Sam B

I've maintained for some time that Joe Rogan is the idiot's thinking man.

From the Psychonaut community on Reddit Explore this post and more from the Psychonaut community

Wendy Tucker (daughter of Ann Shulgin) and Paul Daley (longtime collaborator of Sasha Shulgin) are currently doing an AMA on Reddit for those interested

www.reddit.com/r/Psychonaut...

🤯

Some beautiful mathematics and physics! Thanks for sharing @arenamontanus.bsky.social :)

̶1̶.̶ ̶A̶l̶e̶x̶a̶n̶d̶e̶r̶ ̶S̶h̶u̶l̶g̶i̶n̶
̶2̶.̶ ̶A̶n̶t̶h̶o̶n̶y̶ ̶B̶o̶u̶r̶d̶a̶i̶n̶
̶3̶.̶ ̶D̶a̶v̶i̶d̶ ̶L̶y̶n̶c̶h̶

Protein vapes

Ha! I'm reading it right now, and this is what directly prompted the post. Was hoping nobody else realized and I somehow missed other biographies ;)

Top 5 Isaacson biography wishlist:

1. Alexander Shulgin
2. Robert Anton Wilson
3. John Lilly
4. Buckminster Fuller
5. Aleister Crowley

Helping @michaelpollan.bsky.social understand the difference between millennial and Gen Z readers in one screenshot

Hip-hop producer Madlib’s home and record collection destroyed in LA fires Influential musician confirms loss of extensive record collection amassed over 30 years

😭😭😭😭😭

www.theguardian.com/us-news/2025...

Stay safe out there, Andrew!

5-HT2A SNPs Alter the Pharmacological Signaling of Potentially Therapeutic Psychedelics Serotonin (5-hydroxytryptamine; 5-HT) 2A receptor (5-HT2AR) signaling is essential for the actions of classical psychedelic drugs. In this study, we examined whether sequence variations in the 5-HT2AR gene affect the signaling of four commonly used psychedelic drugs. We examined the in vitro pharmacology of seven non-synonymous single-nucleotide polymorphisms (SNPs), which give rise to Ser12Asn, Thr25Asn, Asp48Asn, Ile197Val4.47, Ala230Thr, Ala447Val, and His452Tyr variant 5-HT2A serotonin receptors. We found that these non-synonymous SNPs exert statistically significant, although modest, effects on the efficacy and potency of four therapeutically relevant psychedelics. Significantly, the in vitro pharmacological effects of the SNP drug actions at 5-HT2AR are drug specific.

Has anyone looked at the effects of A242S substitution (rodent to human) on the potency and/or efficacy classical psychedelics (LSD, DOI, psilocin) at the corresponding 5-HT2A receptors?

Bryan Roth's paper on human SNPs doesn't cover species diff unfortunately...

pubs.acs.org/doi/10.1021/...

This is awesome @alexkwan.bsky.social ! 🥳🥳

Stumbled upon that place the first time I visited Lisbon and was very pleasantly surprised.

The hospital themed bar out back has a great view!

Is this tracer suitable for receptor occupancy studies with other 5-HT2A agonists?

The most technically far-reaching and interesting (accidental) conversation I've ever had...

Serendipitously seated between @arenamontanus.bsky.social & Forrest Landry at the Lionheart Ventures Summit 2023 (in)formal dinner.

More relevant as I re-read Bostrom's Superintelligence a decade later...