@maxfus
Asst. Prof. Uni Groningen 🇳🇱 Comp & Exp Biochemist, Protein Engineer, 'Would-be designer' (F. Arnold) | SynBio | HT Screens & Selections | Nucleic Acid Enzymes | Biocatalysis | Rstats & Datavis https://www.fuerstlab.com https://orcid.org/0000-0001-7720-9
BREAKING: For the first time in 35 years the Ig Nobel ceremony will move to Europe. "There are no immediate plans to return the ceremony to the US."
www.theguardian.com/science/2026...
Food for thought for conference steering committees.
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guess they're just too busy playing the other game
Finding one mutation that improves a protein is hard. Finding five that work together is exponentially harder.
Today in @science.org, Hsu and Konermann labs present MULTI-evolve, a lab-in-the-loop framework that does it in just one machine learning-guided round.
Did you go through the issues on GitHub already? This was a recurrent complaint and I think some may have provided files / details
Stupid name for a social network anyway.
Hey great paper by the way 😊
Right, i thought you meant there creation.
Ok reading indeed is a bit annoying and worse so in those with many replies. But at least @bsky.app is still improving and developing, and usually toward the better. Think we'll see this one improve.
Anyway, not sth that kills overall experience for me
:)
I meant the creation of BlueSky threads that OP didn't like
what's the problem with threads?
So hyped seeing this beautiful work from my former lab being published. 45 bases of RNA that replicate itself! The cutest ribozyme you'll have ever seen
@edogia.bsky.social the world lusts a bluetorial!
Five years after the rollout of Covid-19 vaccines started, it seems the mystery of why the Astra-Zeneca and J&J vaccines led to a rare but deadly side effect of unusual blood clots and bleeding has finally been solved.
It's a fascinating case of molecular mimicry that may help make vaccine safer.🧪
I made a map of 3.4 million Bluesky users - see if you can find yourself!
bluesky-map.theo.io
I've seen some similar projects, but IMO this seems to better capture some of the fine-grained detail
I wish base line integrity were a factor we could factor in as a given, but fear that's not the world we live in. And it's not even bad faith actors alone, opportunity makes the thief and besides, if everyone else is using AI except you, what do you do
I really think we're at a tipping point. AI is radically entering all of society & certain systems cannot cope, including a lot of the scientific process. I predict current grant & paper writing & review systems are going to break this year, but as adaptation will take longer, we'll see a lot of 😡
They had 3x as many applications as last year. Trump meets the LLM effect, will be the same for ERCs
This year's MSCA call was brutal. My stellar postdoc got 96.4 and was below cutoff. For chemistry it seems cutoff was 97.6, with 96.6 for the reserve list. This was their 3rd time applying, year 1 87, Year 2 93, this year 96.4. Each year the bar moved. At those cutoffs, peer review is meaningless.
The village model isn't really in place in much of the western world anymore, whether that prevents successes is open for debate
On topic, at least anthropic has someone (who seems actually nice) dedicated to ethics, guess how many Grok has
Must admit I love it
First-time posters need to be endorsed by an established arXiv author in their own field.
The new rule is mostly to try and discourage people from trying to get something started by sending some rubbish to arXiv.
🦠🧪
www.science.org/content/arti...
seeing that even claude code consistently doesn't get git commands right the first time round makes me feel much less stupid
My time in @martinsteinegger.bsky.social's group is ending, but I’m staying in Korea to build a lab at Sungkyunkwan University School of Medicine. If you or someone you know is interested in molecular machine learning and open-source bioinformatics, please reach out. I am hiring!
mirdita.org
Two panel graphic showing new method for tracking gene activity.
The barrel-shaped structures found by the thousands in most animal cells are one of biology’s biggest mysteries. But although researchers haven’t figured out the function of these “vaults,” they now report a new use for the puzzling particles.
Learn more: https://scim.ag/49pv8mB
New preprint!
Led by @sarahgersing.bsky.social we map how 7,500+ variants in glucokinase (GCK) affect binding to GKRP and disentangle this from stability.
We now have activity, abundance, and interaction scores for 7,128 GCK variants - a resource for understanding phenotypes and glucose homeostasis.
Sadly, here in Europe, one advise to ECRs is to, whatever action you decide to take, think very hard before posting about it on social media, because, you know, you may want to go to a GRC at some point. Is this hypocritical or just survival mode?
Want to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version?
I made an app you might like: adamkucharski.github.io/pdf2plot/
It all started a few years ago... 🧵
with MD, with AI MDemulators, with AF hacks, ...
Thanks for sharing. Not surprised but good to see data also for antibodies that squares really well with our analysis on protein design more generally
bsky.app/profile/maxf...
Exactly
The only format worse than pdb is cif
