We are excited to announce a new Post-doc position! 🚨
This project will be based at Swansea University, under the supervision of Dr Emma Kenyon, and will explore the structure and function of the cupulae of the lateral line neuromasts in zebrafish.
More details:
www.swansea.ac.uk/jobs-at-swan...
Today's (long overdue) paper spotlight actually comes from us! This review is a great place to start if you want to understand spontaneous activity in the cochlea! Definitely worth a read, even if it's just to look at the cute cartoons :)
The paper: pubmed.ncbi.nlm.nih.gov/41731255/
At Sheffield, our research focuses on uncovering mechanisms behind hearing disorders and restoring auditory function. The Hearing Research Group unites experts in physiology, genetics, developmental and stem cell biology, and neuroscience to tackle deafness and age-related hearing loss.🧪👂
Around 90 million children and adolescents live with hearing loss. Globally, 1.5 billion people are affected, including 430 million with disabling hearing loss. Without action, this could rise to 2.5 billion by 2050.(www.who.int, World Report on Hearing 2021)
Today is #WorldHearingDay! 👂
This year's topic focuses on hearing loss in school-age children, and highlights the difficulties in diagnosing hearing loss at such an early age especially in regions with low resources.👨👩👧👧
www.who.int/campaigns/wo...
#Neuroskyence #HearingResearch
Happy #MicroscopyMonday everyone!🔬 Today's image comes from Ivy and it shows a beautiful dissection of the organ of Corti of a mouse!😮🐁
In the image the 💚 signals are myosin VI, an essential protein expressed in auditory hair cells for hearing acquisition!👂✨🧪
#Neuroskyence #HearingResearch
Happy #MicroscopyMonday everyone!🔬🤩 Today's image is a stunning one and comes from Zoë! In this image we can see both the inner and outer hair cells stained with Phalloidin (in ❤️) whereas the supporting cells are outlined with Cx30 and Cx26 (respectively in 💚 and 💜)🐁
#Neuroskyence #HearingResearch
Last week in beautiful Puerto Rico🌞, our amazing PIs Ginny and Adam presented their work at the ARO conference👂, soaking up inspiring talks and posters, trading the UK freeze🥶 for sunshine😎 while sharing science and learning from others. 🧪
#ARO #HearingResearch #Neuroskyence
This week's #MicroscopyMonday is the second part of a previous one!🔬👀 Two weeks ago we showed you a view of the synapses of a 3 day old mouse and today we are showing you how it changes over time with this beautiful image of a 12 day old mouse coming from Char! 🧪🐁
#Neuroskyence #HearingResearch
Happy #MicroscopyMonday everyone!🧪🔬Today's image comes from Sarah and it shows the hair cells (highlighted by Myo7a in red) and the spiral ganglion neurons (highlighted by Beta tubulin in blue) in a two month old mouse cochlea!🐁👂
#NeuroSkyence #HearingResearch
Happy #MicroscopyMonday everyone! 🔬To celebrate February we have a beautiful image from Char and shows a stunning view of the synapses of the inner hair cells in a 3-day-old mouse.🐁👂In this snapshot CtBP2, in red, labels the presynaptic ribbons and PSD95, in green, labels the postsynaptic sites.✨🧪
Happy #MicroscopyMonday everyone!🔬🤩Today's image is something a little bit different, it comes from Andrea and shows a phalloidin staining of the inner ear of a 30 hours old zebrafish with the first hair cells already present (highlighted by the arrows) and growing!🐟🧪
#NeuroSkyence #HearingResearch
New Year, but same old happy #MicroscopyMonday everyone! 🎆We kick off 2026 with a beautiful image from Char showing the apex dissected from a 34 day old mouse cochlea.🐁 Beta III tubulin (in green) shows the spiral ganglion neurons in the center and their afferent fibres!🧪🔬
#NeuroSkyence
📢Howdy all, just two weeks until the deadline of this PhD opportunity within the hearing group! Please share around as much as possible. This exciting project within the Carlton lab would be a great fit for someone interested in sensory neuroscience!👂🧠
www.findaphd.com/phds/project...
Christmas is near and we would like to wish all of you happy holidays from everyone at the Hearing Research Group!🎄🎆👂
We wanted to say a big congratulations to our very own Scot, Dr. Charlie Cranston! Big congratulations for passing your viva this week! We can't wait to see what the future holds for you and we know it will be bright! Good job Dr. Cranston!🎉🎊👏🎆
Happy #MicroscopyMonday everyone! 🔬Today's image is from Char and shows a super-resolution Airyscan view of the synapses of the inner hair cells in a 34-day-old mouse.🐁👂In this snapshot CtBP2, in red, labels the presynaptic ribbons and PSD95, in green, labels the postsynaptic sites.✨🧪
#NeuroSkyence
Happy #MicroscopyMonday everyone!🔬 Today's image comes from Alice and it's a great fluorescent image of inner hair cells (stained with Phalloidin, magenta) from a 2-months old mutant.🐁 In this photo the expression of Baiap2l2 (green) was successfully restored with AAV-gene therapy.💉🧪
#NeuroSkyence
💚 🏆 We’re very happy to have received the Sustainability Lab Leaf Silver Award for creating an even greener, more sustainable research environment! 🧪 🥬 Many many thanks to everyone in the lab for their efforts #Sustainability #GreenLabs #SheffieldHearingGroup
Rinta Mathew: Postdoc
Research: Investigating regulation of signal processing in developing and ageing mouse cochlea in vivo and how these influence central auditory neuronal pathways.
Method: 2-photon imaging & AAV-gene delivery
Twitter: x.com/MathewRinta
Lab snack: Nature Valley Peanut & Chocolate
Happy #MicroscopyMonday everyone! 🌟🔬 Here’s an image from Ivy of outer hair cells (OHCs) and inner hair cells (IHCs) from a P20 mouse.. 🐁✨#Microscopy #HearingResearch #Cochlea #Neuroscience #Neuroskyence
🌿🏅 We’re proud to announce the Sheffield Hearing Group has been awarded the Sustainability Lab Leaf Bronze Award for creating a greener, more sustainable research environment! 🌎🔬Huge thanks to everyone in the lab for their efforts🌱👏 #Sustainability #GreenLabs #SheffieldHearingGroup
Howdy all, today's spotlight comes from Saman Hussain and was published in September. This (very pretty) paper identifies spontaneous calcium activity within the sound-detecting stereocilia driven by the MET channel, and independent from the usual calcium waves!
pmc.ncbi.nlm.nih.gov/articles/PMC...
Happy #MicroscopyMonday everyone!🔬🌟Nic has taken a cross-section image of the retina under the microscope: red shows the Retinal Pigment Epithelial cells, orange shows photoreceptor cell bodies with cilia & green shows the outer nuclear layer with just photoreceptor cell bodies 👁️✨
#neuroskyence
📢Howdy all, I'm excited to announce a new PhD opening within the Carlton lab in the hearing research group! This project will use primarily electrophysiology to investigate how noise influences feedback to the cochlea from the brainstem! More details can be found at:
www.findaphd.com/phds/project...
Lillian Smith | PhD student
Research focus: Understanding the mechanisms associated with mitochondria dysfunction underpinning ARHL and neurodegenerative diseases using in vivo physiology, 2-photon functional imaging, RNA sequencing, and immunolabeling
Fun fact: My go-to lab snack is mini cheddars
Happy #MicroscopyMonday everyone!🌟🔬 Today's photo comes from Alice showing an scanning electron microscopy image of outer hair cells lacking many stereocilia due to abnormal expression of a protein important for hair bundle maintenance! 🧪🐁
Last week we said goodbye and good luck to Francesca, who’s been an amazing part of the Sheffield Hearing Group! Thank you, Fran, for everything — the lab won’t be the same without you! 🧪🌟
Howdy all. Recently one of our PIs (Adam) appeared on The Naked Scientists podcast to discuss hearing loss and tinnitus! The free full recording can be found on their website at: www.thenakedscientists.com/podcasts/nak...
Worth a listen if you're interested in hearing!
Happy #MicroscopyMonday everyone!🌟🔬 Today's photo comes from Zoë and shows the inner and outer hair cells in the organ of Corti of a mouse stained with Phalloidin (in red), the supporting cells outlined with connexin 30 (in green), and the cell nuclei stained with DAPI (in blue).🧪🐁
