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sylvain Brisse

@sylvainbrisse

professor at Institut Pasteur. Bacterial genomics, vaccine-preventable diseases, antimicrobial resistance, bioinformatics and public heath applications. International capacity building and teaching. Klebsiella diphtheria whooping cough genomic librairies

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20.10.2024
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Latest posts by sylvain Brisse @sylvainbrisse

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Un an après Stand Up for Science, défendons l’université et les sciences, piliers de la démocratie Le mouvement Stand Up for Science, issu de la mobilisation inédite des universitaires français en solidarité avec leurs homologues américains, rappelle que les campus français aussi sont malmenés par ...

Aujourd’hui, @standupforscience.bsky.social fête son anniversaire. Signataire de la tribune "un an après".

Une mobilisation mondiale autour d'une évidence qui ne devrait jamais être discutée : la science n’est pas une opinion. C’est un pilier de la démocratie. 🧵👇🏻

www.liberation.fr/idees-et-deb...

07.03.2026 18:09 👍 3 🔁 1 💬 1 📌 0
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Molly Ingersoll: advocating for women's health and women's rights Molly Ingersoll has been head of a research team at the Institut Pasteur in Paris since 2012. This unfailingly optimistic microbiologist and immunologist is committed to revolutionizing our approach t...

Meet Molly Ingersoll, microbiologist & immunologist.
Her work shows how women and men can respond very differently to infections, and why sex-specific treatments are urgently needed.
She also speaks up about the invisible hurdles women face in science.
Follow her here @immunobladder.bsky.social

05.03.2026 13:52 👍 15 🔁 5 💬 0 📌 0

so great to see these novel great visualisation tools attached to BIGSdb - thanks Keith for your swift developer power 👍

04.03.2026 21:02 👍 2 🔁 0 💬 0 📌 0

➡️ preprint from the lab! Bacteria have loads of antiviral defences in their mobile genetic elements (MGEs). So when MGEs move between bacteria, the defences move with them, generating a fast turnover of defences in bacteria. But what about the antiviral defence turnover in the MGEs themselves? 🤔

🧵👇

02.03.2026 08:36 👍 75 🔁 45 💬 1 📌 3
Institut Pasteur hiring Chef d'Unité de recherche en virologie - IP Guinée H/F/X in Conakry Region, Guinea | LinkedIn Posted 4:38:22 PM. 🔬 L'Institut Pasteur de Guinée, membre du Pasteur Network, joue un rôle central en matière de…See this and similar jobs on LinkedIn.

Institut Pasteur of Guinea is looking for a head of virology www.linkedin.com/jobs/view/43...

03.03.2026 15:01 👍 1 🔁 0 💬 0 📌 0
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Improving the detection of #diphtheria toxin production by Corynebacterium diphtheriae and C. ulcerans, our latest work @pasteur.fr is out: www.biorxiv.org/content/10.6...

02.03.2026 06:41 👍 3 🔁 0 💬 0 📌 0
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A novel version of diphtOscan is available at gitlab.pasteur.fr/BEBP/diphtos.... v2.2.0 makes it easy to install on local computers. diphtOscan scans genomes and extracts information including #diphtheria toxin and antimicrobial resistance genes, biovar, species and subtyping information.

17.02.2026 12:51 👍 2 🔁 5 💬 0 📌 0
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03.02.2026 08:51 👍 177 🔁 56 💬 6 📌 1
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Wikipedia is needed now more than ever, 25 years on The online encyclopedia is an antidote to an increasingly poisoned information ecosystem. Researchers should help to nourish it.

I couldn’t agree more! Help support Wikipedia.
It has been a pillar of high-quality knowledge sharing since the early web, and it’s more relevant than ever in the fuzzy age of AI
www.nature.com/articles/d41...

30.01.2026 13:44 👍 6 🔁 3 💬 1 📌 0
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All Awards We challenge innovators around the world to work on urgent priorities in global health and development. We issue new challenges regularly and award the most promising proposals with grant funding.&nbs...

Outbreak of anti-#Klebsiella grants from @gatesfoundation.bsky.social @wellcometrust.bsky.social and novonordisk! gcgh.grandchallenges.org/grants/JTdCJ...

31.01.2026 07:29 👍 3 🔁 0 💬 0 📌 0
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Postdoctoral position - Synthetic Biology / Bacterial Immunity - Research The Bikard lab at Institut Pasteur in Paris is seeking to hire postdoctoral researchers. We are investigating bacteria / bacteriophages interactions, and the genetic innovation that happens at this in...

🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology and🛡️ Bacterial Immunity. Come do great science with us in the middle of Paris! 🇫🇷🥐 research.pasteur.fr/en/job/postd...

28.01.2026 11:19 👍 74 🔁 81 💬 0 📌 2

great update on #Klebsiella research!

28.01.2026 09:22 👍 1 🔁 1 💬 0 📌 0

3 weeks left to submit an abstract for the Klebsiella Seminar Series!
It is FREE, but registration is required.
#AMR #Microsky #UTIsky

sites.google.com/view/klebclu...

26.01.2026 14:01 👍 4 🔁 5 💬 0 📌 0
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Carbapenem resistant Klebsiella pneumoniae isolates at a tertiary hospital in Cape Town, South Africa, are dominated by specific local clones rather than previously described international lineages Author summary Carbapenem resistant K. pneumoniae (CRKP) have emerged as a cause of hospital and community acquired infections, posing a significant threat to public health, and have hence been listed...

First paper of this year is out now! 📢
Very happy to present work with my collaborators Andrew Whitelaw and Mae Newton-Foot and especially great work from PhD student Kedisaletse Moloto at Stellenbosch University: journals.plos.org/plospathogen...

20.01.2026 15:42 👍 9 🔁 6 💬 1 📌 0
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Dermatose nodulaire contagieuse en France: épidémiologie, microbiologie et contrôle: www.sfm-microbiologie.org/2026/01/16/e... @sfmicrobiologie.bsky.social @baptistedemey.bsky.social #LumpySkinDisease

20.01.2026 05:18 👍 1 🔁 1 💬 0 📌 0
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Deadline is approaching (Feb 9) to apply for a PI position at Institut Pasteur. Come join us and contribute to an amazing scientific environment!!!

19.01.2026 16:55 👍 17 🔁 31 💬 1 📌 0
Antimicrobial Resistance – Genomes, Big Data and Emerging Technologies — 20260323 Highlighting the importance of genomic data in the fight against AMR

Dear #AMR #genomics and big data community: please be informed that the programme of the Wellcome AMR conference in Hinxton on March 23-26th is now online: coursesandconferences.wellcomeconnectingscience.org/event/antimi... - please register before Feb 24th for onsite participation

14.01.2026 10:39 👍 7 🔁 7 💬 0 📌 1
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RFK, Jr.–Backed Lyme Disease Conspiracy Theory May Be Probed under New Bill President Donald Trump is expected to sign a defense bill this week that orders an investigation into whether the U.S. military bioengineered Lyme disease

Wasting money and resources to investigate a conspiracy theory about Lyme Disease, despite the known mechanism of how it infects humans.

🧪 www.scientificamerican.com/article/rfk-...

16.12.2025 20:44 👍 115 🔁 66 💬 12 📌 13
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By analysing 336 KpSC genomes from human, animal, and environmental sources, we reveal strong population compartmentalisation. Environmental sublineages (farms) are highly diverse and persistent, while human-associated strains (clinical and WWTP) show fast turnover and multidrug resistance profiles.

16.12.2025 11:59 👍 2 🔁 2 💬 1 📌 0

I’m really happy to share this work, which wouldn’t have been possible without the contributions of many, especially @sylvainbrisse.bsky.social and @crodrigues87.bsky.social from @pasteur.fr, and Elodie Barbier and Pascal Piveteau from @inrae-france.bsky.social.

16.12.2025 11:59 👍 3 🔁 1 💬 0 📌 0
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Seasons greetings from @pasteur.fr

15.12.2025 10:37 👍 3 🔁 0 💬 0 📌 0
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A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism and capacity for intra-species co-operation Why are there so many co-circulating Klebsiella pneumoniae clones? Using genomics and large-scale metabolic modelling of >7000 isolates, this study identifies structured, clone-specific metabolic spec...

Absolutely stoked to have this published in @plosbiology.org

We looked at the metabolism of #Klebsiella pneumoniae 🦠🧫. We not only demonstrated lineage-specific #metabolism, but that lineages can cross-feed and support each other.

journals.plos.org/plosbiology/...

#MicroSky #microbiology 🧬 🧪 💊

13.12.2025 09:45 👍 82 🔁 32 💬 4 📌 2
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Mid-career Group Leader position in AI in genomics at Institut Pasteur, Paris - Research Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...

Opening of a Group Leader position in AI in genomics at Institut Pasteur @pasteur.fr , Paris research.pasteur.fr/en/call/mid-...

06.12.2025 09:48 👍 9 🔁 14 💬 0 📌 0

📣🦠Check out our new Editor’s Spotlight! Senior MGEN editor Jesse Shapiro tells us about a recently published paper on the bystander effect on the evolution of Bordetella parapertussis, a non-target species of the pertussis vaccine #MGEN

Read the full blog here: microb.io/48zfOlJ

02.12.2025 13:01 👍 8 🔁 9 💬 0 📌 1
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The potential for large outbreaks of pertussis highlights the importance of maintaining or increasing vaccine coverage in pregnancy and in infants and children.

02.12.2025 06:24 👍 0 🔁 0 💬 0 📌 0
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Global Incidence of #Pertussis after the COVID-19 Pandemic - A large collaborative effort under the auspices of the International #Bordetella Society, led by Andrew Gorringe, from the UK Health Security Agency. jamanetwork.com/journals/jam...

02.12.2025 06:24 👍 5 🔁 3 💬 1 📌 0

And a big thanks to our funders @gatesfoundation.bsky.social @pasteur.fr @ibeidlabex.bsky.social @wellcometrust.bsky.social @klebnet.bsky.social

30.11.2025 19:51 👍 1 🔁 0 💬 0 📌 0
Bluesky

Thanks to @kjolley.bsky.social @chcrestani.bsky.social @kelwyres.bsky.social @margaretlam.bsky.social Martin Maiden @pubmlst.org @daanensen.bsky.social @katholt.bsky.social Federica Palma, Melanie Hennart and Alexis Criscuolo @giphy-ip.bsky.social and other co-authors

30.11.2025 19:51 👍 4 🔁 0 💬 1 📌 0

The wide adoption of cgMLST LIN code strain taxonomies has the potential to result in a universal approach for standardized bacterial genotyping that could greatly enhance microbial biodiversity studies, international genomic epidemiology and infectious disease surveillance

30.11.2025 19:51 👍 2 🔁 0 💬 1 📌 0
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Data confidentiality is an important barrier to rapid response to outbreaks. As LIN codes are sufficient to define strain identity across countries, they provide a solution for cross-border collaborative genomic surveillance investigations, without the need to share genomic sequences themselves

30.11.2025 19:51 👍 2 🔁 0 💬 1 📌 0