Max Haase

Thank you Adele for this wonderful synthesis of our work !! It was a pleasure to read this morning

Really nice to see @marstonlab.bsky.social's News & Views piece cover the evolution of budding yeast centromeres in @nature.com. Check it out for a clear and concise breakdown of @maxhaase.bsky.social’s new paper and ours! 🧬

What a fantastic News & Views piece in @nature.com from @marstonlab.bsky.social highlighting recent insights into yeast centromere evolution, including the recent paper from @helsenjana.bsky.social and our own.

Thank you Chris! Much of what I learned during my time in Madison shines through here too (yeast diversity, genomics, synteny, and phylogenetics)!

Congratulations to @maxhaase.bsky.social on his recent publication from his time in the Boeke Lab at NYU, where he used methods from the Y1000+ consortium! 🥳 We are very proud to have had him as an undergraduate student in our lab. med.nyu.edu/research/boe...

Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition Solid tumors harbor immunosuppressive microenvironments that inhibit tumor-infiltrating lymphocytes (TILs) through the voracious consumption of glucos…

"Nobody will care about your work about sugar metabolism and transporters in Neurospora crassa"

Nobody can predict what can happen with your work.

www.sciencedirect.com/science/arti...

Yes, my car was cheaper than my recent open access article.

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with retrotransposon-rich centromeres and that long-terminal-repeat retrotransposons are the genetic substrate.

Nature research paper: Ancient co-option of LTR retrotransposons as yeast centromeres

go.nature.com/4c3kP9A

Congrats!

Global reorganization of genome architecture at the transition to gametogenesis - Nature Structural & Molecular Biology Huang, Rigau and colleagues observe major changes in how DNA is organized in early germ cells before they start developing into sperm or eggs. These results show that germline removes structural ‘memo...

Happy to share our latest paper.

Our findings uncover a unique chromatin architecture and spatial chromosome arrangement in gonadal germ cells and document that alongside global DNA demethylation, the germline epigenetic reprogramming involves reorganisation of the 3D genome.

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila.

Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and
@buszczaklab.bsky.social!

www.biorxiv.org/content/10.6...

Thanks Gudjon!

Thanks Ben!

Thank you Gianni!

Thank you so much Harmit!

Thanks, Hiten!

I agree, it's absolutely incredible they were never recognized for their work by the Nobel committee!

Great thread on budding yeast centromere evolution!

(Bonus points for avoiding “it’s not x; it’s y” sentence structure) 😊

Thank you!

It's not that the sentence structure is too common, it's that its a pedantic way to write.

Thank you!!

Perpetually in awe of the astonishing creative capacity of retrotransposons in eukaryotic cell biology — makes you wonder what remarkable, still-hidden origin stories centromeres across the tree of life carry.

"Ancient co-option of LTR retrotransposons as yeast centromeres" #yeastevolution

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

Also, I must add that this project started during my PhD, and I am entirely indebted to Jef's support and his vision to think big.

I am honored that this got to be his last paper on yeast Tys!

fin+2/14

Thanks, Gali!

The first centromeres to be cloned (by chromosome walking) by Clarke and Carbon (should have won them a Nobel) were mysterious in their origin. Max et al have solved the mystery.

"In this model, two linked innovations—the single Cse4CENP-A nucleosome and the CBF3 complex—emerged before the canonical CDEI, CDEII, CDEIII structure, marking an early phase of sequence-dependent centromere evolution."

Thanks!!

Thanks! Me too, it was a totally unexpected result!

Thanks, Jana!

I would bet there is a link to E3 ubiquitin ligases as you suggest, since Skp1 is shared between CBF3 and SCF complexes.