Thanks to the Danish Diabetes and Endocrine Academy (#DDEA) and @carlsbergfondet.dk for making this event possible, including Travel & Accommodation Support for Early-Career Researchers 👇
ninaziegenbein.github.io/wricaarhus20...
Check out this meeting on whole-room indirect calorimetry in Denmark!
Submit your abstract and join international peers to share ideas and spark new collaborations 👇
Free registration: ninaziegenbein.github.io/wricaarhus20...
@stenoaarhus.bsky.social @cbmr.science @zgerharthines.bsky.social
It build upon this recent paper from Rémi Montané, Audrey Carriere and colleagues published in @jphysiol.bsky.social
4/4
Jacob With Christensen, David Tandio (@davidtandio.bsky.social), Matthias Anagho-Mattanovich, NNF Center for Basic Metabolic Research (@cbmr.science) 3/4
Is it primarily fueling thermogenesis? And what about its potential role as a hormone-like metabolite? Check out our piece below discussing these and several other unanswered questions about lactate and adipose thermogenesis 👇2/4 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Circulating lactate is being taken up by cold-activated thermogenic adipose tissue in mice - but why? 🔥 Despite 4 decades of research on the role of lactate in brown fat, we still do not really know what lactate is doing inside this tissue 1/4 - source: physoc.onlinelibrary.wiley.com/doi/10.1113/...
CBMR's Zach Gerhart-Hines is awarded the first Flemming Quaade Prize for Outstanding Obesity Research for his pioneering discoveries on how fat tissue influences insulin sensitivity, energy expenditure, and appetite control.
Read more: cbmr.ku.dk/news/2025/za...
#obesity #metabolism
A framework from @easoobesity.bsky.social to guide pharmacological treatment of 'fat mass diseases' versus 'sick fat diseases' 👇
www.nature.com/articles/s41...
⚖️ I will also provide critical perspectives on some of the other ‘hyped’ metabolites that are claimed to have “anti-obesity” effects . . .
@cbmr.science
😱 I will present two ‘horror stories’, one on lactate and one on pyruvate (unpublished), illustrating major overlooked methodological problems in e.g. metabolic toletance tests used to assess glucose homeostasis. 3/4
@clemmensenc.bsky.social @zgerharthines.bsky.social
Then you should join the @easdnews.bsky.social Rising Star Symposium tomorrow (thursday) at 🕗 08.30-10.10 in📍London Hall (or online). 2/4
Are you using metabolic tolerance tests in your research? 💉Are you interested in metabolites? Or do you study the effects of exercise? 🏃🏻♂️➡️ 1/4
👉 Legacy effect
👉 Novel subtype of T2D
👉 MASLD screening in newly diagnosed T2D
👉T2D and cardiorenal comorbidities
👉 Stressors and MetS
👉 Psychosocial inequality and foot compl. in newly diagnosed T2D
👉 Sex diff. in vascular compl.
👉 How MetS contributes to global disease burden
Then join the epidemiology-focused short oral discussion session (Event A) today (Tuesday) from 12.00 – 13.00 at Station 03 in Hall C. It will include presentations on 👇 2/3
Are you at the 61st @easdnews.bsky.social meeting this week? And are you working with metabolic and vascular complications of diabetes - or do you just want a brief break from the omnipresent and rapidly progressing developments in pharmacotherapies for obesity and cardiometabolic diseases? 1/3
As the world focuses on its billion-plus obese citizens, there remain people at the other end of the spectrum who are skinny, often painfully so, but don’t want to be. This recent @knowablemag.bsky.social article explores the “real enigma” of a condition. knowablemagazine.org/content/arti...
In a world focused on obesity, there remain people who struggle to gain weight. Genetic differences play a role.
Take-home 📨: Thin people are battling their own biology. The forces they try to overcome to gain weight are similar, if not the same, to those that people with high BMIs fight when trying to lose weight 👉 illustrating that biology largely determines our body weight!
www.nature.com/articles/s41...
. . . . as discussed by myself, @zgerharthines.bsky.social and @clemmensenc.bsky.social in this open access paper from @cp-trendsendomet.bsky.social 7/8
www.cell.com/trends/endoc...
But there are also people that seem to eat more than they burn. The observation that certain individuals with constitutional thinness remain weight stable while seemingly eating more calories than they expend might be explained by increased loss of calories in the toilet 💩 6/8
But what might explain weight gain resistance in people with constitutional thinness? For some thin people,
enhanced satiety might play a role 🍔 For others, increased energy expenditure could be an answer 🔥 as suggested by
@johnspeakman4.bsky.social's group 5/8
www.cell.com/cell-metabol...
The numerous anecdotes and stories appearing in this network illustrate that:
1) Weight stigma hits both ends of the BMI spectrum!
2) People with thinness might also help us improve the treatment of other cardiometabolic diseases! 4/8
royalsocietypublishing.org/doi/10.1098/...
In 2020, I started building a network for people living with constitutional thinness. This group now has more than 600 members that report to live with a persistent and healthy form of thinness. 3/8
Building on work by Mélina Bailly et al., and myself and @clemmensenc.bsky.social, the article illustrates how constitutional thinness might hold the keys for better understanding obesity and finally unlocking its ‘The Gordian Knot’, i.e. preventing overweight. 2/8
annualreviews.org/content/jour...
If our environment promotes obesity, why do some people stay thin? 🤔
This new popular scientific article by Ute Eberle in
@knowablemag.bsky.social delves into this question 👇 1/8
@cbmr.science
knowablemagazine.org/content/arti...
Can we harness the biology behind weight gain resistance in people living with constitutional thinness to prevent and better treat obesity and cardiometabolic diseases? 👇 @cbmr.science
royalsocietypublishing.org/doi/10.1098/...
Latest publication from the lab spearheaded by @shoreseashell.bsky.social & in collaboration with @zeqiraj.bsky.social is out. Using structural, biochemical & computational tools, this work sheds light on the mechanism of action of BAY-3827 in inhibiting #AMPK 1/3
www.science.org/doi/full/10....
In the Journal Club, we highlight potential uses, together with key limitations, of a novel mouse model for studying lactate biology. It is freely available. Take a look if you're into e.g. metabolite or exercise biology👇
physoc.onlinelibrary.wiley.com/doi/10.1113/...
We wrote one of these last year and I'm really happy to see the above recognition of our work which was led by @niclasrausch.bsky.social when he was visiting the @zgerharthines.bsky.social Lab at the @cbmr.science. 2/3
@jphysiol.bsky.social, and several other journals, has a 'Journal Club' format targeted to early-career researchers. It is a great opportunity for young scientists to get started with scientific writing and cultivating independent thinking. Check it out! 1/3
