Christine Mordstein

codon usage About the Conference Codon usage bias—the preference for certain synonymous codons—is a key factor in genome regulation. Codon usage and synonymous codon mutations have been shown to influence gene ex...

Just a reminder - Please Register for the 3rd Codon Usage Conference in Montreal, Canada from May 31- June 3, right after the RNA Society Meeting.

Even if you can't go, please share! #RNA #RNAsky #RNAbiology

sites.google.com/view/codonus...

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...

🚀 Just published: New1 shields mRNAs from no-go decay — by preventing ribosome crashes at specific codons.
What’s new?
New1 (eEF3 homolog) stops ribosomes from stalling at C-terminal AAA/AGG/CGU codons. No New1 = collisions + Hel2 recruitment + Cue2-mediated no-go decay.

RNA in physiology and disease | Genetics Society Meeting background RNA molecules are at the heart of normal physiological processes, and their dysregulation can drive a wide range of human diseases. This international meeting will bring together wo...

Have a look at this fantastic meeting and save the date!

The “RNA in Physiology and Disease” conference, hosted by @gensocuk.bsky.social, will take place 7–9 September 2026 in Newcastle, UK.

genetics.org.uk/events/rna-i...

I don't understand where science in the UK is currently heading. It's heart-breaking.

With luck, I'll be at the hotel around 3.30pm, just in time for a bunch of calls that I have to take..😂 I'll see you at the poster session

Loving the usual UK public transport efficiency. So far, I have had only 2 trains cancelled that I was travelling on. I might be lucky and arrive only 2.5h delayed 🤔

En route to #RNAUK2026 in beautiful Windermere! This is still by far my favourite conference series and I'm excited to see many old friends and former colleagues again.

I have a poster too, so come say hi if you are there and curious about the work we do at Centillion 👉 P50

#RNAsky #RNArocks

Discuss #RNA 3' ends and their regulation at the EMBO Workshop "RNA 3' ends and beyond" in #Oxford, United Kingdom, 7–11 September 2026.

Deadline: 4 May 2026

https://meetings.embo.org/event/26-rna3
#EMBORNA3EndsBeyond #RNAsky #LifeSciences #meeting #EMBOevents 🧪

Congratulations Sara & Jeroen et al! 👏 Hope to see you at RNA UK?

Double stranded RNA sensing is silenced during early embryonic development Nature Communications - The type I interferon response is suppressed during early development, making embryos susceptible to pathogens. Here, the authors show that this suppression contributes to...

Happy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5.
Thanks to all collaborators, we could not have done it without you 🤩

rdcu.be/eWMfA

‘She has no expertise’: the US medical community girds for Tracy Beth Høeg’s tenure at the FDA The Danish American who doubted Covid shots is meant to lead drug regulation – but has focused on vaccines

New director of FDA Center for Drug Evaluation and Research has "no expertise...no apparent experience in drug development, regulation or management..doesn’t seem to have any of the qualifications for running the drug-regulation department" www.theguardian.com/us-news/2025...

Check out the latest paper from the Gonatopoulos-Pournatzis lab using CRASP-seq, an RNA-coupled #CRISPR screening platform, to uncover novel #splicing regulators.

a close up of a green and white sponge with purple spots Alt: A green and white sea sheep grazes on a green lawn of algae on a surface underwater.

This is the "SEA SHEEP" (Costasiella kuroshimae) & it took the old axiom: "you are what you eat" VERY literally.

It eats algae & rather than just digest them, it harvests the chloroplasts & becomes PHOTOSYNTHETIC. Solar slug!

Also, some of its cousins can rip their own heads off.

Figure S7 with panels A through UU

Wow this is a seriously serious supplementary figure from @cellpress.bsky.social today. Panels A through UU.

I get that Cell likes to minimize the number of supplementary figures. But is this really what is happening here?

www.cell.com/cell/fulltex...

#RNAsky

How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)

Can we please stop calling it "translational efficiency" because it isn't. It is a measure of ribosome association.

THANK YOU.

This!!

👇 Fantastic line-up! #RNAsky

Great selection, well done! 👏

Compact RNA sensors for increasingly complex functions of multiple inputs - Nature Chemistry Designing single molecules capable of complex sensing functions is challenging. Now, using crowdsourced RNA designs from the online game Eterna, compact single-molecule sensors have been demonstrated ...

@eternagame got single RNAs to compute functions like all logic gates, A>B, and A*B/C^2, relevant for tuberculosis detection! Now looking for partners to scale to complex applications. Collab w/ Greenleaf Khatri labs @christianchoe.bsky.social @stanfordmedicine.bsky.social at
doi.org/10.1038/s415...

#RNASky

Ok. I'm hoping to be there again 👍

I still don't see any speakers unfortunately!

I highly recommend this meeting! 👌 #RNAsky

Oxidative stress sensing by the translation elongation machinery promotes production of detoxifying selenoproteins Selenocysteine, incorporated into polypeptides at recoded termination codons, plays an essential role in redox biology. Using GPX1 and GPX4, selenoenzymes that mitigate oxidative stress, as reporters,...

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

Cool! Congrats!

Two group leader positions available in the broader areas of RNA science, RNA technologies, and RNA medicine. Attractive packages and a great environment. Come and join us at Helmholtz RNA Würzburg, Bavaria.

Hi Mark,
Picking up on this a bit now. I was wondering whether you also offer any DRS or cDNA sequencing support at all? I'm looking for the possibility for outsourcing this for our US site.