The Fromm Lab's Avatar

The Fromm Lab

@frommlab

lab at @UiTNorgesarktis studying microRNAs, paleotranscriptomics, biosystematics with a fable for flatworms. MirGeneDB, MirMachine, MirMiner (soon!)

1,267
Followers
2,513
Following
199
Posts
10.11.2023
Joined
Posts Following

Latest posts by The Fromm Lab @frommlab

Preview
Accessory microRNA byproducts expand RNA interference via microprocessor-mediated cleavage activation Insights into microRNA processing guide the design of an RNA medicine strategy that enables precise multitargeting against cancer.

Curious paper!

„Accessory microRNA byproducts expand RNA interference via microprocessor-mediated cleavage activation“

I was thinking offset reads first, but this does not look like it? Thoughts?

www.science.org/doi/10.1126/...

02.03.2026 22:24 👍 1 🔁 0 💬 1 📌 0

One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link: nyti.ms/4qMbo22

18.02.2026 19:12 👍 70 🔁 25 💬 0 📌 1
What a Gene Regulatory Network Is — and What It Is Not ! - the Node Pedro Martinez. Departament de Genètica, Microbiologia i Estadística, Universitat de Barcelona Gene Regulatory Networks: An Introduction and Their

Trying to sort out a vexing issue:

What a Gene Regulatory Network Is — and What It Is Not ! thenode.biologists.com/what-a-gene-...

13.01.2026 10:50 👍 3 🔁 1 💬 0 📌 0

See who is back!! @pedromartinezserra.bsky.social

16.02.2026 16:59 👍 3 🔁 0 💬 0 📌 0
Separable roles for Microprocessor and its cofactors, ERH and SAFB1/2, during microRNA cluster assistance A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

new paper from the Lai lab! Renfu Shang performs careful mechanistic dissection of miRNA cluster assistance and reveals many insights and surprises to this enigmatic regulatory strategy that gives suboptimal miRNAs a boost. if you love Northerns, you'll ♥️ this! 🧬

genesdev.cshlp.org/content/earl...

23.01.2026 20:21 👍 26 🔁 11 💬 1 📌 0
Biochemical principles of miRNA targeting in flies - Nature Communications MicroRNAs guide Argonaute proteins to repress gene expression. Here, the authors define the binding rules for five Drosophila miRNAs, showing a narrow preference for canonical seed sites and identifyi...

Happy to see our study out! We define the sequence determinants for miRNA-target interactions in flies and provide a foundation for improving computational prediction of miRNA-mediated regulation in Drosophila.
www.nature.com/articles/s41...
#miRNA, @natcomms.nature.com, @rti-umasschan.bsky.social

06.02.2026 07:32 👍 12 🔁 5 💬 0 📌 0
Preview
A parasitic wasp suppresses host pupation by microRNA‐mediated transcriptional silencing of OfE93 Parasitism by Macrocentrus cingulum induces miR-281a-5p upregulation in the host Ostrinia furnacalis larvae, which suppresses OfE93 expression and arrests pupation. This finding reveals a miRNA-media...

A #parasitic wasp suppresses host pupation by #microRNA-mediated transcriptional silencing of OfE93
onlinelibrary.wiley.com/doi/10.1111/...

27.01.2026 13:14 👍 3 🔁 1 💬 0 📌 0
Preview
Symbiotic entrenchment through ecological Catch-22 A symbiotic rove beetle develops a stealth phenotype by silencing production of its hydrocarbon pheromones, enabling it to infiltrate ant colonies, steal ant pheromones, and achieve social acceptance ...

Symbiotic (and genomic) entrenchment!
www.cell.com/cell/abstrac...

07.02.2026 09:46 👍 4 🔁 0 💬 0 📌 0
Preview
Science journals retract 500 papers a month. This is why it matters A small team of volunteers is tracking thousands of falsified studies, including cases of bribery, fraud and plagiarism

‘Science journals retract 500 papers a month. This is why it matters.
A small team of volunteers is tracking thousands of falsified studies, including cases of bribery, fraud and plagiarism’

Ivan Oransky @retractionwatch.com, @alicedreger.bsky.social @thetimes.com

www.thetimes.com/uk/science/a...

19.01.2026 17:35 👍 103 🔁 38 💬 1 📌 0

For the model species for sure!!

16.01.2026 16:23 👍 1 🔁 0 💬 0 📌 0
Poster of the EM course in Naples with marine samples. The Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples arises from a very strong and active collaboration between the Stazione Zoologica Anton Dohrn and the EMBL in Heidelberg.
The aim of the course is to provide a theoretical and practical training on electron microscopy starting from the basics to the preparation of samples with high pressure freezing and image acquisition using TEM and SEM.

Poster of the EM course in Naples with marine samples. The Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples arises from a very strong and active collaboration between the Stazione Zoologica Anton Dohrn and the EMBL in Heidelberg. The aim of the course is to provide a theoretical and practical training on electron microscopy starting from the basics to the preparation of samples with high pressure freezing and image acquisition using TEM and SEM.

If you are interested in electron microscopy, registration is still open for the

"Electron Microscopy Hands-On Course: sample preparation and imaging of marine environmental samples"

at Stazione Zoologica in Naples.

WIth great teachers from Naples […]

[Original post on biologists.social]

13.01.2026 07:07 👍 31 🔁 32 💬 0 📌 1
Post image

Wow! 167.2 Gb HiFi yield from a PacBio SMRT cell🎉 Are we getting close the record? This run was for the “Genome of Sweden” project, where we're building a national reference dataset from 10 year old biobanked DNA samples🧬🧪

12.01.2026 09:54 👍 12 🔁 3 💬 0 📌 0
Preview
CarpeDeam: a de novo metagenome assembler for heavily damaged ancient datasets - Genome Biology De novo assembly of ancient metagenomic datasets is a challenging task. Ultra-short fragment size and characteristic postmortem damage patterns of sequenced ancient DNA molecules leave current tools…

Dreaming of a de novo assembly of your pesky short ancient sequences? 🧬 A new tool, CarpeDeam, may just help your dreams come true. 🧬🖥️
link.springer.com/article/10.1...
#MetagenomicsMonday #ancientDNA #aDNA #paleogenomics #bioinformatics

12.01.2026 08:01 👍 7 🔁 4 💬 0 📌 1

cool Oleks! Have you tested what those ultra conserved loci are?

09.01.2026 08:27 👍 0 🔁 0 💬 0 📌 0

!!!

22.12.2025 10:49 👍 7 🔁 1 💬 0 📌 0

I can only second this. BUT, what people often are not aware of: Frontiers in Zoology does NOT belong to the rest of the Frontiers in journals. It is the official journal of the German Zoological Society, a BMC journal and founded BEFORE the other Front in. We suffer a lot from this hijacking.

21.12.2025 13:50 👍 14 🔁 5 💬 1 📌 0
Validate User

Latest RNAcentral update out!
academic.oup.com/nar/advance-...

21.12.2025 13:05 👍 1 🔁 0 💬 0 📌 0
Post image

Permanent Research Group Leader Position, Crete, Greece: Interested to assume long-term responsibilities for the Biodiversity Computing Group www.biocomp.gr I have set up in Crete? Apply now via apella.minedu.gov.gr/en/node/5998 (PDF also in English) - for questions email to stamatak@ics.forth.gr

15.12.2025 07:23 👍 20 🔁 31 💬 0 📌 0
Post image Post image Post image

Awesome two day course on microRNA annotation and differential expression analysis done in Oslo last week (#OsloBioinformaticsweek2025) done.

Participants (and tutors!) were so committed that this turned out a microRNA hackathon and we are drafting a paper!!!!

Thanks for the invite!!

14.12.2025 11:46 👍 5 🔁 1 💬 0 📌 0

Check RNA, DNA and disease (separately)

12.12.2025 16:28 👍 1 🔁 0 💬 0 📌 0

so what is it??

12.12.2025 15:45 👍 0 🔁 0 💬 1 📌 0

Peracarid crustaceans contain multitudes - at least 26000 species. In the open ocean, some have transparent eyes up to half the body size (they see more contrast but less precision). In caves, they lose eyes and enhance their smell processing.

Papers next #Crustmas 🧪🦑

10.12.2024 16:37 👍 88 🔁 16 💬 5 📌 4
Post image

Two days of teaching everything about microRNAs in Oslo (#OsloBioinformaticsWeek) ahead.

08.12.2025 10:03 👍 7 🔁 0 💬 1 📌 0

WOW❗🤯

The amount and quality of the abstracts we've received have completely blown us away! More than 300 abstracts from researchers at all levels and from 33 countries.

We will communicate the selected talks and open registration soon 👉 icp2026.palaeogenomics.org

#ICP2026 will be UNMISSABLE 😍💪

02.12.2025 09:52 👍 22 🔁 7 💬 1 📌 0

@projectpsyche.bsky.social is there a way to get samples of Morpho from you?

26.11.2025 10:31 👍 2 🔁 0 💬 0 📌 0
Preview
Oslo Bioinformatics Workshop Week 2025 - Bioinformatics in Life Science – BiLS December 8th-12th 2025 will see the fourth edition of the Oslo Bioinformatics Workshop Week at the University of Oslo, Norway. This event is organised by the Trainee Committee of BiLS (Bioinformatics ...

The course is aimed at all levels of researchers with projects and interest in microRNAs and free of charge.
Signup here:

www.mn.uio.no/bils/english...

#check also all the other great courses!! 2/2

25.11.2025 10:37 👍 3 🔁 1 💬 0 📌 0

#FREECOURSE-announcement
Want to learn about microRNA annotation and differential expression analyses? Within the Oslo Bioinformatics week 2025, we will be teaching a two-day course on the 9th and 10th of December at the University of Oslo. 1/2

25.11.2025 10:37 👍 6 🔁 2 💬 1 📌 1
Video thumbnail

Ever seen priapulids?

24.11.2025 18:33 👍 2 🔁 1 💬 0 📌 0
Preview
Revised evolutionary relationships within Brachycera and the early origin of bicoid in flies Mulhair et al. uncover a functional bicoid in non-cyclorrhaphan flies, pushing the gene's origin back by ∼20 million years. Reassessing the Diptera phylogeny using the largest dataset to date permits ...

Latest work out today in @currentbiology.bsky.social

We find the fly development gene bicoid is much older than previously thought (~20 million yrs older!) 🪰🧬

To pinpoint its origins we tackled the Diptera phylogeny, providing some resolution (many open questions remain).

🔗 tinyurl.com/2vyuevpy

17.10.2025 15:13 👍 92 🔁 44 💬 6 📌 4
Preview
Adenine DNA methylation associated with transcriptionally permissive chromatin is widespread across eukaryotes - Nature Genetics Long-read sequencing in 18 unicellular eukaryotes reveals that 6mA is widespread across eukaryotes and is enriched at transcriptionally permissive regions, which are also marked by H3K4me3.

Out today, our take on 6-methyladenine #6mA evolution in Eukaryotes @natgenet.nature.com. We asked a simple question, is really DNA 6mA common across the eukaryotes? The answer is "yes" if you're a unicellular eukaryote 🦠, not so if you're multicellular 🐝🌱🍄. www.nature.com/articles/s41... 1/9

18.11.2025 12:00 👍 164 🔁 85 💬 7 📌 6