Bacterial Schlafen proteins mediate phage defence
(new work from @anemudraia.bsky.social and @artemnemudryi.bsky.social labs)
www.nature.com/articles/s41...
Schlafens are an ancient, mechanistically conserved family of tRNA-targeting immune effectors.
Out Now! Conditional activation of Cas13 enforces lysogeny in a native type VI-A CRISPR host #MicroSky
Out Now! Bacterial Schlafen proteins mediate phage defence #MicroSky
Excited to see this in print! Congratulations @artemnemudryi.bsky.social and @anemudraia.bsky.social!!
Congratulations Sam, very cool story!
CBASS is a cyclic nucleotide-based antiviral system in bacteria that is related to cGAS-STING signaling in animals. One of the big questions is how CBASS is activated during phage infection? We made some progress on this during my final year in the Kranzusch lab.
www.biorxiv.org/content/10.6...
Out today: We discovered new viral proteins that target immune signaling molecules, solely based on their AlphaFold-predicted shapes
www.science.org/doi/10.1126/...
Congrats Nitzan Tal and coauthors! Thank you Kranzusch lab for the fun collaboration!
Linking below previous thread on our findings
@nitzantal.bsky.social @romihadary.bsky.social @soreklab.bsky.social use structure prediction and in silico binding site analysis to discover viral immune evasion proteins! Exciting for our lab @reneechang.bsky.social @riveralopz.bsky.social to help with this project.
www.science.org/doi/10.1126/...
Out now! In collaboration with Leifu Chang, we uncover the molecular and structural underpinnings of CRISPR-Cas12f-like RNA-guided transcription systems!
Links to the published articles:
tinyurl.com/55kpavet
tinyurl.com/sk6djwx3
Previous thread for the preprint:
bsky.app/profile/did:...
Stunning new structural analysis and mechanism for Tmn anti-phage defense by @fnobrega.bsky.social
www.biorxiv.org/content/10.6...
In our latest work, we characterise the Tmn defence system. We reveal plasmolysis as a new way to block phage infection, dramatically reducing secondary infections.
Predicting protein-protein interactions (PPIs) at proteome scale can take months with co-folding models due to the massive all-vs-all comparisons required.
We are excited to announce FlashPPI, a contrastive learning framework that predicts proteome wide physical interfaces in minutes. 1/π§΅
Congratulations Cees! Very well deserved!
Congratulations to Sonomi Yamaguchi for her paper at @nature.com. Sonomi discovered Clover defense and explained how nucleotide signals control each step of viral sensing, immune regulation, and viral restriction β named for her beautiful "four-leaf" structures π
www.nature.com/articles/s41...
Congratulations Patrick! Happy to see this out!
1/6) Hot off the press @natsmb.nature.com π₯! Jasnauskaite et al. reveal how the minimal bacterial retron Eco2 defends against #phage π‘οΈ. Phage nucleases trigger Eco2, which cuts RNA, shuts down protein production and stops phage replication π¦ π«. #phagesky #immunity #microbiology #cryo-em rdcu.be/e4AyH
Great to see you here Adair and congratulations on this exciting new adventure!
π§¬πOnline @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...
Amazing findings in geometry-based immune activation! Two bacterial defence systems detect phage-encoded ring oligomers, assemble high-order molecular complexes, and trigger abortive infection.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Really phenomenal work from the Gerdt lab at Indiana University... I hope this becomes a major boon for phage therapy:
"Chemical inhibition of a bacterial immune system"
www.cell.com/cell-host-mi...
We found a new mode by which bacteria deplete NAD+ to protect from phages. And then we found how phages overcome this defense
Discovered by talented biochemist Dr Ilya Osterman, read the preprint: tinyurl.com/Narp-ap
A thread π§΅
A prophage-encoded abortive infection protein preserves host and prophage spread www.nature.com/articles/s41...
π¨ Hiring Alert! π¨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: π¦ Synthetic Biology andπ‘οΈ Bacterial Immunity. Come do great science with us in the middle of Paris! π«π·π₯ research.pasteur.fr/en/job/postd...
@jakob-tr.bsky.social @jrpenades.bsky.social et al. π₯!
www.science.org/doi/10.1126/...
Hello world! I am excited to announce my lab is open at the University of Utah in the Department of Biochemistry. We are looking for scientists at all levels interested in studying host-virus interactions in both bacteria and animals. Come join us in beautiful Utah! (photo is 10 steps from lab)
Preprint out: We characterise PUA-Cal-HAD, a widespread bacterial antiphage defence family. An infection cue switches a preassembled complex into an immune filament that drains dNTPs via a coupled two-enzyme cascade, and phage DNA mimics can block filament assembly (anti-polymerisation).
Out Now! A phage protein screen identifies triggers of the bacterial innate immune system #MicroSky
Illustration of gene flow along the succession of events leading from a simple archaeal ancestor through the more complex Asgard intermediate capturing the proto-mitochondrial alphaproteobacterial endosymbiont to the LECA. The wide coloured shape denotes the dominant trend of the origin of eukaryotic genes from Asgard ancestors, with light blue portions corresponding to archaeal evolution and the light brown portion to the evolution of protoeukaryotes starting with the alphaproteobacterial endosymbiosis. The purple arrows denote the smaller, piecemeal contributions of gene influx from various bacteria that are posited to have been occurring at all stages of the depicted evolutionary scenario.
Asgard archaea may have facilitated the evolutionary development of the mitochondria via endosymbiosis of Ξ±-proteobacteria at some point between the first eukaryotic common ancestor (FECA) and the last eukaryotic common ancestor (LECA)! π§ͺ
www.nature.com/articles/s41...
Many congratulations Martijn!
Many congratulations Francois and well deserved!
