Vijay G. Sankaran

Congratulations, @paralkarlab.bsky.social!!!

🙏 🙏 @samhegde.bsky.social!!

Fantastic talk at #KSHemato26 from @gaoteng.bsky.social on our recent advances in mitochondrial 🧬 lineage tracing!

Please check out the preprint: www.biorxiv.org/content/10.6...

Join us in congratulating the award winners from the National Heart, Lung, and Blood Institute, @niaidnews.bsky.social, and the Keystone Symposia Future of Science Fund at #KSHemato26 in Keystone! 👏

#FutureofScience #hematopoiesis #bonemarrow
@bloodgenes.bsky.social @beaudinlab.bsky.social

Check out this fascinating MPRA in human hematopoietic cells from Satish Nandakumar, @tewhey.bsky.social, and team!! www.biorxiv.org/content/10.6...

Paediatricians’ blood used to make new treatments for RSV and colds Antibodies harvested from the blood of paediatricians are up to 25 times better at protecting against the common respiratory infection RSV than existing antibody therapies, and are now being developed as preventative treatments

Antibodies harvested from the blood of paediatricians are up to 25 times better at protecting against the common respiratory infection RSV than existing antibody therapies, and are now being developed as preventative treatments

The $100 whole human genome sequence finally reached!
www.sandiegouniontribune.com/2026/02/19/s...

Fascinating article by the insightful @jasonmast.bsky.social!! Maybe 🩸 stem cell expansion could help?: www.nature.com/articles/s41...

Exciting clinical study in @nejm.org from Cherqui Lab @ucsdhealth.bsky.social showing how 🩸 stem cell 🧬 therapy can treat cystinosis, a lysosomal metabolic disorder! Expanding the scope of 🩸🧬 tx! www.nejm.org/doi/full/10....

Fascinating paper in @nature.com today about how 🧬 variant impacting cyclin D3 alters malaria infectivity of red cells! www.nature.com/articles/s41..., www.nature.com/articles/d41... ... Follows up on some of our original studies from over 14 years ago: genesdev.cshlp.org/content/26/1...

Check out this important advance in mitochondrial 🧬 lineage tracing by @gaoteng.bsky.social and @wengchen.bsky.social from our group, in collaboration with @jswlab.bsky.social 👇👇

@biorxivpreprint.bsky.social Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans
www.biorxiv.org/content/10.6... @bloodgenes.bsky.social @jswlab.bsky.social @bostonchildrens.bsky.social @hhmi-science.bsky.social @broadinstitute.org

🙏 🙏

Really grateful to all the wonderful folks at @yalecancer.bsky.social for hosting me, particularly @halenelab.bsky.social!! 🙏 🙏

Congratulations, @smckinneyfreeman.bsky.social!!!

CD19 CAR T-Cell Therapy for Autoimmune Hemolytic Anemia | NEJM In patients with autoimmune hemolytic anemia (AIHA), the risk of relapse is high owing to persistent autoreactive B-cell activity. Multirefractory AIHA is a more advanced stage of disease that is d...

Another major triumph for a refractory autoimmune disease—hemolytic anemia—through engineered T cells
@nejm.org
nejm.org/doi/full/10....

A Genetic Brake on Blood Cancer Risk A large genetic analysis uncovered a variant that restrains clonal hematopoiesis by slowing the growth of mutated blood stem cells linked to myeloid malignancies. The mechanisms involved may offer tar...

Thank you to @aacrjournals.bsky.social and Elie Dolgin for this wonderful piece covering our work! Features great insights from Danielle Hammond & Lachelle Weeks: aacrjournals.org/cdnews/news/...

Enjoyed writing this Preview with Jonas Gudera on GoT-Multi 🪄
A powerful #singlecell approach from the teams of Anna Nam and @lgmartelotto.bsky.social

Preview: www.cell.com/cell-genomic...

Paper: www.cell.com/cell-genomic...

Congratulations, @raflynn5.bsky.social!!!

Congratulations, @lucas.farnunglab.com!!

Congratulations, @tomonroe.bsky.social!!!

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits Gene regulatory networks encode the fundamental logic of cellular functions, but systematic network mapping remains challenging, especially in cell states relevant to human biology and disease. Here, ...

Together with @ronghuizhu.bsky.social, we are thrilled to present our new perturb-seq study of 22M primary CD4+ T cells, across donors and timepoints – the result of a decade-long collaboration between the Marson @marsonlab.bsky.social and Pritchard @jkpritch.bsky.social labs 🧵 tinyurl.com/gwt2025

Interested in #hematopoiesis 🩸? Please join us at the @keystonesymposia.bsky.social Hematopoiesis meeting with an amazing lineup (only some of whom are shown) this February! Poster Abstracts due by February 3rd. #KSHemato26 keysym.us/KSHemato26

Congratulations, @dimiccolab.bsky.social, Serena, @stephxie.bsky.social, and team!!!

Dysregulated activation responses is a defining feature of HSPC aging and establish proliferative stress–based xenotransplantation is a powerful platform for investigating age-related hematopoietic dysfunctions
@jem.org @dimiccolab.bsky.social
rupress.org/jem/article-...

Thank you so much, @trevorgraham.bsky.social!! Interestingly, variant is found across populations, but has been maintained at low percentage frequencies. More work to do 🙏

Finally, the most rewarding part of my job is watching trainees grow. @g-agarwal.bsky.social first came to the lab in 2017 when he was an Oxford medical student. Then he came back a few years later. It has been incredible to see his ⬆️ trajectory. For 🩸folks, keep your 👀 on him! (fin)

Genetic variant appears to protect some people against certain blood cancers Researchers found a genetic variant that appears to protect against the development of CHIP, a phenomenon that can lead to certain blood cancers

And nice coverage by @angusrohan.bsky.social from @statnews.com (3/n): www.statnews.com/2026/01/01/b...

Genetic resistance to leukemia A genome-wide association study identifies a genetic variant that reduces the risk of leukemia

Please check out this terrific preview from Caido & Manz (2/n): www.science.org/doi/10.1126/...

Delighted to have our work on 🧬 resilience to 🩸cancer led by @g-agarwal.bsky.social & amazing collaborators, including @kharaslab.bsky.social, published in @science.org: www.science.org/doi/10.1126/... 🧵