eBioMedicine – The Lancet Discovery Science

These threads—diagnostics, mechanistic science, emerging therapies, and lived experience—are finally beginning to connect. A more coordinated future for rare disease care is taking shape.
Full version here: www.linkedin.com/feed/update/...

🔬 Genomics is shortening diagnostic delays
🧬 IPSCs, organoids & CRISPR are transforming mechanistic insight
💊 Nucleic‑acid therapeutics are moving from isolated N=1 efforts toward more coordinated national approaches
🧡 Patients and families are essential partners shaping priorities and outcomes

🌍 Ahead of #RareDiseaseDay, reflections from the 5th @crick.ac.uk Rare Disease Conference: although each rare condition affects few people, 300M+ individuals worldwide live with a rare disease. Delayed diagnosis, limited treatments, and fragmented care remain major challenges.

Eoin Kelleher on sleep and chronic pain across the lifespan

🎧 Listen wherever you get your podcasts: open.spotify.com/show/37oRXtY...
📑Read the reviews:
Sleep apnea, heart health and testosterone: www.thelancet.com/journals/EBI...
Why sleep matters in chronic pain: www.thelancet.com/journals/EBI...

🥱😴 Sleep matters: a new eBioMedicine series on sleep health unveils how sleep, cardiometabolic health, hormones, and pain intersect across the lifespan. The 2 open-access reviews highlight mechanisms, clinical implications, and opportunities for integrated care.

Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion MACS represents a metabolic continuum between NFAT and adrenal CS. Increased activity of the adrenal enzyme 11β-hydroxylase (CYP11B1), which catalyses key steps in cortisol and 11-oxygenated androgen ...

Published in @ebiomedicine.bsky.social

Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion www.thelancet.com/journals/ebi...
non-functioning #adrenal #tumours
#Cushing's syndrome
#OpenAccess

#MedSky #EndoSky

⏳ As interest in ageing clocks grows, we examine what it will take to move these tools from curiosity to credible clinical biomarkers—highlighting advances in epigenetic clocks, key methodological gaps, and the path toward rigorous validation and clinical integration.

#AgeingResearch #Epigenetics

🚨 The February 2026 issue of eBioMedicine is now live.

This month’s Editorial tackles a central question in longevity science and modern medicine:

Can biological age be measured in a way that meaningfully improves clinical care?

🔗 All open access content here: www.thelancet.com/issue/S2352-...

End-to-end translation in neuroscience The British Neuroscience Association (BNA) Festive Symposium 2025, held on December 9, 2025, set out to examine what it really means for neuroscience to reach society. Rather than focussing on discove...

People are living with disease while waiting for research to become care. The @britishneuro.bsky.social Festive Symposium highlighted that the ethical duty of translational neuroscience now extends beyond discovery itself. Delivery is part of the science.

🔗 www.thelancet.com/journals/ebi...

Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion Benign adrenal tumours, found in 1–7% of adults, can be non-functioning (NFAT) or show mild autonomous cortisol secretion (MACS), i.e., biochemical co…

🧪 Publication in @ebiomedicine.bsky.social, project led by @wiebkearlt.bsky.social @mrc-lms.bsky.social & A Prete @unibirmingham.bsky.social with important contributions from @rug.nl theses by @ariadnaalbors.bsky.social , E van den Brandhof, Y Zhang & L Visser

www.sciencedirect.com/science/arti...

Hantavirus: Immune response after Puumala virus infection investigated More about the possible basis for therapy and vaccine!

🦠 #Hantavirus - How long does the immunity last after a Puumala #virus infection?

#MedUniVienna & @medunigraz.at​ investigated the immune responses elicited in Styrian Puumala virus patients.

📰 @ebiomedicine.bsky.social​

Great overview of where the field stands on henipavirus host-pathogen interactions, and the experimental models helping us study them 🧬🔬 Well done @carroll-lab.bsky.social and team👏
Worth a read 👇

🔍 On the cover
✍️ Editorial: Expanding intrathecal gene therapy for lysosomal storage diseases
🚨 First-in-human: High-dose AAV9 intrathecal gene therapy for paediatric CLN7
🧬 Research: Spatial transcriptomics links lipid metabolism to immune–stromal crosstalk in Sjögren’s disease

eBioMedicine January 2026 cover. The cover depicts scientists on ladders and scaffolds working on a strand of DNA.

📢 Our first issue of 2026 is now live! The latest issue highlights cutting-edge research in gene therapy, immunology, neuroscience, and translational medicine.

🔗 Read the full issue online

Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescents @dream-diabetes.bsky.social @ebiomedicine.bsky.social www.thelancet.com/journals/ebi...

Human lymph node, cross-section, artwork. Image copyright PIXOLOGICSTUDIO – Getty Images

A new study shows the immune system’s first responders—CD4+ Tfh cells—rapidly activate in draining lymph nodes to drive strong flu vaccine protection across diverse populations 💪💉

@jqsiu.bsky.social and colleagues’ work here: doi.org/10.1016/j.eb...

Find the paper in our December 2025 issue:
➡️ doi.org/10.1016/j.eb...

Colorful pills and capsules on blue background. Image copyright Tania Ivanova – Getty Images.

There is a growing need for non-opioid pharmaceutical alternatives for effective chronic pain treatment

@laurahuckins.bsky.social @kjohnst9.bsky.social et al. developed a novel genetics-informed framework for drug repurposing, leveraging existing genetic and transcriptomic data resources 💊🧬

A mosquito is pictured in silhouette. The headline reads "First-in-class drug candidate offers hope in malaria fight"

A new study by WEHI and MSD researchers has unveiled a first-in-class antimalarial drug candidate that targets two essential parasite enzymes across multiple life stages.

Published in @ebiomedicine.bsky.social

www.wehi.edu.au/news/new-ant...

Thrilled to share our paper is out now in @ebiomedicine.bsky.social 🥳 The interoception accuracy part is still my favorite 🤩 Have a look: www.thelancet.com/journals/ebi...

Full text open access link here: www.thelancet.com/journals/ebi...

Between 2006–2008, swine abattoir workers developed a nerve disorder linked to inhaled porcine neural tissue. 🐖🧠A new study identifies synaptophysin-IgG & GAP43-IgG as key biomarkers, also seen in non-exposed patients with a treatable inflammatory polyradiculoneuropathy
#autoimmunity #neuropathy
🔗⬇️

The December 2025 issue of eBioMedicine is now live!

On this month’s cover:

🧑‍⚕️ The accelerating pace of ALS research

🔬 AI-driven immune profiling from histopathology slides to predict chemo-radiotherapy outcomes in rectal cancer

🏘️☀️ Age and livability in a hotter climate

Promotional card. Contact Rida Ansari regarding content enquiries at rida.ansari@lancet.com. Copyright: Elsevier Ltd.

Senior Editor at eBioMedicine Rida Ansari (@ridaansari.bsky.social) is looking forward to attending @britishneuro.bsky.social #neuroscience Festive Symposium in London, and welcomes queries from attendees!

Learn more about our scope and global reach & impact here: hubs.li/Q03BLdg_0

Promotional card. Contact Rida Ansari regarding content enquiries at rida.ansari@lancet.com. Copyright: Elsevier Ltd.

Senior Editor at eBioMedicine, Rida Ansari (@ridaansari.bsky.social), is looking forward to attending @crick.ac.uk Translational Research Symposium in London, and welcomes queries from attendees!💡🧪

Learn more about our scope and global reach & impact here: hubs.li/Q03BLdg_0

Volatile pyrethroid spatial repellents for preventing mosquito bites: a systematic review and meta-analysis VPSRs offer protection from contact with mosquitoes, with semi-field studies reflecting field data and species-level differences observed. HLC provided the best quality data. Additional field studies ...

A relatively new class of insecticide called “spatial emanators” offer protection from mosquito-borne diseases such as malaria, dengue, West Nile, yellow fever, and Zika. This meta-analysis of more than 25 years of research provides clarity on how to test these products and how well they work.

Summary of main changes in CONSORT 2025. Copyright: 2025 The Author(s). Published by Elsevier Ltd. CC BY 4.0

First published in 1996, the CONSORT statement was designed to improve the quality of reporting and provide a minimum set of items to be included in a report of a randomised trial.

Now, there is an updated 2025 Statement.

Find it here: tinyurl.com/2s3hv3yx

Antipsychotic and pharmacogenomic effects on cross-sectional symptom severity and cognitive ability in schizophrenia Our results confirm the importance of taking account of medication history (and particularly antipsychotic type and dose) in assessing potential correlates of cognitive impairment or poor functioning ...

📝 NEW on schizophrenia: @cumedicengage.bsky.social researchers found links between 💊 medication variables & cognitive ability & 🧬 pharmacogenomic variation with positive & negative symptom severity ✨. Based on dimensions from a CFA of validated questionnaires 🧑‍💻
Funding: @mhrukcharity.bsky.social

Common chemicals in plastic linked to over 350,000 deaths from heart disease Researchers estimate that exposure to phthalates contributes to 13 percent of all heart disease deaths in people between 55 and 64 years old each year.

A set of chemicals found in food packaging, plastics, and lotions and shampoos has been linked to hundreds of thousands of deaths from heart disease, according to a study published Tuesday in the journal eBioMedicine.

Cover figure presenting main results from the paper. Left: altered spectral power and covariance difference between AD progressers and stable MCI patients. Right: multivariate analysis, highlighting the complementarity of MEG covariance spectra, MRI cortical volumes and baseline control measures.

🩺🧠 ✨Excited about our latest work published in @ebiomedicine.bsky.social! In the BioFIND dataset, we found that brain activity provided unique information about progression to Alzheimer’s Disease (AD). #neuroskyence Paper: www.thelancet.com/journals/ebi...; Thread 🧶 ⤵️