How do immune disease-relevant variants rewire gene regulation in CD4+ T cells?
In a collaboration led by Daniel Schraivogel and Lars Steinmetz at @embl.org, we combined two large-scale CRISPRi screens (4.1M cells) to map the downstream cascades of thousands of SNPs.
Very happy to see this out. 👏 @yinanwan.bsky.social
Bogdan Bintu and team.
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...
Pediatrics & Child Health has been publishing fictional case studies for 25 years and is now "correcting" them to acknowledge they are fictional. I have never seen anything like this.
retractionwatch.com/2026/03/03/c...
Out now on bioRxiv! 🧬🖥️
Dewi Moonen, @anniquec.bsky.social and a team led by Lars Steinmetz and Daniel Schraivogel at EMBL have mapped the downstream regulatory networks of thousands of immune disease-relevant variants in CD4+ T cells
www.biorxiv.org/content/10.6...
🧵 See 👇 our new preprint on shared and organ-specific gene expression programs of fibrotic diseases 🧬
📄 Paper: doi.org/10.64898/202...
📊 Explore the data: organfibrosis.saezlab.org
The brain drain continues – the U.S. has lost arguably its most important scientific awards ceremony:
arstechnica.com/science/2026...
When a US missile killed 160 children, president shits-a-lot claimed Iran stole the missile and fired at the school. When asked why he was the only one making this claim, he said "because I just don't know enough about it".
Go ahead. See if you can make this make sense.
(Source: RB Hubbell)
MYTH: As commander-in-chief, Trump has the authority to take military action. FACT: It is unconstitutional for a U.S. president to declare war without the approval of the Knesset.
Trump’s War On Iran: Myth Vs. Fact https://theonion.com/trumps-war-on-iran-myth-vs-fact/
In Deutschland denken Frauen heute darüber nach, ihre Babys abzutreiben, weil die Wohnung zu klein ist. Keine bezahlbare Wohnung, keine Kinder. Und die CDU will die Partei von Familie und Heimat sein? In den 60er Jahren schuf die CDU "das Wohnungswunder"! Für Adenauer war…
We are are searching a scientific manager for the ZMBH. This position requires a life sciences PhD & excellent German skills, therefore the advertisement is formulated in German. Very good English skills are needed as well. You are welcome to share the ad:
www.academics.de/jobs/wissens...
Is the linear map of cell signaling a myth?
New research suggests the reality of cellular networks is more complex.
@savitski-lab.bsky.social & @saezlab.bsky.social combined experimental and computational expertise to test how we map kinase–substrate interactions.
www.nature.com/articles/s41...
Screenshot of an X post by Republicans Against Trump reporting claims that commanders at multiple U.S. bases told troops the Iran war is part of “God’s plan” and linked to Armageddon. Below is a photo of Trump standing with several evangelical leaders praying around him.
The religious right has infiltrated far into our military with disturbing consequences.
The main project of my PhD 🧬🔬 is out: we developed single-cell lentiMPRA, a lentivirus-based method to measure enhancer activity and transcriptomes at single-cell resolution. We then applied sc-lentiMPRA to fully synthetic enhancers 🧩...
🔗 doi.org/10.64898/202...
Now, synthetic enhancers with single cells - great work by @juruehle.bsky.social : www.biorxiv.org/content/10.6...
Screenshot of the "Does that use a lot of energy?" online app
Hannah Ritchie has built a fun little tool where you can compare energy usage of various products and activities.
This is super helpful imho, because it's so hard to develop intuitions even just about the scales involved here.
hannahritchie.substack.com/p/does-that-...
Chance and Consensus in Peer Review (1981) www.science.org/doi/10.1126/... tltle: it's a lottery system)
Our internal organs are evolutionary marvels. New technologies are transforming our understanding of the evolution of vertebrate organs. You can find more by reading here:
rdcu.be/e5EgU
#EvoBio #EvoDevo 🐟🦎🐢🦇🐊🦜
Democrats Wear White Flag Pins To SOTU To Indicate Surrender
Democrats Wear White Flag Pins To SOTU To Indicate Surrender
THERE’S POWER IN BOYCOTTING!
Thunderstorms can generate weak electrical discharges on the plants underneath, but until now, they had never been observed in nature
Press the Red Button, Dave. A small study at LANL has real-world #biosecurity relevance: evaluating whether AI can transfer tacit laboratory skill to novices. doi.org/10.59350/6e0...
📖 Our new pseudotime alignment tool ptalign identifies Wnt antagonist SFRP1 as central for glioblastoma cell activation, opening new avenues for patient stratification and therapeutic avenues.
🔗 lnkd.in/ees8bhNY
by @Leo Carl Foerster, Oguzhan Kaya et al.
#glioblastoma #pseudotime #neurobiology
ggannotate: interactively add annotations to your {ggplot2} plots by pointing and clicking github.com/MattCowgill/... #Rstats
Absolutely savage, I love it.
With all the excitement about AI giving us answers, we often forget that the real trick is to figure out what is the question.
8/ 🤘 For those about to rock (around the Christmas tree), we salute you 🎸🎄: Isabelle Seufert & our team from @dkfz.bsky.social & BioQuant & @akispapantonis.bsky.social, Philipp Mallm, @s-anders.bsky.social & Petros Kolovos labs with support from @spp2202.bsky.social & @mspacealliance.bsky.social.
1/ 🎄 We got our Christmas present today: "Two distinct chromatin modules regulate proinflammatory gene expression" is now published @natcellbio.nature.com doi.org/10.1038/s415.... Our study introduces a scATAC-seq-based framework for genome-wide analysis of gene regulation features.
Screenshot from project 2025 that says By statute or regulation, CDC guidance must be prohibited from taking on a prescriptive character. For example, never again should CDC officials be allowed to say in their official capacity that school children "should be" masked or vaccinated (through a schedule or otherwise) or prohibited from learning in a school building. Such decisions should be left to parents and medical providers. We have learned that when CDC says what people "should" do, it readily becomes a "must" backed by severe punishments, including criminal penalties. CDC should report on the risks and effectiveness of all infectious disease-mitigation measures dispassionately and leave the "should" and "must" policy calls to politically accountable parties. Conflicts of Interest. There was a time when the CDC could not take money
It is utterly catastrophic that RFK Jr. plans to end CDC recommendations for most childhood vaccines.
It’s a betrayal of science, ethics, compassion, and the people of the United States.
And it was also a specific goal of Project 2025 (page 254).
