Happy to share our new pre-print on the dependency of ALT-positive tumors on the DNA translocase SMARCAL1. Outstanding work of @angelotaglialatela.bsky.social in collaboration with the Min, Lazzerini Denchi and @cejkalab.bsky.social laboratories! www.biorxiv.org/content/10.6...
Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...
67th ASH Annual Meeting Original Article | Dec. 8, 2025 | NEJM.org Universal Base-Edited CAR7 T Cells for T-Cell Acute Lymphoblastic Leukemia Figure 2F. Minimal Residual Disease before and after Receipt of BE-CAR7 T Cells. The NEJM identity sits at the bottom.
In relapsed or refractory T-cell acute lymphoblastic leukemia, off-the-shelf allogeneic base-edited CAR7 T cells mediated responses in 11 patients, enabling stem-cell transplantation in 9 patients in deep remission. Full study results: nej.md/48wiyQL
#ASH25 | @ash.hematology.org
❄️The 2026 Winter Session of GIIN Webinars is here! Join us on the first Tuesday of each month at 5 PM (Rome) / 11 AM (NYC).
No pre-registration needed, simply join via Zoom: uniroma1.zoom.us/j/95149984403
Want reminders? Subscribe here: docs.google.com/forms/d/e/1F...
New York Times article on science funding with some depressing but familiar curves with interactive graphics.
www.nytimes.com/interactive/...
The application deadline has been extended for a postdoc position in our lab until August 22. Please enquire/apply if you are interested in ADP-ribosylation, ubiquitination, genome stability or immunity.
my.corehr.com/pls/uoxrecru...
A postdoc position is available in our lab to study ADP-ribosylation and ubiquitylation signalling! We are looking for someone with experience in structural biology and biochemistry. The application deadline is June 20th.
my.corehr.com/pls/uoxrecru...
The patient, KJ, reaching out after infusion of the CRISPR therapy, with a big smile! Photo credit Children's Hospital of Philadelphia
In a medical breakthrough, a team including IGI’s
@urnov.bsky.social & @giannikopoulosp.bsky.social created an on-demand #CRISPR therapy for an infant with a deadly gene mutation — developed, approved, and delivered to the patient in just 6 months.
Read more: ow.ly/G0Bg50VTonC
#RareDisease 🧬
Three days, fresh data, & sparkly debates on how replication gaps drive cancer & disease. Grateful for every talk & discussion. Thank you for pushing science forward—next stop: great papers. Science moves fast when we move together!
Thanks to all the attendees of the Keystone Symposium on DNA Replication Gaps, Cancer, and Disease for a fantastic meeting! @cantorlab.bsky.social @labvincenzo.bsky.social
Wrapping up an insightful conference on DNA Replication Gaps, Cancer, and Disease! 🎉 Congrats to our Future of Science Fund winners, Larissa Milano and @seppai99.bsky.social! Your achievements inspire us. 🌟 #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
Thanks to all the authors for their excellent reviews! @penengolab.bsky.social @labvincenzo.bsky.social @cantorlab.bsky.social @quinet.bsky.social @vermalab-washu.bsky.social
Happy to share our DNA Repair special issue on the replication stress response curated with @vindignilab.bsky.social.
www.sciencedirect.com/special-issu...
Congratulations to the 2025 Canada Gairdner Award laureates! This year’s laureates represent some of the world’s most significant biomedical and global health research and discoveries.
Learn more about their award-winning research here: gairdner.org/resource-hub...
#GairdnerAwards
I'm happy to share that I've joined @ifomresearch.bsky.social as a Junior Group Leader, leading the Functional Genomics of Cancer Immunity Laboratory! 🔬
The lab investigates the links between DNA damage response (DDR) and cancer immunity. Exciting times are ahead—stay tuned!
Submit poster abstracts by 4/3, 11:59pm MST for DNA Replication Gaps, Cancer, and Disease in Daejeon, South Korea. Join experts to explore DNA errors and cancer. keysym.us/KSDNARep25.
youtu.be/_aPIkDQg1rw #KSDNARep25 @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇
Congratulations, Luke!
Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...
This is becoming not sustainable
Excellent Info Graphic. Share everywhere!
Join the first Keystone conference dedicated to DNA replication gaps and cancer! Send an abstract to be selected for a talk.
www.keystonesymposia.org/conferences/...
Join Helle D. Ulrich & experts this April to explore DNA replication errors, breaks, repair, and cancer! Submit abstracts and scholarships by Jan. 28 (11:59pm MST)! keysym.us/KSDNARep25
#KSDNARep25 #DNAreplicationgaps @cantorlab.bsky.social @albertociccia.bsky.social @labvincenzo.bsky.social
Please join the conversation and get your abstract in!
GET is finally published!
- Paper: t.ly/iQct_ (new validations, dry and wet)
- Model: t.ly/4jnUI (new tutorial on PBMC 10x Multiome data, and yes you can even fine-tune it on a Macbook)
- Analysis package: t.ly/OqLAL
- Demo: t.ly/rbFQB
- Docker: t.ly/86n_i
What are your plans for October 2025? It would be a fantastic time to visit Norway for the Endogenous DNA Damage and Repair conference with a stellar set of speaker covering a wide range of topics. www.endodnadamage.com
Delighted to publish my new molecular animation:
DNA Break Repair by Homologous Recombination
youtu.be/Xe-83tBcxhs
I'm honoured to speak at the upcoming Genome Instability & Cancer Conference, celebrating the legacy of Angelos Constantinou. His pioneering work transformed our understanding of DNA repair. Register now to join us near his home town in France in March! www.tribute2angelos.fr/page/home/
Congratulations, Orlando!
