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Alexei Maklakov

@alexeimaklakov

Biology of Ageing and Life History Evolution, University of East Anglia, Norwich, UK

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24.10.2023
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Latest posts by Alexei Maklakov @alexeimaklakov

It was great to host @jpsenescence.bsky.social over a couple of days @biouea.bsky.social, great seminar on the new approaches to the old problem of ageing )

27.02.2026 18:39 πŸ‘ 15 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Great Revolution at @animecol-uu.bsky.social : thank you for inviting me, fun to be on the other side of the barricades this time πŸ˜€

15.02.2026 14:59 πŸ‘ 6 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Do natural substances from blueberries and blue grapes protect nerve cells from aging? Using an aging clock, researchers from the University of Cologne have used the Caenorhabditis elegans model organism to demonstrate that nerve cells age differently. They identified both the cause ...

Do natural substances from blueberries and blue grapes protect nerve cells from aging?A www.bionity.com/en/news/1188...

07.02.2026 11:02 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 1
UK science policy in transition – Soft Machines, by Richard Jones

The way UK govt funds science is in the midst of a major transition, with creation of a much more direct link between government priorities & UKRI research funding.

My attempt to set in context the biggest upheaval in UK science funding policy since the 1980s:
softmachines.org?p=3252

06.02.2026 08:48 πŸ‘ 26 πŸ” 21 πŸ’¬ 2 πŸ“Œ 7
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Aging clocks delineate neuron types vulnerable or resilient to neurodegeneration and identify neuroprotective interventions - Nature Aging Gallrein et al. pair functional assays with clocks to compare chronological versus biological age of single neuron types in C. elegans, to probe their vulnerability or resilience to neurodegeneration,...

🧠⏰our latest paper is out now: how each neuron ages differently allowed us to define in silico screens for new therapeutic molecules that could prevent neurodegeneration @cecad.bsky.social @unicologne.bsky.social @uniklinikkoeln.bsky.social @meyerdh.bsky.social www.nature.com/articles/s43...

03.02.2026 11:44 πŸ‘ 10 πŸ” 7 πŸ’¬ 2 πŸ“Œ 0

And @meyerdh.bsky.social πŸ˜€

03.02.2026 21:12 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Congrats BjΓΆrn!

03.02.2026 21:11 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Experimental Evidence That Prenatal and Postnatal Developmental Stress Affects the Adult Seminal Fluid Proteome in a Precocial Bird Seminal fluid proteins are important modulators of male fertility and reproductive success, yet little is known about how their abundance responds to early-life developmental stress. Japanese quail C...

How does pre- and post-natal environmental stress affect the seminal foam proteome of Japanese quail? Find out here, Chloe Mason’s second PhD thesis paper: onlinelibrary.wiley.com/doi/10.1111/... @martingarlovsky.bsky.social @oscarvedder.bsky.social

01.02.2026 10:06 πŸ‘ 14 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0

The bots populating Moltbook apparently all come to sound like a familiar kind of internet denizen with delusions of philosophical grandeur. Manifestos and declarations all over the place.

31.01.2026 13:01 πŸ‘ 155 πŸ” 32 πŸ’¬ 12 πŸ“Œ 3
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DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality
www.science.org/doi/10.1126/...
@science.org @idikic.bsky.social @goetheuni.bsky.social

29.01.2026 22:38 πŸ‘ 6 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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The largest randomized trial of medical A.I.
β€”Over 100,000 women in Sweden
β€”radiologist + AI vs 2 radiologists, in follow-up
β€”AI added led to 29% more cancer detected, 44% reduced workload, and
β€”Less cancer dx in subsequent 2 years, and, when found, less aggressive
thelancet.com/journals/lan...

29.01.2026 23:47 πŸ‘ 298 πŸ” 93 πŸ’¬ 11 πŸ“Œ 17
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πŸ†• @science.org
Revising the heritability of lifespan, from 25% to ~50%, by correcting for extrinsic factors
science.org/doi/10.1126/...

29.01.2026 19:04 πŸ‘ 99 πŸ” 18 πŸ’¬ 5 πŸ“Œ 8

Thanks to some great comments and suggestions, we've updated TADA!

Read it here: ecoevorxiv.org/repository/v...

Transferable, Available, Documented, Annotated.

28.01.2026 08:20 πŸ‘ 14 πŸ” 11 πŸ’¬ 1 πŸ“Œ 0
TADA! Simple guidelines to improve code sharing

πŸŽ‰New preprint!

"TADA! Simple guidelines to improve code sharing"

tinyurl.com/8rmnwjrk

We present simple guidelines to help researchers of all coding levels improve the transparency and reproducibility of their analytical code, TADA!

Transferable, Accessible, Documented, Annotated.

02.08.2025 17:05 πŸ‘ 100 πŸ” 53 πŸ’¬ 2 πŸ“Œ 5
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Friends! I am so happy to share our new preprint!

Hydrogen peroxide has been the most common reactive chemical threat to life forms since the Great Oxygenation Event 2.5 billion years ago.

How do animals like C. elegans sense it fast and escape?

www.biorxiv.org/content/10.6...

Thread 1/

28.01.2026 15:13 πŸ‘ 81 πŸ” 31 πŸ’¬ 7 πŸ“Œ 3
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Join Join Society for Open, Reliable, and Transparent Ecology and Evolutionary biology (SORTEE)

Just renewed my membership for the 5th year with @sortee.bsky.social.

A fantastic organisation to be a part of. If you want to become a member and are interested in open, reliable, and transparent EcoEvo, it’s worth joining!

sortee.org/join/

23.01.2026 08:48 πŸ‘ 10 πŸ” 3 πŸ’¬ 1 πŸ“Œ 1
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Finding an em dash in the rejection email

22.01.2026 17:52 πŸ‘ 53 πŸ” 3 πŸ’¬ 4 πŸ“Œ 0
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Predatory aggression evolved through adaptations to noradrenergic circuits - Nature Noradrenergic circuits support and balance aggressive behavioural states in predatory nematodes, distinguish predatory from non-predatory nematode species and are associated with the evolution of comp...

Why do some worms graze on bacteria while others hunt and kill?
Our study, published today in Nature, reveals how predatory aggression evolved in nematodes.
Led by @gunizgozeeren.bsky.social and @leoboeger.bsky.social across the @jameslightfoot.bsky.social and @monikakscholz.bsky.social labs.

21.01.2026 16:31 πŸ‘ 80 πŸ” 35 πŸ’¬ 9 πŸ“Œ 5
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Disease tolerance and infection pathogenesis age-related tradeoffs in mice - Nature Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease tolerance genes show antagonistic pleiotropy.

Nature research paper: Disease tolerance and infection pathogenesis age-related tradeoffs in mice
go.nature.com/4pBODwV

19.01.2026 18:36 πŸ‘ 14 πŸ” 2 πŸ’¬ 0 πŸ“Œ 1

Hot off the press! New paper in Biology Letters (@royalsocietypublishing.org) showing that heatwaves impair female but not male fertility in burying beetles 🐞🌑️

Huge congratulations to Izzy (@izzygrieve.bsky.social) on her first first-authored paper! πŸ₯³πŸ™Œ

royalsocietypublishing.org/rsbl/article...

19.01.2026 14:02 πŸ‘ 23 πŸ” 10 πŸ’¬ 1 πŸ“Œ 0
Flexible use of a multi-purpose tool by a cow
Flexible use of a multi-purpose tool by a cow YouTube video by Antonio Jose Osuna MascarΓ³

youtu.be/bAk4PFEuWKQ?...

19.01.2026 19:09 πŸ‘ 7 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Meet Veronika, the tool-using cow Veronika uses sticks to scratch herself, suggesting scientists have underestimated cow cognition...

Meet Veronika, the tool-using cow. Veronika uses sticks to scratch herself, using different orientations and motions, an example of multi-purpose tool use. This suggests scientists may have underestimated cows' cognitive abilities. arstechnica.com/science/2026...

19.01.2026 16:51 πŸ‘ 139 πŸ” 35 πŸ’¬ 4 πŸ“Œ 18
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Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line Early life stresses impact reproductive outcomes in many organisms. In response to crowding and starvation, C. elegans nematodes form dauer larvae, in which development arrests until conditions improv...

Pre-dauer starvation rapidly and reversibly reduces niche proliferative signaling to the C. elegans germ line

journals.biologists.com/dev/article/...

18.01.2026 21:44 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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The (Yoav) Voichek lab has opened its gates at the Weizmann Institute, and is actively recruiting students and researchers at all levels - come explore gene regulation and computational genomics in a fun, friendly sprouting lab πŸ€—πŸ₯Όβš—️πŸ§ͺ
www.weizmann.ac.il/plants/voichek

11.01.2026 20:41 πŸ‘ 44 πŸ” 32 πŸ’¬ 0 πŸ“Œ 0
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Long COVID involves activation of proinflammatory and immune exhaustion pathways - Nature Immunology Long COVID (LC) involves a spectrum of chronic symptoms after resolution of acute severe acute respiratory syndrome coronavirus 2 infection. Barouch and colleagues show that LC is characterized by per...

Hoping the pivotal finding of increased inflammation with #LongCovid will be responsive to tirzepatide (Zepbound) in our ongoing 1,000+ participant randomized, placebo-controlled trial (full enrollment completed in <1 month!)
www.nature.com/articles/s41... @natimmunol.nature.com

04.01.2026 17:16 πŸ‘ 288 πŸ” 67 πŸ’¬ 3 πŸ“Œ 1
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A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine - Scientific Reports Scientific Reports - A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine

A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine
www.nature.com/articles/s41...

28.12.2025 20:19 πŸ‘ 1 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Picture of a Christmas tree shaped from laboratory equipment, molecules, viruses and atoms.
Copyright: Anna Zhuravlova

Picture of a Christmas tree shaped from laboratory equipment, molecules, viruses and atoms. Copyright: Anna Zhuravlova

Merry Christmas, Happy Holidays and a Peaceful New Year from everyone in the School of Biological Sciences.
Have a wonderful break. πŸŽ„πŸ₯³

23.12.2025 10:27 πŸ‘ 8 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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The one validated intervention to slow aging and extend healthspan is not for sale.
It's exercise.
sciencedirect.com/science/arti...

20.12.2025 18:22 πŸ‘ 373 πŸ” 123 πŸ’¬ 7 πŸ“Œ 10

Excellent news!!!

17.12.2025 13:05 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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What tools do we need to start engineering #aging and #longevity ? A🧡about something we've been cooking up in lab with Jeremy Vicencio at the @crg.eu : technology that lets us reach inside living animals and precisely dial multiple proteins' levels up and down. 1/10

16.12.2025 12:09 πŸ‘ 22 πŸ” 10 πŸ’¬ 3 πŸ“Œ 2