Marc-André Legault

Share link: authors.elsevier.com/a/1l5tbgeXDy-p

We apply our estimator to study the effect of a reduction in circulating sclerostin levels to predict the safety and efficacy of romosozumab. We also estimate the effect of a reduction in LDL-c and waist-to-hip ratio on cardiovascular outcomes.

In realistic MR simulations, we find that our estimator is competitive with other semi- and non-parametric methods. We also identify instances where violations of statistical assumptions lead to substantial bias in MR estimates that can be avoided with Quantile IV.

A flexible machine learning Mendelian randomization estimator applied to predict the safety and efficacy of sclerostin inhibition Mendelian randomization (MR) enables the estimation of causal effects while controlling for unmeasured confounding factors, but MR estimators often rely on strong parametric assumptions. We propose an...

My main postdoc project is now published in @AJHG! We describe a MR estimator (Quantile IV) that does not rely on parametric assumptions and allows for heterogeneous causal effects. www.cell.com/ajhg/abstrac...

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to ML.Antibiotics@gmail.com. See
lnkd.in/dVVk4N3s. #microsky

Join us at UdeM and CHU Sainte-Justine! The bioinformatics community at Sainte-Justine is growing, and our clinician colleagues are really great.

Plasma proteome variation and its genetic determinants in children and adolescents - Nature Genetics This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.

Out today in Nature Genetics: Using MS-based proteomics, we mapped 1,200+ plasma proteins in 2,100+ children, showing how genetics & development shape blood protein levels during childhood.
nature.com/articles/s41588-025-02089-2
#PediatricProteomics #pQTL
First author @liliniu.bsky.social explains ⬇️

Pitfalls in performing genome-wide association studies on ratio traits Any variant associated with either numerator or denominator will associate with the ratio in GWAS of sufficient size. Associations with ratio traits are thus not specific to the ratio. Instead, we rec...

Excited to share a new paper from @insitro.bsky.social (first author @zmccaw.bsky.social ) in @hggadvances.bsky.social vances.bsky.social on scrutinizing the practice of using a ratio trait (numerator / denominator) for GWAS.

www.cell.com/hgg-advances...

I used to put our open-source software on business card-sized CD ROMs & pass them out at conferences. We had code, sample data, & PDFs on the disk.

IGES: the International Genetic Epidemiology Society

Dear early career genetic epidemiologists:

The IGES Young Investigator Committee is looking for new members! It's a fun group, low time commitment, and great way to network with peers while supporting trainees around the world.

Apply here by Dec 31st:
www.geneticepi.org/yic_position...

🚨NEW PREPRINT!
Interested in Mendelian randomization and proteomics? 🧬

We created a comprehensive multi-ancestry proteome-phenome-wide atlas of protein-disease associations in European, African, and East Asian ancestries!

Preprint: www.medrxiv.org/content/10.1...

Website: broad.io/protein_mr_a...