6 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0

Nice. Quantitative Hologenomics is the way forward for complex traits.

01.03.2026 20:39 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

🎯

26.02.2026 18:42 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Saving The Life We Cannot See | NOEMA Conservation has traditionally ignored the planet’s smallest life forms. Microbiologists are trying to change that β€” before it’s too late.

We have Red Lists for mammals, birds and trees.

But until now, nothing for microbes

Noema Magazine explores our IUCN Microbial Conservation Specialist Group

The life we cannot see may be the most important life of all.

www.noemamag.com/saving-the-l...

26.02.2026 18:04 πŸ‘ 8 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Yessss to Associate Prof Byndwin! πŸ‘πŸΌπŸ‘πŸΌ

21.02.2026 17:28 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

πŸ‘πŸΌπŸ‘πŸΌ

21.02.2026 17:27 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

You know them. We all have them - scientific heroes and heroines -> the ones who walk on water and inspire a generation of scholars.

Nominations are now open for the 2026 MICROBIOME MEDAL β€” for extraordinary contributions to the global scientific community in scholarship, mentorship, and service.

20.02.2026 17:16 πŸ‘ 5 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

πŸ‘πŸΌ

19.02.2026 12:45 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

πŸ€“

19.02.2026 12:45 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Wake up and smell the roses. This tiny, mighty, microscopic captain is a distant part of our human origin story.

19.02.2026 11:20 πŸ‘ 35 πŸ” 4 πŸ’¬ 2 πŸ“Œ 0

πŸ€ͺπŸ€™

16.02.2026 08:15 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

As scientists, we earn a living to logic trap the universe into revealing a secret about nature. If you’re doing this every week, you’ve already won a lot in life. Sunday night and in flow state…

16.02.2026 03:27 πŸ‘ 4 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

πŸ‘πŸΌ

14.02.2026 01:18 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Are you a Drosophila researcher & member of @genetics-gsa.bsky.social (at any level of training)?

Please vote in the Flyboard elections (we have an amazing slate of candidates) before Feb 20, 2026. Please check your email or go to this website to vote: genetics-gsa.org/2026-fly-boa...

Pl repost.

13.02.2026 19:26 πŸ‘ 33 πŸ” 28 πŸ’¬ 1 πŸ“Œ 1
Seth Bordenstein: A Unified View of Life: Holobiont Biology for the 21st Century
Seth Bordenstein: A Unified View of Life: Holobiont Biology for the 21st Century YouTube video by Dr. Seth Bordenstein

My seminar from the workshop at the Banff International Research Station for Mathematical Innovation. Biologists and mathematicians united to discuss the many opportunities for mathematical and eco-evo modeling of holobiont systems. A mix of world class minds here.

youtu.be/bFSTm4MxwRk?...

13.02.2026 18:49 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

I am seeking a postdoc to join my group at UCLA -- ideally the candidate would have some experience in either population genetics or microbes/microbiome (computational background needed). We have a range of projects and are happy to tailer to your interests. Please dm/email me if interested.

12.02.2026 19:18 πŸ‘ 53 πŸ” 95 πŸ’¬ 0 πŸ“Œ 0

Nuggets of information include thoughts on Darwin’s thoughts and history of symbiosis and speciation thereafter.

13.02.2026 02:45 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Seth Bordenstein: Darwin's Blindspot: The Symbiotic Basis of Speciation
Seth Bordenstein: Darwin's Blindspot: The Symbiotic Basis of Speciation YouTube video by Dr. Seth Bordenstein

#DarwinDay The "Origin of Species" is deeply enriched with a symbiotic lens. Here's a 15 minute seminar from @BIRS_Math on 25 yesrs of peeling back two layers of speciation to show reproductive and gut microbes have agency in the formation of new host species. youtu.be/DBlkt8UXc_8?...

12.02.2026 13:15 πŸ‘ 8 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Science peak ⛰️ Incredible to visit @banffcentre.bsky.social International Research Station w/ world-class theoreticians, using modelling to unravel the eco-evolution of holobionts. The more we model these units, the more creative the future. A wonderful meeting in Banff with models on the boards.

11.02.2026 18:04 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I am pleased to share that our paper is now published in Cell!
www.cell.com/cell/fulltex...
I am deeply grateful to all co-authors for making this possible.

This work was made possible through the guidance of Dr. Peer Bork. I share this in grateful memory and with deep respect for his mentorship.

09.02.2026 21:07 πŸ‘ 28 πŸ” 13 πŸ’¬ 1 πŸ“Œ 2

Ok, rant aside I really do have SO MUCH data that needs to be analyzed and would really benefit from machine learning type approaches.

So if you want to work to develop innovative approaches to study cnidarian holobionts/immunity, let’s write something up!

06.02.2026 01:28 πŸ‘ 8 πŸ” 5 πŸ’¬ 0 πŸ“Œ 0

Noice win!

06.02.2026 21:22 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Large-scale metagenomic analysis reveals host genetics shapes microbiomes in wild freshwater fish gut and skin Tang et al. performed a large-scale metagenomic analysis that provided a deeper understanding of the microbial composition of the gut and skin of wild freshwater fish as well as the phylosymbiosis rel...

Fish at it again. They have been a surprisingl case of #phylosymbiosis in a rising number of gut and skin appears. This study investigates 903 gut/skin samples from 121 species in southwest China under the Wild Freshwater Fish Microbiome Catalog. www.cell.com/cell-reports...

05.02.2026 13:36 πŸ‘ 9 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Professor of Nutritional Sciences APPLICATION INSTRUCTIONS: CURRENT PENN STATE EMPLOYEE (faculty, staff, technical service, or student), please login to Workday to complete the internal application process. Please do not apply here, a...

ENDOWED FULL PROFESSOR JOB! πŸ“£ Penn State is hiring a new Full Professor of NUTRITIONAL SCIENCES in the Department of Nutritional Sciences, College of Health and Human Development, and Huck Institutes of the Life Sciences at Penn State University.

psu.wd1.myworkdayjobs.com/PSU_Academic...

02.02.2026 00:45 πŸ‘ 1 πŸ” 3 πŸ’¬ 1 πŸ“Œ 0
Can Our Microbiome Change Our Genes? | One Health Microbiome Center #humanmicrobiome #microbiomes
Can Our Microbiome Change Our Genes? | One Health Microbiome Center #humanmicrobiome #microbiomes YouTube video by One Health Microbiome Center at Penn State

Science shorties, welcome.

We’ve been waiting for you

@erdavenport.bsky.social from @psumbiome.bsky.social is the 2nd release of our microbiome masterclass series!!

youtube.com/shorts/mzabY...

05.02.2026 01:58 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1