Sharma Lab

RNA Splicing Lab - JOIN US Are you interested in investigating basic mechanisms in splicing regulation and gene expression? Our research group was launched in September 2024 and is hosted at the Institute of Molecular Infection...

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us
Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! 🧪🧫

🚨We are looking for a coordinator located at @uni-wuerzburg.de for our new excellence cluster NUCLEATE - Cluster of Nucleic Acid Sciences and Technologies 👇
www.uni-wuerzburg.de/fileadmin/03...
Deadline: Jan 31 st, 2026

Uropathogenic Escherichia coli invade luminal prostate cells via FimH–PPAP receptor binding - Nature Microbiology Uropathogenic Escherichia coli infection of a murine prostate organoid model reveals a bacterial FimH–host prostatic acid phosphatase adhesin-receptor interaction enabling invasion and replication wit...

Our first paper is out today in @natmicrobiol.nature.com!

We introduce a prostate organoid model and show that UPEC invades prostate cells via FimH binding to the prostate-specific protein PAPP. A step toward targeted therapies against bacterial prostatitis. 🎉

#UTI #UPEC #Organoids #AMR

🧪We are hiring #MicroSky🧪
Postdoc position in #microbiology #bioinformatics for our @volkswagenstiftung.de funded MOMENTUM project. Join us to study bacterial gene expression with #microfluidics and #microscopy.
➡️ www.uni-wuerzburg.de/fileadmin/03290000/2025/Postdoc_MOMENTUM_Sharma_2025-08.pdf

Freude über den Doppelerfolg: Zwei Würzburger Forschungsvorhaben haben sich im Exzellenzwettbewerb durchgesetzt und erhalten Mittel aus der begehrten Millionenförderung. Von links: Caroline Kisker (Würzburger Koordinatorin von NUCLEATE und Vizepräsidentin), Cynthia Sharma (Würzburger Speakerin von NUCLEATE), Ralph Claessen (Würzburger Speaker von ctd.qmat) und Universitätspräsident Paul Pauli (Bild: Jonas Blank / JMU)

Erfolg auf ganzer Linie: zwei Exzellenzcluster für Würzburg! 🥂🚀
Im Rahmen der #ExStra wird nicht nur der Quantenphysik-Cluster ctd.qmat weiterhin gefördert. Mit NUCLEATE, einem Forschungsprojekt zu Nukleinsäuren, kommt noch ein zweiter Cluster hinzu!
➡️ go.uniwue.de/xstra25

Functional genomics of Campylobacter-host interactions in an intestinal tissue model reveals a small lipoprotein essential for flagellar assembly Campylobacter jejuni is currently the most common cause of bacterial gastroenteritis worldwide. However, its genome provides few clues about how it interacts with the host. Moreover, infection screens...

New preprint on our #Campylobacter Tn-seq screen in a 3D tissue model revealing a #smallprotein crucial for motility by @monaalzheimer.bsky.social @kathrinfroschauer.bsky.social @campy-bara.bsky.social together with the Beeby & Hendrixson labs: 👇
www.biorxiv.org/content/10.1...
@uni-wuerzburg.de

Complementary Ribo-seq approaches map the translatome and provide a small protein census in the foodborne pathogen Campylobacter jejuni - Nature Communications Bacterial genomes still contain many hidden and uncharacterized genes. Using complementary Ribo-seq approaches, Froschauer, Svensson et al. here annotate start and stop codons of Campylobacter jejuni,...

We are happy to share our new paper on the #Campylobacter translatome out now in @naturecomms.bsky.social. Many congrats to @kathrinfroschauer.bsky.social & @campy-bara.bsky.social and all collaboration partners! #SPP2002 #smallproteins @uni-wuerzburg.de

www.nature.com/articles/s41467-025-58329-w