Kelsey Person

#SfN2025 here we come! I am thrilled to be joined at the Society for Neuroscience meeting this year by Madelyn Moore, @kelseyperson.bsky.social, @valeriarobleto.bsky.social, and Crystal Lemchi. If you are in San Diego for the conference, please stop by to say hi! 👋 🧪🧠🟦

Scientists at Sanford Burnham Prebys, the University of Minnesota and Duke University report in Nature that “biased modulators” can target GPCRs more precisely—expanding potential drug targets and reducing side effects. www.nature.com/articles/s41...

'Molecular glues' and 'bumpers' offer new hope for precision medicines New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest receptors into precision tools—opening the door to a new generation of safer, smarter medicines.

Newly designed molecules acting as "molecular glues" and "bumpers" can selectively rewire GPCR signaling, offering a pathway to more precise and potentially safer medicines. doi.org/g98xfp

Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor subtype preference.

Nature research paper: Designing allosteric modulators to change GPCR G protein subtype selectivity

go.nature.com/49jaBQS

Thanks!!

Thank you!!

Huge shout out to my co-first author Maddi Moore, my amazing PI @laurenslosky.bsky.social & our incredible postdoc @valeriarobleto.bsky.social! A big thanks to our collaborators as well as our entire team🎉

Designing allosteric modulators to change GPCR G protein subtype selectivity - Nature Studies of the G-protein-coupled receptor NTSR1 show that the G protein selectivity of this receptor can be modified by small molecules, enabling the design of drugs that work by switching receptor su...

Excited to share that my co–first author paper has been accepted in @nature.com 🎉

We show that small molecules binding at the GPCR-transducer interface can predictably switch G protein selectivity - paving the way for structure-guided, pathway-selective drug design.

www.nature.com/articles/s41...

Save The Date graphic for the Black In Neuro Conference 2025. The top features a large group photo of diverse participants posing together in front of a "Black In Neuro" sign. Below the image is the Black In Neuro logo and bold orange text reads “BLACK IN NEURO CONFERENCE.” Event details follow: “Wednesday, Sept 10 - Friday, Sept 12, 2025, Washington, DC.” A note states: “A 2.5-day in-person event highlighting and celebrating Black neuroscientists globally.” Colorful geometric patterns frame the top and bottom of the design.

🎉BIN is turning 5️⃣—and going in-person for Black In Neuro Conference 2025 in Washington, DC 🧠✨
🗓️ It's time to save the date: September 10-12, 2025

Let’s celebrate 5 years of community, connection, and Black excellence in neuroscience!

More details to come soon!! 🤗

Our 28-yr U-RISE/MARC NIH grant that has served over 500 students and made us one of the top institutions producing African American students who go on to receive MD/PhDs in the United States was just cancelled yesterday. What a unnecessary and tragic end to such an impactful program...

Congratulations!!🫶🏾🎉

Excited to share this! Check it out!👇🏾👇🏾

#BlackInNeuro Starter Pack v1! Let us know if we missed you. #BlackInSTEM #Neuroscience 🧪

go.bsky.app/F8PpdPe