Zina Uckeley

Lenacapavir-induced capsid damage uncovers HIV-1 genomes emanating from nuclear speckles - The EMBO Journal Following cell entry, HIV-1 capsids enter the nucleus by passage through nuclear pores and reach nuclear speckles with subsequent uncoating of the reverse-transcribed genome and its integration into s...

New paper out!

How can we force HIV genomes out of their capsid shells and what can we learn about HIV biology doing so?

Hint: capsid inhibitors actively re-route nuclear HIV complexes, and expose genomes via intriguing structural effects!
open access:
link.springer.com/article/10.1...
read below

Hypoxia increases susceptibility of human intestinal epithelial cells to rotavirus infection through repression of interferon induction Intestinal epithelial cells (IECs) serve as both a physical barrier and a source of robust antiviral interferon (IFN) response. As such, they constitute the primary barrier that enteric viruses, su...

Excited to share our latest publication! We show that hypoxia suppresses interferon responses to rotavirus, resulting in increased viral burden in vitro. Congratulations to @sorinjacobs.bsky.social and all co-authors for this great work! @meganstanifer.bsky.social @boulantlab.bsky.social

Basal IFN-λ2/3 expression mediates tight junction formation in human epithelial cells
Megan Stanifer, @boulantlab.bsky.social and colleagues
www.embopress.org/doi/full/10....

Basal IFN-λ2/3 expression mediates tight junction formation in human epithelial cells | The EMBO Journal imageimageInterferons (IFNs) are expressed at basal levels in pathogen-free environments, but the underlying mechanisms and functions are only little understood. This study demonstrates that epithelia...

How does steady-state type III IFN signaling relate to barrier function? Find out here: www.embopress.org/doi/full/10.... Congratulations to Yağmur Keser and Camila Metz-Zumaran for this amazing and comprehensive study! @boulantlab.bsky.social @meganstanifer.bsky.social

We’re back with another season of monthly seminars bringing together diverse and leading investigators worldwide to share cutting-edge arbovirus science.
🧬 Topics span molecular virology, virus–vector interactions, epidemiology, pathogenesis, and more.
📅 3rd Thursday each month
🕚 11 AM US ET Zoom

Gruppenfoto der Gründungsmitglieder des Verbands Deutscher Infektionsforscherinnen - Infect-Net. Acht lächelnde Frauen stehen um ein Werbebanner des Frauennetzwerks Infect-Net. Eine Frau hält die unterschriebene Satzung in die Kamera. Foto: Kathrin Czoppelt.

🥂 Ein Grund zu Feiern: Wir haben den Verband Deutscher Infektionsforscherinnen gegründet! 👩‍🔬🦠🥳
Am 25. März 2025 haben wir in München einen Verein gegründet, um die Ziele und die Mission von #InfectNet langfristig weiterzuführen und weiterzuentwickeln. 💜 #megastolz
👉 www.infectnet.org/web/blog-pos...

Diagram showing how UFL1 interacts with flaviviral NS2A, Capsid, and NS3 proteins to promote viral assembly.

Excited to share our new paper led by recent PhD, Dr. Hannah Schmidt! We found that UFMylation unexpectedly promotes flavivirus particle production by specifically regulating viral assembly. Check it out! #virology #UFMylation #flaviviruses
journals.asm.org/doi/10.1128/...

Interested in #trafficking in polarized cells? a post doc Position is available in @boulantlab.bsky.social lab in sunny Florida to work on a joint NSF-DFG project with us in Berlin! Steeve also has a 2nd position on gut hypoxia and viral immunity! please spread the word and repost!

Exciting news! We have two postdoc positions opened in our lab @UF! Study gut hypoxia & virus immunity OR immunity and intracellular trafficking in polarized cells. Come do cool science with a fun team! Check out all details: boulantlab.com/opportunities #PostdocJobs #ScienceTwitter

It's finally time for some #bunyavirales and #tick borne viruses with Ben Brennan from @cvrinfo.bsky.social and his much anticipated talk, this THURSDAY 17th. All welcome! Please help us with a re-post. 🕷️🦠🧫

Hi everyone, what's up? We have our monthly seminar this week, with some super cool work on arbovirus entry receptors from leading researcher Jolanda Smit from @unigroningen.bsky.social
All welcome - help spread the news with a re-post 🙂
NOTE THE EARLIER TIME for everyone outside the USA

Antibodies targeting Crimean-Congo hemorrhagic fever virus GP38 limit vascular leak and viral spread Glycoprotein GP38-specific antibodies reduce viral dissemination and GP38-mediated vascular leak in Crimean-Congo hemorrhagic fever virus infection.

Happy to finally see this study published, a great collaboration between academic, government and industry labs! We show that CCHFV GP38 can induce vascular leak and that this can be prevented by protective but not virus-neutralizing antibodies! www.science.org/doi/10.1126/...

Trump attackiert Infektionsforschung: Folgen für die globale Pandemieprävention

US-Präsident Trump kürzt massiv Fördergelder für die Wissenschaft in den USA. Das hat auch direkte Auswirkungen auf die virologische Forschung in Europa und Deutschland und könnte die Pandemieforschung vor große Probleme stellen. Mehr dazu im Deutschlandfunk: www.deutschlandfunk.de/stand-up-for...

ASV 2025 | American Society for Virology The website for the 44th Annual Meeting of the American Society for Virology.

Are you ready for #ASV2025? Check out the schedule at a glance and more information on our webpage.
asv.org/asv2025/

#LoveVirology

And that was that – the 34th annual virology meeting ended today, with awards and an outlook on the meeting next year in Heidelberg. We at the GfV are very grateful to the local organizing team from @leibnizliv.bsky.social, the many many helpers as well as catering and Conventus!

It’s a wrap.. I had a fantastic time at #GfV2025 discussing cool science and connecting with inspiring colleagues! Thanks for the opportunity to present our work on how hypoxia affects rotavirus infection and all the inspiring questions. @gesvirologie.bsky.social

Great talk from @zinauckeley.bsky.social at the German society of virology #GfV2025
How hypoxia in the gut impacts rotavirus infection. Great feedbacks from the attendees! Great meeting as usual!

Our undergrad Victoria explains her project! Fantastic work 💪

NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts Nature Communications - Bunyaviruses are a large group of viruses that infect a wide range of organisms, including insects, animals, plants, and single-celled organisms. Here, Terhzaz et al show...

Cool new research explaining the role of NSm during bunyavirus infection of mosquitoes.
rdcu.be/d8Slv

Opportunities for CSV trainees! Apply for the CSV Lab Exchange Program to fund research collaborations or training—deadline: April 1. Details: www.csv-scv.ca/en/lab-excha...
Submit your abstract by March 1 to present at the CSV virtual seminar on April 11: forms.gle/zw2YdxQ2kLcc...

Schematic showing the experimental outline for a full genome arrayed CRISPR screen. 384-well plates containing cells with an arrayed crRNA library are infected with Cryptosporidium parasites, which undergo asexual rounds of replication intracellularly, followed by sexual development to male and female forms. Plates are then fixed and immunolabeled to detect all parasites, female parasites, host actin recruited to parasite vacuoles, and host nuclei. Three z-stacks were imaged by high content microscopy to detect apically located parasites as well as host cell actin and nuclei.

Have you ever wondered how knocking out every single gene in the human genome, one by one, might affect your intracellular pathogen of interest? We did, & boy was it a wild ride! Happy to share our preprint discovering the essential host genome for Cryptosporidium -

www.biorxiv.org/content/10.1...

Abstract Submission | American Society for Virology Abstract submission for the ASV 2025 annual meeting July 14-17, 2025, in Montreal, Quebec, Canada. Hosted by McGill University.

The ASV 2025 abstract deadline is in less than one week! Monday, February 3, 2025 (11:59 pm./23:59 Eastern time)
asv.org/asv2025/abst...
#ASV2025 #LoveVirology

🚀 We are looking for a Junior Research Group Lead as part of the Helmholtz Initiative with 2 to 6 years of academic experience 🌟
👉 Application process:
You apply by 15.02.25. One candidate per institute will prepare a full proposal by 30.04.25.
📄 More: one2.vs12951.internet1.de/sites/defaul...

The American Society for Microbiology (ASM), one of the largest life sciences societies, is partnering with the GfV to advance virology research and global collaboration.

You can find more information here: asm.org/Press-Releas... (IVC)

Fresh out of the press! ✨Check out our new paper on the violent entry of the HIV capsid into the nuclear pore — and how it cracks the gate! 🤯 💥 Incredible work from @becklab.bsky.social and @hummerlab.bsky.social 🤩 More here: www.biophys.mpg.de/2842024/hivcapsid-cracks-the-npc?c=2011019 🔗 #teamTOMO

We are very excited that our in-situ structural analysis of the Ebola virus nucleocapsid assembly cascade is now published in @cellpress.bsky.social!

Physical Virology: across length scales Our preparedness against viral diseases and our ability to exploit viral structures to advance technology, both require multidisciplinary collaborations. In this context, physics-oriented approaches …

Registration is open for the EMBO|FEBS Lecture Course Physical Virology: across length scales #EMBOPhysicalVirology organized by Marta Bally, Pedro de Pablo, Susan Daniel & Ekaterina Selivanovitch 🦠🔬💻🧪

Sign up and share! meetings.embo.org/event/25-phy...

Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region - Nature Medicine Genomic and epidemiologic analyses revealed that a novel reassortant viral lineage of the Oropouche virus, which has been circulating in the western Amazon region of Brazil for about a decade, is asso...

Take climate change, deforestation,
a #mosquito-borne #arbovirus with the ability to exchange RNA genomic segments, and here you go

ScienceAdviser: Of all the breakthroughs in 2024, what topped Science’s list? Today in Science and science: Science’s breakthroughs—and breakdowns—of the year, from a game-changing drug to lessons not learned

What is your breakthroughs & breakdowns?

Here are Science’s breakthroughs—and breakdowns—of the year

www.science.org/content/arti...

🚨Deadline extended!🚨

We are making it even easier to play an active part in the Virology meeting 2025, by giving you extra time to submit your abstracts!

ℹ️ Submission will now be possible until 8 December!
🖱️ virology-meeting.de/registration...

#GfV2025 #virology #virologymeeting #virus #viruses