Manish Goel

Diagram of two types of reproduction based on their meiosis. A. shows typical meiosis taking place in individuals with two copies of each chromosome (diploids) resulting in both male and female gametes carrying one copy of each chromosome. Fertilization restores the double copy for each chromosome. B. shows Canina meiosis in individuals carrying five copies of each chromosome (pentaploids) where male gametes only carry one copy of each chromosome and female gametes carry four copies of each chromosome. Fertilization restores the five copy for each chromosome.

Check out the Views & News piece that Joiselle Fernandes and I wrote for @nature.com on the recent work from @amarques.bsky.social and colleagues about one of the most bizarre ways to do meiosis rdcu.be/euabu.

Explained for non-experts!

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🚨 My first PhD preprint is out on bioRxiv!
We show how tiny mutations—point mutations and kb-level indels—can shape the massive structure of Arabidopsis centromeres.
📄 Read it here: doi.org/10.1101/2025...
🧵 A short thread 👇

Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network - Nature Communications Over time, paralogous genes accumulate changes in their sequences that do not affect their function, which is called cryptic variation. Using paralogous myosins, this study shows how cryptic variation...

How does cryptic genetic variation influence the long-term fate of gene duplicates (paralogs)?
Our new study addresses this question by dissecting the evolutionary potential of redundant myosin paralogs in yeast nature.com/articles/s41... (1/12)

It's okay the gap penalty score is 0.

What a trove of potato genomes reveals about the humble spud Hear the biggest stories from the world of science | 16 April 2025

This week on the pod:

🥔 A potato pangenome
📄 The top cited twenty-first century research papers
https://go.nature.com/4j9z50Z

The phased pan-genome of tetraploid European potato - Nature A haplotype-resolved pan-genome of autotetraploid European potato founder lines shows high nucleotide diversity at remarkably low haplotype diversity, which is probably the result of hybridization eve...

📢 Excited to share our work out now in @nature.com! 📢

We present the phased pan-genome of tetraploid European potato, based on 10 historical cultivars representing 85% of European potato diversity.

Learn more below!

🔗 www.nature.com/articles/s41...

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PhDs are paid positions, enough to live comfortably even in a big city like Vienna, and include all health insurance, social benefits, pension contributions. Usually with low to no teaching requirements (but opportunities to get involved if interested!). Main focus is your research.

Perhaps if helps at this point to outline how the academic path works outside the US. I can speak for Austria, but many EU countries are similar. Students usually do a BSc (3 yrs) then an MSc (2 yrs) then apply for PhD positions (range 3-5 yrs, average around 4).

I worked in Max-Planck Institute for seven years and loved every day of it. For anyone getting affected by the current changes, I can strongly recommend @maxplanck.de

@maxplanck.de President @patrick-cramer.bsky.social is on it already.

www.spiegel.de/wissenschaft...

I would assume that the students and research employees are paid using 85% direct costs. Only the administrative employees would need to be paid from the indirect costs.

Is it the case that these indirect rates are the major source of funding for the institutions? I would have assumed that they receive separate funding by the government for maintaining the facility which then also controls administrative costs.

My initial thought (as non american) is that 15% for administration and 85% for direct project related expenses seems to be a good ratio, but I assume I am missing something. I would be happy to know more.

Bluesky’s science takeover: 70% of Nature poll respondents use platform Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X.

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X

https://go.nature.com/42tH8Ai

Credits: FIDE - https://flic.kr/p/2qCjP8a

Congratulations to Koneru Humpy for winning the FIDE Women's World Rapid Chess Championship 2024 - for the second time after 2019! 🎉 https://lichess.org/broadcast/fide-world-rapid--blitz-championships-2024--rapid-women/round-11/0eCc1imU/sJNJUFmi

Other than entangling, could there be other issues that make them not work? 🤔

High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
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Imo, Faster RAM, better Networking == Redbull for cluster.

Overview of Bio-xLSTM

Conditional generation of molecules via ICL and 15M parameter model

Generative pre-training of protein language models

Long-context xLSTM models of DNA, proteins, and chemicals.
@smdrnks.bsky.social @phseidl.bsky.social @gklambauer.bsky.social

arxiv.org/abs/2411.04165