Pauline Funchain

Good afternoon Vancouver 🌞🏔️ It’s 2026 and melanoma data continue to move in TIL 🏋️‍♀️

@drbetofmdphd.bsky.social discusses 10 year melanoma survival data for patients who have experienced complete response with earlier versions of TIL #MovingTheGoalPosts #CMC26 @stanford-cancer.bsky.social

New study: blood test using #cfDNA methylation detects multiorgan damage from immune checkpoint inhibitors — found in all patients with #irAE, sometimes weeks before symptoms. Suggests therapy causes systemic loss of immune tolerance. www.nejm.org/doi/full/10.... @funchainmd.bsky.social

Stanford #Melanoma’s @funchainmd.bsky.social leading us through a fantastic discussion of immune checkpoint toxicity #irAE in patients with pre-existing autoimmune disease. #CMC26 @stanforduniversity.bsky.social

Day 30 #NaGraWriMo: 15 (gra) ✅

Nov 2025 total: 557 mins writing 📝

Not 12 days of Christmas, but 30 days of November:

-5 pgs cut ✂️
-4 talks in 3 days 🎤
-2 manuscripts, 2 abstracts edited ✔️
-rainsoaked @scoutingamerica.bsky.social campout 🏕️
- @dodgers.com WS win 💍
and
-1 aims page 📃

#grateful

Day 29 #NaGraWriMo: 25 (gra) ✅

Nov 2025 total: 542 mins writing 📝

Today's insight: Cut 0.5 pg! Down to 7.5... Now in the cuts that hurt 😅😂

Day 28 #NaGraWriMo: 25 (gra) ✅

Nov 2025 total: 517 mins writing 📝

Today's insight: Black Friday changed the schedule but not the commitment. Day shopping and night writing ftw 🏆

Day 27 #NaGraWriMo: 27 (gra) ✅

Nov 2025 total: 492 mins writing 📝

Happy Thanksgiving! Grateful for the opportunity to write and represent @stanford-cancer.bsky.social 🦃

Also, totally unintentional numerology in writing 27 mins for the 27th day 🍀

Hugely impactful work addressing the toughest of diagnoses - leptomeningeal disease. Early trial discontinuation due to significant benefit of proton craniospinal irradiation (pCSI). Kudos to the authors including @drbetofmdphd.bsky.social @stanford-cancer.bsky.social

🙏🧠

Day 25 and 26 #NaGraWriMo: 10 (gra) and 15 (gra) ✅

Nov 2025 total: 465 mins writing 📝

Rounding the bases...3 more pages trimmed ✂️

Author's note: Did btw successfully cut over a page today! Excited to try again tomorrow 🥳

Day 24 #NaGraWriMo: 15 (gra) ✅

Nov 2025 total: 465 mins writing 📝

Today's insight: I tend to look at both forest and trees, which is a skill in and of itself but also is time consuming. If #NaMaGraMo has taught me anything, you don't (shouldn't) have to keep doing it the way you always have 🙏

Day 23 #NaGraWriMo: 15 (gra) ✅

Nov 2025 total: 440 mins writing 📝

3 weeks down, 1 to go! Challenging myself in the home stretch to cut 1 page per day to make the material fit the grant guidelines 😅🏋️

Day 21 and 22 #NaGraWriMo: 20 (ma) and 15 (ma) ✅

Nov 2025 total: 425 mins writing 📝

Today's insight: This is the first year I've had to double-day post regularly. Reflecting that as feedback (and grace) for exactly how challenging this year has been in comparison to the last 4 yrs I've done this 🕊️

Day 19 and 20 #NaGraWriMo: 25 (ma) and 15 (ma) ✅

Nov 2025 total: 390 mins writing 📝

2 more manuscript edits down 🥳

2/3 of November and #NaGraWriMo is in the books! 😅

Day 18 #NaGraWriMo: 20 (ma) ✅

Nov 2025 total: 350 mins writing 📝

Today's insight: As much as I want edits to take less time as I have more editing years under my belt, they still take a lot of time! On day 3 of what I thought would be 1 day of editing...

Day 17 #NaGraWriMo: 15 (ma) ✅

Nov 2025 total: 330 mins writing 📝

Today's insight: Oops transposed a day, so adding that day back to the total. Too tired for math, but not too tired to write! ✍️💪

Sign up now! 2026 ASPIRE-IOTOX Symposium at MDAnderson April 24-25, 2026. Join us to discuss #irAE! mdanderson.cloud-cme.com/course/cours... @funchainmd.bsky.social @kerryreynoldsmd.bsky.social @kmittalmd.bsky.social

🚨irAE aficionados - ASPIRE+ IOTOX CME 2026 - hosted by @mdanderson.bsky.social - open for registration! Abstract submission is also open 📝 Register below 👇
mdanderson.cloud-cme.com/course/cours...

Day 14 + 15 #NaGraWriMo: 50 (ma) ✅

Nov 2025 total: 290 mins writing 📝

Real talk - gave 4 talks in 3 days, followed by a rain soaked @scoutingamerica.bsky.social campout. I'm exhausted, happy, and should NEVER repeat a stretch like that again 🫠

Also HALFWAY DONE 🥳

Good morning Mountain View 🌞 Nothing like starting the day jumping into the great academic debate over surveillance strategies for uveal melanoma. Esp if one of the debaters is an old friend and colleague Arun Singh @clevelandclinic.bsky.social

Whatever it takes to knock out cancer 🥊 #rarediseases

Amazing night celebrating the inception of the Alan Adler Center for Ophthalmic Oncology and Prithvi Mruthyunjaya, the Alan Adler Professor of Ophthalmology @ Byers Eye and @stanford-cancer.bsky.social member 🍾🎊

Day 14 #NaGraWriMo: 25 (ma) ✅

Nov 2025 total: 265 mins writing 📝

Abstract edits ✅
Manuscript edits 1/2 way…

Two weeks down 🏋️‍♀️

Day 13 #NaGraWriMo: 15 (gra) ✅

Nov 2025 total: 240 mins writing 📝

Today's insight: Giving myself enough time to put away crucial pieces of writing (e.g. aims) and come back to them with fresh eyes, and repeating the process multiple times - I've had new thoughts each time #IterationWorks 🏆

Day 12 #NaGraWriMo: 15 (gra) ✅

Nov 2025 total: 225 mins writing 📝

Today's insight: Noise does matter... Tomorrow recommitting to writing before everyone else wakes up 😇

Abstract submissions for Spring Scientific are open through Jan. 15, 2026. Don’t miss this opportunity to share your research with your colleagues and fellow immuno-oncology professionals. Learn more about the program and register: https://sitcancer.org/edu/2026-spring-scientific

Day 11 #NaGraWriMo: 15 (gra) ✅

Nov 2025 total: 210 mins writing 📝

Today's insight: consistency is its own skill and reward (inspo from @dodgers.com, Yoshinobu Yamamoto, and Shohei Ohtani 💙)

Day 10 #NaGraWriMo: 15 (gra) + 25 mins (ma) ✅

Nov 2025 total: 195 mins writing 📝

Post vaccine recovery day (Day 9)...learned that sleeping in kills the writing for me. Up early today and punched it out 🌞 #BeginAgain #RealWorldWriting #MondayMotivation

Day 8 #NaGraWriMo: 15 mins (gra) ✅

Nov 2025 total: 155 mins writing 📝

Exhausted on a post vaccine day, but committed and completed 👊

Day 7 #NaGraWriMo: 15 mins (gra) ✅

Nov 2025 total: 140 mins writing 📝

Routine broke yesterday, but as they say in meditation circles, #BeginAgain 🌬️ Back on track! One week down! 💪

Day 5 & 6 #NaGraWriMo: 15 +15 mins (gra) ✅

Nov 2025 total: 125 mins writing 📝

Argh, forgot to post yesterday - living a life that I will appreciate for its fullness... 🙃