Supported by my office doi.org/10.1161/CIRC...
Illustrates the need for enriched screening strategies for Lp(a) testing in a selective populations. 🧪
12.03.2026 10:35
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Supported by my office doi.org/10.1161/CIRC...
Illustrates the need for enriched screening strategies for Lp(a) testing in a selective populations. 🧪
www.sciencedirect.com/science/arti... 🧪. Interesting read on epistemic uncertainty quantification
I am very sorry to learn that Phil Bourne passed away yesterday March 8. He had a huge impact at NIH and in the data science community.
He was also a good mentor to many people including me.
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www.nature.com/articles/s41.... Just out. It’s a 3D VLM that learns from volumetric CT scans, electronic health record data and radiology reports.
www.nature.com/articles/s41... 🧪 researchers show that current ML and graph based approaches fail to learn biomarker-specific genotype–phenotype mapping; instead, they exploit aggregated phenotypes of interdependent biomarkers or cohort-specific association as proxies for prediction.
Survivorship of modern total hip replacement: systematic review, meta-analysis, and extrapolation of global joint registry data - The Lancet www.thelancet.com/journals/lan... 🧪 findings indicate roughly 92% 30 year survivorship suggests advances in bearing surface technology have improved.
link.springer.com/article/10.1.... 🧪 Work uses AI
to translate the genomic information of patients with cancer into pathway interactions and cross-talk. A pan-cancer analysis finds distinct patterns of pathway
interaction networks among different cancer types and potential drug target.
www.jacionline.org/article/S009... 🧪 This study identified 37 SNPs suggestively associated with food allergies and demonstrated genetic differences across phenotypes. It highlights the need for a unified food allergy definition.
A path to preventing cognitive impairment due to Alzheimer's disease: initiatives beginning in the USA - The Lancet Neurology www.thelancet.com/journals/lan...
Noncoding variants and sulcal patterns in congenital heart disease: Machine learning to predict functional impact: iScience www.cell.com/iscience/ful... supported by our office study explored relationship between predicted impact of ncDNVs and sulcal pattern features among participants with CHD.
www.nature.com/articles/s41.... Thoughtful article and worth a read.
Engineering chimeric antigen receptor CD4 T cells for Alzheimer’s disease | PNAS www.pnas.org/doi/10.1073/... 🧪
www.jci.org/articles/vie... 🧪. Great review evaluating the translational evidence of GLP-1RAs as candidate disease-modifying therapies for NDDs, including mechanistic pathways linking metabolic dysfunction to neuronal vulnerability, and outlining remaining challenges.
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www.nature.com/articles/s41...
Supported by our office this work
combines deep, convolutional neural network training to detect microneuromas with an uncertainty quantification mechanism that allows the model to communicate when it is unsure about a given image.
Preparing clinical research data for artificial intelligence readiness: insights from the National Institute of Diabetes and Digestive and Kidney Diseases data centric challenge url: academic.oup.com/jamia/articl... 🧪. happy to have supported the Data Centric Challenge
academic.oup.com/nar/article/.... 🧪. Supported by my office The Complex Portal (www.ebi.ac.uk/complexportal) (1) serves as a unifying resource, linking information on protein complexes across multiple resources by providing summaries of the molecular composition, topology (when known) and function
www.nature.com/articles/s41... in press release includes annotations and a detailed analysis of segmentations of diseased plants. Great resource
My linocut of Russian chemist Dmitri Mendeleev from shoulders up in a gradient of bright mint green at the bottom through navy to darkest blue-black at the top. He wears a suit with bow tie and a heavy bushy beard. The shape of the modern periodic table is carved into his chest as blank squares, and the elements he knew are indicated by their symbols. Those he included but not quite in the right place (because contemporary observations were still inconclusive) are indicated in pink). The blank squares were as-of-yet not discovered or isolated elements.
Happy birthday to Russian #chemist Dmitri Mendeleev (1834 – 1907) who published the periodic table. 🧪🐡 #histsci Born in Siberia, the youngest child of a large family, his father was a school principal until he lost his sight & job. His mother then restarted her family’s abandoned glass factory 🧵
www.sciencedirect.com/science/arti.... 🧪 tool to predict polypeptide helicity from amino acid sequence. Also training data available. Nice.
www.nature.com/articles/s41... 🧪. Impressive GWAS meta-analysis from the Anxiety Disorders Working Group of the Psychiatric Genomics Consortium
www.nature.com/articles/s41... 🧪. Exciting work on spatiotemporal modulation of Gs signaling
www.nature.com/articles/s41... 🧪. DeepMind AlphaGenome, trained on 1 Mb of DNA sequence from human and mouse and predicts thousands of functional genomic tracks including gene expression, transcription initiation, chromatin accessibility, histone modifications, transcription factor binding etc
link.springer.com/article/10.1... would like to see more on the implementation of the framework.
Temperature‐Dependent Chain Structures during Solution‐Grown Crystallization via Atomic Force Microscopy - Wang - Macromolecular Rapid Communications - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
🧪. Neat study of crystallization and polymer chain folding.
SAIGE-GPU — Accelerating Genome- and Phenome-Wide Association Studies using GPUs url: academic.oup.com/bioinformati... 🧪 really good news for biomedical researchers using NIH STRIDES clouds.
