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Megan Seddon

@meganismofaction

ID Pharmacist πŸ¦ πŸ’ŠπŸ§«βœ¨ Interested in Antimicrobial Resistance, PK/PD, Experiential PharmEd, Humanism in PharmEd, Narrative Medicine/Pharmacy. Views = my own. New handle, formerly ShorterSeddonRx

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11.11.2024
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Latest posts by Megan Seddon @meganismofaction

Echo the orange cat standing next to a Charlie Brown-esque potted fir tree. The tree is decorated with multi-colored lights, royal blue and pearl white ball ornaments, and a snow flake ornament towards the top.

Echo the orange cat standing next to a Charlie Brown-esque potted fir tree. The tree is decorated with multi-colored lights, royal blue and pearl white ball ornaments, and a snow flake ornament towards the top.

Happy Holidays from me and Echo πŸ©΅πŸŽ„πŸˆ

Pets of #IDSky #PharmSky #SIDP #MedSky

24.12.2024 21:26 πŸ‘ 19 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

😻😻😻 So cute!!!

14.12.2024 19:12 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Adding mine in πŸ˜„ happy Caturday from Wheatley and Dewey!

14.12.2024 19:10 πŸ‘ 5 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Echo the orange cat asleep on a light blue fluffy blanket, the picture of ultimate rest and relaxation. He is laying on his side facing the camera and pink toe beans on one of his front paws are peaking out from folds of the blanket.

Echo the orange cat asleep on a light blue fluffy blanket, the picture of ultimate rest and relaxation. He is laying on his side facing the camera and pink toe beans on one of his front paws are peaking out from folds of the blanket.

I aspire to my cat’s level of relaxation 🧘 Happy #Caturday from me and Echo πŸ©΅πŸ¦‹

Pets of #IDSky #PharmSky #MedSky #SIDP

14.12.2024 18:03 πŸ‘ 12 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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1/ 10th Day of Pharmacy Advent: IV Iron therapy in concurrent infection.
Let's delve into the complexities of using IV iron during active severe infections & potential risks involvedπŸ‘‡

Shout out & thnx to @kirchoff.org for topic idea! πŸ™

#medsky #pharmsky #EMsky #IDsky #HMsky #nephrosky

10.12.2024 18:17 πŸ‘ 16 πŸ” 6 πŸ’¬ 1 πŸ“Œ 3

Happening today yall with the amazing Dr UchΓ© Blackstock. We hope you’ll join!!

10.12.2024 17:16 πŸ‘ 6 πŸ” 2 πŸ’¬ 3 πŸ“Œ 0
Pale, pale yellowish bloom on a Christmas cactus (maybe a Thanksgiving cactus πŸ€·πŸΌβ€β™€οΈ). Hot pink stamen (pretty sure that’s the stamen?). No other buds to be found on the entire plant. A pleasant surprise.

Pale, pale yellowish bloom on a Christmas cactus (maybe a Thanksgiving cactus πŸ€·πŸΌβ€β™€οΈ). Hot pink stamen (pretty sure that’s the stamen?). No other buds to be found on the entire plant. A pleasant surprise.

Pale, pale yellowish bloom on a Christmas cactus (maybe a Thanksgiving cactus πŸ€·πŸΌβ€β™€οΈ). Hot pink stamen (pretty sure that’s the stamen?). No other buds to be found on the entire plant. A pleasant surprise.

Pale, pale yellowish bloom on a Christmas cactus (maybe a Thanksgiving cactus πŸ€·πŸΌβ€β™€οΈ). Hot pink stamen (pretty sure that’s the stamen?). No other buds to be found on the entire plant. A pleasant surprise.

Taken by surprise by this single bloom on one of my Christmas cacti today. I can’t find another bud on the entire plant πŸͺ΄ πŸ’š

07.12.2024 17:17 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Echo the orange cat, stretched out on the bed, head snuggled into my forearm, eyes closed, content, front legs reaching towards me, white whiskers catching the light coming in through the gap in the curtains.

Echo the orange cat, stretched out on the bed, head snuggled into my forearm, eyes closed, content, front legs reaching towards me, white whiskers catching the light coming in through the gap in the curtains.

Echo wishes you some rest on this #Caturday 😴🐈

Pets of #IDSky #PharmSky #SIDP #CatSky

07.12.2024 15:47 πŸ‘ 10 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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1/ On the 6th day of Pharmacy Advent, let’s talk re: communication

Today, I’m sharing aπŸ’ŽI learned in palliative care that I carry into ED practice. This tool has profoundly shaped how I approach sensitive conversations w/ pts & peers. Let’s dive inπŸ‘‡ #medsky #pharmsky #nursesky #emimcc #HMsky #GPsky

06.12.2024 21:02 πŸ‘ 22 πŸ” 7 πŸ’¬ 2 πŸ“Œ 0
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2024 is coming to a close! Check out our SIDP Wrapped! 🎊 #stewardship #infectiousdiseases

05.12.2024 23:00 πŸ‘ 25 πŸ” 8 πŸ’¬ 0 πŸ“Œ 1
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it’s the happiest Thursday because @sidpharm.bsky.social and the @escmid.bsky.social PK PD study group are bringing back ICAAC (in spirit)!!!!

Registration will open next week! The Midwest in the summer is magical - come join us!

sidp.org/page-1543694

#idsky #amssky #pharmsky

05.12.2024 12:52 πŸ‘ 38 πŸ” 12 πŸ’¬ 2 πŸ“Œ 4

Hi #IDSky - Tulane ID has unfilled fellowship spots. We're looking for applicants to join starting 7/2025

We offer:
-Diverse training across 3 hospital sites
-Broad clinical exposure, including HIV, tropical diseases, and transplant

(1/2)

05.12.2024 14:08 πŸ‘ 8 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0

🚨 2 Open ID Fellowship Spots at the University of Utah! 🚨
πŸ₯ Train in a top-tier hospital with cutting-edge infrastructure
πŸŒ„ Live in stunning Salt Lake City with an unbeatable lifestyle
πŸ“© Email Adele.Hamilton@hsc.utah.edu & Adrienne.Carey@hsc.utah.edu to apply!

04.12.2024 20:40 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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High rates of Mycoplasma pneumoniae ("walking pneumonia") in Ontario, 2024, especially in those age 5-17.

16.3% of a subset of 135 specimens had mutations that suggest resistance to macrolide antibiotics.

Link: tinyurl.com/3ddnd29w #IDSky #MedSky

04.12.2024 19:22 πŸ‘ 44 πŸ” 17 πŸ’¬ 4 πŸ“Œ 1

Some great references below on UTI/ASB! #IDSky #UTISky

Also, please make the β€œUA positive for UTI” diagnosis go away 😭

04.12.2024 13:35 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

🧡2 words likely to trigger most ID/ASP clinicians = β€˜asymptomatic bacteriuria’ (ASB). 😱 Except for pregnant persons & those undergoing certain urologic procedures, there's no 🚫 clear evidence of benefit of treatment & some signal for harm in other populations. #IDSky #RxSky #MedEd #PharmEd 1/n

02.12.2024 18:26 πŸ‘ 14 πŸ” 2 πŸ’¬ 2 πŸ“Œ 2

There are so many awesome studies in this area - what are some of your favorites?

02.12.2024 18:26 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Hopefully these data will help reframe the risk-benefit ratio of ASB treatment. Evidence suggests risks of not treating are less than feared & perhaps treating may actually increase risk of subsequent symptomatic UTI by killing off colonizing ASB strains which may have a protective role. 10/10 πŸ”š

02.12.2024 18:26 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Defining a Molecular Signature for Uropathogenic versus Urocolonizing Escherichia coli: The Status of the Field and New Clinical Opportunities - PubMed Urinary tract infections (UTIs) represent a major burden across the population, although key facets of their pathophysiology and host interaction remain unclear. Escherichia coli epitomizes these obst...

Perhaps in the future we will be able to distinguish colonizing ASB strains from uropathogenic strains of bacteria. 9/n
pubmed.ncbi.nlm.nih.gov/31794727/

02.12.2024 18:26 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria - PubMed In patients with ASB, bacteremia from a presumed urinary source was rare, occurring in less than 1% of patients with AMS. A personalized, risk-based approach to empiric therapy could decrease unnecess...

A large cohort study suggests risk of bacteremia from a urinary source in hospitalized pts w/ASB is very low. The decision to treat or not always comes down to the risk-benefit ratio for the pt in question - perhaps these data may help further reframe that risk. 8/n
pubmed.ncbi.nlm.nih.gov/38477915/

02.12.2024 18:26 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Bacterial interference for prevention of urinary tract infection: a prospective, randomized, placebo-controlled, double-blind pilot trial - PubMed This prospective, randomized, placebo-controlled, double-blind pilot trial examined the efficacy of bacterial interference in preventing urinary tract infection (UTI) in 27 patients with spinal cord i...

The corollary to these data are small RCTs that have studied purposeful inoculation of ASB strains into the bladders of those at high risk of recurrent UTIs, like persons with spinal cord injury, with positive findings. 7/n
pubmed.ncbi.nlm.nih.gov/16231269/
pubmed.ncbi.nlm.nih.gov/20483149/

02.12.2024 18:26 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Kaplan-Meier curves at 12 and 40 months of follow-up, showing that patients receiving asymptomatic bacteriuria treatment were more likely to develop subsequent symptomatic UTI.

Kaplan-Meier curves at 12 and 40 months of follow-up, showing that patients receiving asymptomatic bacteriuria treatment were more likely to develop subsequent symptomatic UTI.

Might this ability of ASB strains to outcompete uropathogens explain the signal in the literature for *increased* risk of symptomatic UTI following ASB treatment? πŸ€” 6/n
pubmed.ncbi.nlm.nih.gov/22677710/
pubmed.ncbi.nlm.nih.gov/26270684/

02.12.2024 18:26 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Competitive fitness of asymptomatic bacteriuria E. coli strain 83972 against uropathogens in human urine - PubMed Urinary tract infection (UTI) is one of the most common bacterial infections worldwide. The main causative agent of UTI is uropathogenic <i>Escherichia coli</i> (UPEC). There is an immediate need for ...

In fact, the ASB strain E. coli 83972 has been found to outcompete many uropathogens! 🦠 5/n
pubmed.ncbi.nlm.nih.gov/38780216/

02.12.2024 18:26 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Figure 2 from linked article that contrasts an asymptomatic bacteriuria (ASB) strain of E. coli, E. coli 83972, and uropathogenic or UPEC E. coli. The ASB strain lacks adhesins and therefore cannot ascend to the upper urinary tract. It maintains urine colonization due to its fast growth and potentially also biofilm formation. Host immune response is not triggered in response to these ASB strains.

Figure 2 from linked article that contrasts an asymptomatic bacteriuria (ASB) strain of E. coli, E. coli 83972, and uropathogenic or UPEC E. coli. The ASB strain lacks adhesins and therefore cannot ascend to the upper urinary tract. It maintains urine colonization due to its fast growth and potentially also biofilm formation. Host immune response is not triggered in response to these ASB strains.

There are well-characterized ASB strains, like E. coli 83972, that lack virulence factors such as adhesins and are distinct from uropathogenic E. coli. 4/n
pubmed.ncbi.nlm.nih.gov/17502385/

02.12.2024 18:26 πŸ‘ 4 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Urinary Microbiome: Yin and Yang of the Urinary Tract - PubMed The application of next generation sequencing techniques has allowed the characterization of the urinary tract microbiome and has led to the rejection of the pre-established concept of sterility in th...

The urine is not sterile πŸ™… - there is a diverse urinary microbiome or 'urobiome.' 3/n
pubmed.ncbi.nlm.nih.gov/34084752/

02.12.2024 18:26 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Performance of Urinalysis Parameters in Predicting Urinary Tract Infection: Does One Size Fit All? - PubMed In a multihospital cohort study of 3392 patients, positive urinalysis parameters had poor positive predictive value for diagnosing urinary tract infection (UTI). Combined urinalysis parameters (pyuria...

β€œUA positive for UTI” may often be documented, but in a multihospital cohort of >3K people, positive UA parameters had a poor positive predictive value for UTI. 2/n
pubmed.ncbi.nlm.nih.gov/38666412/

02.12.2024 18:26 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

🧡2 words likely to trigger most ID/ASP clinicians = β€˜asymptomatic bacteriuria’ (ASB). 😱 Except for pregnant persons & those undergoing certain urologic procedures, there's no 🚫 clear evidence of benefit of treatment & some signal for harm in other populations. #IDSky #RxSky #MedEd #PharmEd 1/n

02.12.2024 18:26 πŸ‘ 14 πŸ” 2 πŸ’¬ 2 πŸ“Œ 2
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Say His Name: Robert Rayford - AIDS Foundation of Chicago Resetting the timeline and narrative around the HIV EpidemicΒ  In the annals of medical history, certain names echo loudly, while others remain shrouded in obscurity, their stories consigned to the for...

Have you heard of Robert Rayford?
He was the earliest confirmed case of HIV/AIDS in North America. His story reshapes how we understand the epidemic and reminds us to fight for health equity.I encourage you to read this piece of #HIV history. A 🧡
#WorldAIDSDay2024
www.aidschicago.org/say-his-name...

01.12.2024 12:54 πŸ‘ 44 πŸ” 15 πŸ’¬ 5 πŸ“Œ 1