Anna B. Szabo

🔈We’re looking for a Junior Scientist (neuroscience, biomedical engineering, or cognitive neuroscience) with fMRI experience to join the Genzel Lab in Nijmegen for a new project exploring how sleep, memory, and network hyperexcitability interact in Alzheimer’s disease. More info in the job ad below👇

🫁We also found that sleep-disordered breathing and precuneus atrophy may help flag patients at higher risk, offering potential guidance for more targeted screening. 🧵5/5

Our observations indicate that atypical spike morphologies in AD may fall outside current diagnostic criteria designed for primary epilepsy. This highlights the need for a methodological consensus tailored to Alzheimer’s pathology. 🧵4/5

💤Here, we used overnight video-EEG-PSG with extended temporal electrodes and a tailored clinical questionnaire to study this comorbidity and push current detection limits. Epileptic events appeared in only 10% of patients, though several more reported symptoms suggestive of potential seizures. 🧵3/5

🧠Sleep-predominant epileptic activity is increasingly recognized as a possible disease-accelerating mechanism in Alzheimer’s disease - yet its prevalence, underlying mechanisms, and risk factors remain poorly understood. 🧵2/5

Refining Detection of Subclinical Epileptiform Activity in Alzheimer's Disease: A Case-Control Study and Call for a Consensus Objective: Sleep-predominant network hyperexcitability is increasingly recognized as a potential disease-accelerating comorbidity in Alzheimer's disease (AD). However, its prevalence and risk-factors ...

🚨Our preprint on the prevalence, characteristics, and potential risk factors of epileptic activity in Alzheimer’s disease is out! www.medrxiv.org/content/10.1... 🧵1/5

Bidirectional modulation of sleep and wakefulness via prefrontal cortical chemogenetics The drive to sleep is inescapable but its biological substrate remains largely elusive. Until recently, the search for sleep centres in the mammalian brain focussed on subcortical neurons that promote...

www.biorxiv.org/content/10.1...

Call for Contributors: ESRS Manual for the recording and analysis of sleep in laboratory rodents | ESRS The absence of standardised methodologies for measuring and scoring sleep in mice and rats continues to pose challenges for reproducibility and data

🚨Open Call for Fellow Sleep Researchers!🐭
💤The @esrs.bsky.social has just launched an initiative to develop a consensus-based manual for recording and analysing sleep in laboratory rodents.
🔗Are you interested in joining us on this exciting journey?Apply here before 1 August: lnkd.in/dWfMabRr

Prediction of mental health risk in adolescents - Nature Medicine Using longitudinal survey and neuroimaging data from more than 11,000 adolescents in the United States, a machine learning model shows promising performance in identifying individuals at greater risk ...

Sleep disturbance as the strongest predictor of subsequent psychiatric disorders in young people (greater than family history and adverse childhood experiences). Sleep disturbance is modifiable, a key node for intervention.
www.nature.com/articles/s41...

Don’t miss our latest 📝 with @chrislisgaras.bsky.social & Rick Staba on high-frequency oscillations in preclinical 🧠 disease models, with guidelines for recording, detection and analysis. journals.sagepub.com/doi/10.1177/...

sleep workshop

🌍🧠 💤Join us on June 20th, 2025, in Oslo for a workshop that bridges System Neuroscience and Sleep Research in partnership with @esrs.bsky.social @ncmbm.bsky.social @sainsburywellcome.bsky.social @uio.no @KU
A satellite of the FENS regional meeting, register here:
frm2025oslo.no/basic-sleep-...

Interictal network dysfunction and cognitive impairment in epilepsy - Nature Reviews Neuroscience Epilepsy is often associated with cognitive comorbidities that lack effective treatment options. In this Review, Gelinas and Khodagholy discuss how physiological neural networks involved in cognition ...

www.nature.com/articles/s41...

Is it time to revisit the scoring of Slow Wave (N3) Sleep? Abstract. The use of a fixed electroencephalogram (EEG) amplitude threshold of 75 µV for labelling slow waves is a subject of ongoing discussion given EEG

💤The 75µV threshold for scoring N3 sleep may not be a one-size-fits-all criterion, as age- and sex-related changes of slow wave amplitude may create bias, suggests a study by @shaun2406.bsky.social & Prof L Tarassenko from @oxengsci.bsky.social, and Prof S Kyle & @ Dr R Sharman from our team.🧵1/3

We are hiring! — Genzel Lab

We have an open post doc position funded by an ERC Consolidator grant. It is 3 years full-time and we are looking for someone with expertise in molecular methods (engram tagging/opto/DREADDs/Immunohistochemistry) to join our big, team-science projects. www.genzellab.com/we-are-hiring

4th MARCH is the deadline for applications for our MSc/PGDip Sleep Medicine

Bursaries are available for eligible applicants who apply by the March deadline

Sign up to one of our info sessions on 13th FEB at 12pm or 7pm UK time to find out more about our courses:

www.scni.ox.ac.uk/forms/inform...

Always happy to discuss about the various fascinating facets of sleep💤! This time it was all about the ever-expanding field of wearables⌚️& their potential use in sleep medicine/research. Thanks to the participants for their enthousiasm throughout our 2-day Sleep Measurement masterclass at @ox.ac.uk!

Hope the students also enjoyed the first day of our Sleep Measurement masterclass at @ox.ac.uk ! More to come on Day 2 later! #Sleep #SleepMedicine

Cartoon which mimics The Great Wave off Kanagawa, but the wave is made of research papers and the boat is full of lab coated researchers

I'm sure this Science story on how systematic reviews are threatened by paper mills is good, but the illustration by Sara Gironi Carnevale is great

saragironicarnevale.com

Story: https://www.science.org/content/article/systematic-reviews-aim-extract-broad-conclusions-many-studies-are-peril

#Communiqué 🗞️ Jusqu’au 31 janvier 2025, le CNRS invite le public à participer à une grande consultation nationale en partenariat avec Make.org.
Cette initiative inédite vise à recueillir les attentes des Français en matière de sciences.
👉 make.org/FR/consultat...

#SciencesPourDemain

Neuroscientists! A key message from the ALBA Network
Please help us spread the word and share this with your network!!!
Nominate (self-n allowed) a mid-career neuroscientist (5+ years post-PhD) for the ALBA-Roche Research Prize for Excellence in Neuroscience!
🔎http://loom.ly/_EvQvm4
🗓️20 January 2025