Rob Schneider

Transposable elements are increasingly studied in single-cell data, but how reliable are current locus-level quantification methods in short-read scRNA-seq data?

If you work with single-cell RNA-seq or TEs, we hope this is a useful resource — feedback very welcome!

Very nice paper from @martingroth.bsky.social at IFE just out !Linking #metabolism and #epigenetics in
➡️ @natplants.nature.com

@helmholtzmunich.bsky.social @epihmgu.bsky.social
@valentin-ha.bsky.social

Fellowship application dealdine for students from low income countries 🌐will be in 1️⃣ week.
Dont miss out on this opportunity ! Hands on Summer School.
Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➡️Unique opportunity ! 15 exiting days ➕ Daily high profile lectures.
👉 bit.ly/4oGDR8f

Dont miss out on it ! Hands on Summer School.
Cut&Run, Cut@Tag, ChIP, ATACseq and analyse your own data ! ➡️Unique opportunity ! 14 exiting days ➕ Daily high profile lectures.
👉 Applications & info: bit.ly/4oGDR8f

Great to catch up with alumni @nchoy.bsky.social who stopped by to visit the lab. So great to hear about your internship adventures with @robertife.bsky.social and see you doing so well!

Thanks Kinga !

Thanks Rob !

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations Nitsch et al. show that short-chain acylations of histone H4K16, acetylation (C2), propionylation (C3), and butyrylation (C4) modulate chromatin structure in vitro. These effects can translate in vivo...

Now final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social

Enjoy 👇👇 www.cell.com/molecular-ce...

Epigenetics Update - Cell-cycle-dependent repression of histone gene transcription by histone H4 go.nature.com/4bjE521

Kami Ahmad and Steven Henikoff (Fred Hutchinson Cancer Center) reporting in NSMB

#Epigenetics #Histones
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Perfect for cancer, immunology, and aging research; epigenometech.com

Excited for this new preprint from my lab where we unexpectedly found a role for methionine synthase reductase in regulating heterochromatin independently of methionine synthesis 👇

Thanks Rob !

Thank you Hiten !

Hidden sampling biases inflate performance in gene regulatory network inference Accurate reconstruction of gene regulatory networks (GRNs) from single-cell transcriptomic data remains a major methodological challenge. Recent machine learning approaches, particularly graph neural ...

Our new preprint is out: www.biorxiv.org/content/10.6...
We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs.
A reminder of why bias-aware evaluation matters!

🎉 Wrapping up 2025 with EpiCrossBorders!
A year of breakthroughs, cross-border exchanges, multiple publications & vibrant outreach.
Next stop: 2026 Symposium in Edinburgh + new workshops & theses submissions
Thank you to all who made this possible. 🌐 #Epigenetics #PhDprogram #Sciencecollaboration

H4K16 acylations destabilize chromatin architecture and facilitate transcriptional response during metabolic perturbations Histone modifications play crucial roles in genome function. However, how chromatin integrates physiological and metabolic responses at the molecular …

Excited to share new manuscript on histone acylations, exploring how H4K16 acylations regulate inter and intranucleosomal interactions and how they confer resilience to metabolic challenges in vivo. Thanks to all authors +1 author @sandrani.bsky.social Enjoy 👇👇
www.sciencedirect.com/science/arti...

Summary - Summer School on Chromatin Biology: A Hands-On Expedition

👉 Chromatin Summer School 2026 – Apply Now!
Join us in Munich 17–29 August 2026 for an immersive program on chromatin biology:
🔬 Expert lectures
🧪 Hands-on training
🤝 Global networking
Open to 14 PhD students worldwide (sponsorship available)
👉 Apply here: bit.ly/4oGDR8f
#ChromatinBiology

Please RT 📧
Registration open for ➡️"Summer School on Chromatin Biology" Our 2 weeks hands on expedition 🧪👩‍💻August 2026. 3. edition. Learn CUT@Tag, CUT@Run, ChIPseq, ATACseq AND to analyse your own data at @helmholtzmunich.bsky.social Daily letures by experts in the field !

▶️ shorturl.at/jrA8i

A Platform for Emerging Talent: The Helmholtz Munich Talent Forum 2025

🌍 The #HelmholtzMunich Talent Forum 2025 brought together exceptional early-career scientists in #epigenetics & nucleic acids research to foster exchange, collaboration & research excellence. 👩‍🔬👨‍🔬

👉 t1p.de/3dsix

@boyanbonev.bsky.social @epihmgu.bsky.social
#TalentForum

The Helmholtz Munich Talent Forum (Nov 18–19) brought 8 emerging global talents in epigenetics & nucleic acids research to our Neuherberg Campus! Inspiring talks, a keynote by @boyanbonev.bsky.social & vibrant networking—science at its best! bit.ly/4o2ftxr

Science thrives through engagement and this weekend proved it!
The “Stem Cell Stories” exhibition @ Deutsches Museum showcased the power of outreach.
A shout-out to our EpiCrossBorders students, who played a key role in connecting with the public and sparking curiosity.
#ScienceOutreach

Wrapping up a great weekend of “Stem Cell Stories” at the Deutsches Museum.
Science doesn’t exist in isolation. We are committed to engaging with society, exchanging ideas, and building trust through transparency. Let’s keep the conversation going.
#ScienceOutreach #Epigenetics #AIinBiomedicine

We are ready! Our team have been working all day to set up the interactive exhibition "Stem Cell Stories" at Deutsches Museum. Join us and explore the world of cell identities.

📅Fri 14 - Sun 16 Nov
📍Deutsches Museum, Munich
⏲️09:00 - 17:00 daily

Find out more: bit.ly/4p9Jk8m

Fantastic breakthrough for Type 1 Diabetes by @helmholtzmunich.bsky.social

Our EpiCrossBorders students have helped turn science into stories!

Stem Cell Stories - an exhibition on cell identitity (Nov 14 - 16) at Deutsches Museum.

Also, don't miss the panel discussion on Friday 14 Nov: AI in biomedicine and the ethical questions it raises (in German). bit.ly/4qMnb1y

James Watson, Who Helped Discover the Structure of DNA, Is Dead at 97

James D. Watson died on Thursday in East Northport, N.Y., on Long Island. He was 97.

www.nytimes.com/2025/11/07/s...

Decoding Oat Diversity for a Climate-Resilient Future

Decoding #Oat Diversity for a #Climate-Resilient Future🌾

This study provides valuable insights into how oats adapt to their environments – paving the way for more robust, climate-smart crops.

👉 t1p.de/gmmgb

@leibniz-gemeinschaft.de @natureportfolio.nature.com @tum.de

“Translating complex science into something simple, yet meaningful is never easy.” 💬
Our #EpiCrossBorders PhD researchers are learning just that — turning #epigenetics into connection, curiosity & conversation at the Deutsches Museum.
📍14–16 Nov | #StemCellStories #SciComm #PhDLife

Molecular Biosystems Conference Youtube Home Page for the Molecular Biosystems Conference (molbiosystems.com), the premier Latin American meeting on gene regulation.

The #MBioSys25 keynote lectures by Prof Caroline Dean (@johninnescentre.bsky.social) and Prof @elowitzlab.bsky.social (Caltech) are now online!

Watch (or revisit!) these two inspiring talks on gene regulation & functional genomics, available for free on our channel

www.youtube.com/@MolecularBi...

Great discussions & attendance @helmholtzmunich.bsky.social in our yearly #Epigenetics Spotlight meeting organised by @robertife.bsky.social and myself - thanks all for coming, our long-distance guests Giacomo ad Marc !! and all attendants for fantastic discussions - see you next year 🥳

Stem Cell Stories @ Deutsches Museum

Meet the EpiCrossBorders students behind the scenes—bringing science to life!

🧬 Join us Nov 14–16 | Free entry
🎤 AI & ethical implications in research roundtable: Nov 14, 18:30
#StemCellStories #NextGenScience #EpiCrossBorders #ScienceComm #DeutschesMuseum #AI