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Tim Machado

@timmachado

Presidential Assistant Professor of Neuroscience at UPenn ๐Ÿง  Previously: Postdoc at Stanford, Columbia PhD, CTRL-labs Co-founder.

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08.09.2023
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Latest posts by Tim Machado @timmachado

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How do neural circuits generate the walking rhythm?

Using connectome simulations, @sarahpugly.bsky.social found a minimal central pattern generator (CPG) that produces oscillations in leg motor neurons. Same circuit motif for each ๐Ÿชฐ leg.

w @bingbrunton.bsky.social

www.biorxiv.org/content/10.1...

09.12.2025 17:50 ๐Ÿ‘ 73 ๐Ÿ” 35 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 2
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Summer Undergraduate Research Experience | HHMI The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

Calling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our โ€™26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nationโ€™s top scientists โ€” learn more: bit.ly/CechFellows

18.11.2025 14:44 ๐Ÿ‘ 70 ๐Ÿ” 88 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 12
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New preprint:

Neural manifolds that orchestrate walking and stopping

Here we develop a new theory for neural generation of walking and how it can stop- Next we test the theory using Neuropixels probes in the lumber spinal cord of freely moving rats. See more:

www.biorxiv.org/content/10.1...

09.11.2025 21:33 ๐Ÿ‘ 72 ๐Ÿ” 18 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 3
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Decoding inner speech. A volunteer who cannot speak imagines saying the sentence on the screen. A computer decodes the signals from an implant in her brain and correctly guesses what she's saying to herself. Here's my story (gift link): nyti.ms/3UpEiat

14.08.2025 15:14 ๐Ÿ‘ 135 ๐Ÿ” 37 ๐Ÿ’ฌ 9 ๐Ÿ“Œ 5
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Fear and loathing on study section: Reviewing grant proposals while the system is burning As grants are canceled, delayed and subject to general uncertainty, participating in study sections can feel futile. But itโ€™s more important than ever.

i wrote an essay for @thetransmitter.bsky.social about what it feels like to serve on an NIH grant review panel (study section) right now

www.thetransmitter.org/craft-and-ca...

14.07.2025 18:49 ๐Ÿ‘ 126 ๐Ÿ” 58 ๐Ÿ’ฌ 8 ๐Ÿ“Œ 5

Rats blink at ~5 blinks/min, which is like 3x less than humans. But mice only blink once every couple of minutes and often sleep with their eyes open.

10.06.2025 18:39 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Emotions are core to the human experience ๐Ÿ˜†๐Ÿ˜ฎ๐Ÿ™‚๐Ÿ˜Šโ˜น๏ธ๐Ÿ˜ ๐Ÿ˜ณ๐Ÿ˜‘
But how do they arise? Our brain-wide โšกrecordings in humans and mice reveal some answers @ScienceMagazine. A big team effort and debut paper from @Stanford's new Human Neural Circuitry program. bit.ly/4dEyX7Z

30.05.2025 17:33 ๐Ÿ‘ 27 ๐Ÿ” 9 ๐Ÿ’ฌ 2 ๐Ÿ“Œ 0
Research.gov :: GRFP

๐Ÿšจ Not a drill: NSF GRFP results are NOW OUT!!!!!

But...good news and bad news.

๐Ÿ‘ I'm *thrilled* for the grad students for whom getting this award will be life-changing, esp now.

๐Ÿ‘Ž # of fellowships went down by 51%

(1000 this year vs. 2036 last year)

See here: www.research.gov/grfp/Awardee...

08.04.2025 04:22 ๐Ÿ‘ 329 ๐Ÿ” 192 ๐Ÿ’ฌ 14 ๐Ÿ“Œ 38
New survey data out from Navigator research shows the profound public concern and anger over the cuts in the Musk wilding spree.
Unsurprisingly, voters are more concerned than almost anything by Trump and Musk shutting down cancer cure research (and research into cures for other diseases) in the
U.S. 71% of independents says they're concerned or very concerned about it. 65% percent of voters over all. It's also something they've heard the least about. Here's the raw data for the poll and a powerpoint.
And here's the chart on Elon and the
billionaires.
"Dangerous," "Power-Hungry," "Corrupt," and "Self-Serving" Are
Best Descriptors of Musk and Other Billionaires' Actions
Independents see them most as "dangerous,"
the job he is doing ao say they da greedy Oligarchic. American and inexpariEnced est lower across the body approve of
* and "inexperienced" test lower across the board.
Which of the following words or phrases best describes the actions of Elon Musk and the other billionaires working with the Trump administration?
2024 Trump Voters*
Dem
Rep
Not-Strong Approvers
Strong
Approvers
Dangerous
134%
Power-hungry
134
Corrupt
131
Self-serving
Greedy
129
MAGA
Unaccountable
Unelected
119
illegal
Right-wing extremist
Out-of-touch
115
114
Inexperienced
Un-American IK
Oligarchic Ik
For more info, visit navigatorresearch.org
n

New survey data out from Navigator research shows the profound public concern and anger over the cuts in the Musk wilding spree. Unsurprisingly, voters are more concerned than almost anything by Trump and Musk shutting down cancer cure research (and research into cures for other diseases) in the U.S. 71% of independents says they're concerned or very concerned about it. 65% percent of voters over all. It's also something they've heard the least about. Here's the raw data for the poll and a powerpoint. And here's the chart on Elon and the billionaires. "Dangerous," "Power-Hungry," "Corrupt," and "Self-Serving" Are Best Descriptors of Musk and Other Billionaires' Actions Independents see them most as "dangerous," the job he is doing ao say they da greedy Oligarchic. American and inexpariEnced est lower across the body approve of * and "inexperienced" test lower across the board. Which of the following words or phrases best describes the actions of Elon Musk and the other billionaires working with the Trump administration? 2024 Trump Voters* Dem Rep Not-Strong Approvers Strong Approvers Dangerous 134% Power-hungry 134 Corrupt 131 Self-serving Greedy 129 MAGA Unaccountable Unelected 119 illegal Right-wing extremist Out-of-touch 115 114 Inexperienced Un-American IK Oligarchic Ik For more info, visit navigatorresearch.org n

ICYMI (especially if you work in Democratic politics):

Cutting cancer research is one of the things Americans are most worried about.

And one of the things theyโ€™ve heard the least about. According to polls from @navigatorsurvey.bsky.social:
1/

23.03.2025 18:03 ๐Ÿ‘ 697 ๐Ÿ” 303 ๐Ÿ’ฌ 18 ๐Ÿ“Œ 18