When RNA Degradation ๐ค meets ๐ค Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).
Check out the newest preprint from the Schulman lab ๐๐
Super cool mechanism of how a metabolite regulates the stability of its own metabolizing enzyme!
Alina did it all for this project CRISPR screen โ๏ธ, biochemistry ๐งช, and cryo-EM โ๏ธ๐ฌ.
Congrats!
New research group leader @matthiasmuhar.bsky.social joins @mpi-cbg.de! ๐ฅณ With his group "Functional genomics of proteome remodeling,โ Matthias wants to pursue high-throughput genetic studies to understand how protein turnover is regulated. Welcome, Matthias! www.mpi-cbg.de/news-outreac...
What controls expansion & contraction of DNA repeats (e.g. Huntington's)? We were thrilled to collaborate w/ the lab of Marta Olejniczak to find out. Check out the cool screen from @sebasiegner.bsky.social and @matthiasmuhar.bsky.social that reads out repeat sequence. www.biorxiv.org/content/10.1...
On that note: hello world! My new lab on genetics of proteome remodeling is starting at the incredible MPI-CBG. We have big plans and open positions for PhD students and an RA. Apply now (!) at imprs.mpi-cbg.de and tinyurl.com/2vywj6f6 respectively.
Fascinated by protein homeostasis, stem cells and development? I am recruiting PhD candidates through the fabulous IMPRS-CellDevoSys program. This place is buzzing with great science and brilliant minds. Come join!
โกโกExcited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
๐ฌ๐ฆ I'm hiring at all levels! ๐ฌ๐ฆ Check: www.molgen.mpg.de/fueyo-lab
Are you interested in a PhD in the area of "Mechanisms of translational control during embryogenesis?" Apply now for a PhD @mpi-cbg.de! Overview of all participating RGLs: imprs.mpi-cbg.de/5761/researc...
Heads up: ignore samtools dot org, similarly minimap2 dot com and likely others. It's owned by a known phishing site and while the binaries they offer look valid currently (but note they may be serving us different binaries to others), that could change.
Ie: it's not us (Samtools team)! Be warned
Looks like private funders, HHMI,CZI etc., are not going to โsaveโ US research. Europe is setting up mechanisms to attract US researchers & it may work. But, common, target junior talent, donโt shower money on superstars who will be flying professors & return to US when the science winter passes.
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
๐ข Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details โก๏ธ tinyurl.com/3fbkp89c
Weโre sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible with individual and combinatorial perturbations, diverse SpCas9-based technologies, and multiple high-content, single-cell readouts. www.biorxiv.org/content/10.1...
Planning to apply for #research #funding from the ERC?
From the next application rounds, expect changes to the:
โข proposal structure
โข evaluation process
โข extra funding you can request
โข eligibility for Starting & Consolidator #Grants (from 2027)
More ๐ europa.eu/!RPHWvv
Super excited to share our latest work on deciphering the #Ubiquitin Code
โ๐จ๐ฏ๐ถ๐ฅ๐๐๐ ๐ฑ๐ฒ๐ฐ๐ถ๐ฝ๐ต๐ฒ๐ฟ๐ ๐ฝ๐ฟ๐ผ๐๐ฒ๐ฎ๐๐ผ๐บ๐ฎ๐น ๐ฑ๐ฒ๐ด๐ฟ๐ฎ๐ฑ๐ฎ๐๐ถ๐ผ๐ป ๐ฐ๐ผ๐ฑ๐ฒ ๐ผ๐ณ ๐ต๐ผ๐บ๐ผ๐๐๐ฝ๐ถ๐ฐ ๐ฎ๐ป๐ฑ ๐ฏ๐ฟ๐ฎ๐ป๐ฐ๐ต๐ฒ๐ฑ ๐48 ๐ฎ๐ป๐ฑ ๐63 ๐๐ฏ๐ถ๐พ๐๐ถ๐๐ถ๐ป ๐ฐ๐ต๐ฎ๐ถ๐ป๐โ
@cp-molcell.bsky.social
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www.cell.com/molecular-ce...
We will very soon seek to fill several positions for starting Principal Investigators with highly competitive startup packages, recruiting both for AI/ML and Life Sciences. Please spread the word and help us find the best candidates. Watch this space (us) as many exciting news will be announced.
๐Super excited to share our story on how the substrate receptor FBXO31 functions as a quality control factor by recognizing amides. This has been an amazing collaboration between Bode lab and @jcornlab.bsky.social. Special shutout goes to @matthiasmuhar.bsky.social www.nature.com/articles/s41...
