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Tommaso Patriarchi

@tpatriarchi

Assistant Prof. at UZH πŸ‡¨πŸ‡­ | protein engineering for pharmacology and neuroscience | opinions my own

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02.12.2024
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Latest posts by Tommaso Patriarchi @tpatriarchi

Thank you very much Addgene! We're very glad to share the tools to the community for their broadest implementation :)

27.02.2026 08:16 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Addgene: Next-generation multicolor indicators for in vivo imaging of norepinephrine

All plasmids now available on Addgene: go ahead and use them!! :) www.addgene.org/browse/artic...

26.02.2026 16:54 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thank you Jonas!

26.02.2026 14:12 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

We hope these new tools will enable new amazing discoveries. Reach out if interested in collaborating of want to try them out!

26.02.2026 10:20 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Check out those localized NE release events imaged with 2P microscopy happening in L2/3 of mouse visual cortex during spontaneous awake behavior! (shout out to Sarah Ruediger at UCL for the beautiful data!)

26.02.2026 10:20 πŸ‘ 6 πŸ” 0 πŸ’¬ 2 πŸ“Œ 0
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Next-generation multicolor indicators for in vivo imaging of norepinephrine - Nature Methods Improved red and green indicators for norepinephrine and their characterization are reported. These indicators allow detection of norepinephrine release in awake behaving mice in dual-color fiber phot...

The most sensitive green and red #norepinephrine #sensors engineered to date are out in #naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @erc.europa.eu @snsf.ch doi.org/10.1038/s415...

26.02.2026 10:20 πŸ‘ 56 πŸ” 29 πŸ’¬ 4 πŸ“Œ 2
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Feels like a pivotal moment. The president is screening a movie about his third wife and crying about a lawsuit challenging his guilded ballroom, while good-hearted Americans looking out for their neighbor are getting murdered by state police. Will Americans finally wake up?

25.01.2026 17:55 πŸ‘ 10 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Excited to share our new preprint! We explore the link between the locus coeruleus (LC) and arousal for astrocytes, pyramidal cells, interneurons in the hippocampus. A fantastic collaboration with @sianduss.bsky.social @bohaceklab.bsky.social, and many others: www.biorxiv.org/content/10.6... 1/5

19.01.2026 13:36 πŸ‘ 65 πŸ” 20 πŸ’¬ 1 πŸ“Œ 1

An engineered nanobody inhibitor for molecular-to-circuit control of opioid receptor function. This was a really fun collaboration with @miriamstoeber.bsky.social and @amanglik.bsky.social labs, check it out! www.biorxiv.org/content/10.6...

18.01.2026 12:23 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains A family of rationally designed time-resolved fluorescent proteins with controllable lifetimes across the visible spectrum enables simultaneous multiplexed live imaging, super-resolution microscopy, a...

Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains.
Is it impressive? Yes
Is it new? No
Should you use it? Probably not.
www.cell.com/cell/fulltex...

26.09.2025 08:07 πŸ‘ 20 πŸ” 4 πŸ’¬ 1 πŸ“Œ 2

Congrats Martin, great work!

28.08.2025 07:09 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Amazing work by the Andermann Lab showcasing a perfect use-case for FLIM imaging of dopamine sensors - looking at tonic [DA] changes and adaptations over days! Honored to be part of this effort.

06.06.2025 10:30 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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#BlueskyResistance #Voices4Victory #ProudBlur
Advertisement at a London bus stop. Ya gotta love the British…

24.02.2025 14:58 πŸ‘ 40556 πŸ” 11390 πŸ’¬ 514 πŸ“Œ 589
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Topological segregation of stress sensors along the gut crypt–villus axis - Nature Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of t...

www.nature.com/articles/s41...

This study is absolutely mind-blowing.

23.02.2025 13:51 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congratulations Tal!! It's so great to see this out, I am very happy for you and your lab!!

20.02.2025 16:55 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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REQUIREMENTS:
β€’ Master’s degree in Biotechnology, Biochemistry, Bioengineering, Molecular Biology or a
related discipline.
β€’ good experience in (and/or): molecular cloning, mammalian cell culture, microscopy, FACS
β€’ Good organizational skills, attention to details, reliability, and teamwork

10.02.2025 11:17 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Our lab has an open PhD student position in Protein Engineering - Neurotechnology. Apply if interested!

10.02.2025 11:17 πŸ‘ 7 πŸ” 8 πŸ’¬ 1 πŸ“Œ 1

Amazing work by @massecklab.bsky.social PinkyCaMP the first mScarlet based Ca2+ indicator! Congrats to all, proud to have contributed to this

18.12.2024 10:52 πŸ‘ 6 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Thank you Tal!!

15.12.2024 07:57 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Extremely proud to see my second PhD student (now Dr.) Xuehan Zhou defending her thesis so brilliantly and successfully! Such happy moments :)

13.12.2024 08:22 πŸ‘ 6 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Our lab is looking for a motivated Research Assistant with hands-on experience with molecular cloning techniques, mammalian cell culture and confocal imaging. If you are interested in joining or know anyone who is, please email me your application. Thanks

13.12.2024 08:16 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

This is really fascinating work, congrats to the whole team!

05.12.2024 12:12 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019).

The renamed:

Bluesky-sized history of neuroscience (biased by my interests)

01.12.2024 20:29 πŸ‘ 626 πŸ” 203 πŸ’¬ 14 πŸ“Œ 14