Professor Jamie Spangler has been awarded the 2025 President’s Frontier Award for her groundbreaking work in molecular immunoengineering. Her pioneering research is shaping the future of therapies for cancer, autoimmune diseases, and more. https://bit.ly/4pMVsfo
'Build something complex in a domain where you are already an expert and iterate on it' is a much more sophisticated and realistic message than 'AI will do all the work so we won't need experts at all'.
What the KENNEDY Center used to be…
Remember that time Aretha Franklin performed at the 2015 Kennedy Center Honors, paying tribute to Carole King, who co-wrote “You Make Me Feel Like A Natural Woman,” and it brought a tear to Obama’s eye and everyone to their feet? And Carole King’s reaction. Wow.
What maintains ILC2s in airway allergy? We report a complement-producing stromal niche forming an IL-33 alarmin hub sustaining ILC2s.
Thanks to the JHU Catalyst Award for the support!!
cc @deniswirtz.bsky.social @cp-cellreports.bsky.social @hopkinsmedicine.bsky.social
www.cell.com/cell-reports...
Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
@mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
I just loved this and thought I’d share. 🙏
I started my blog post 16 years ago!
It's really amazing that I can keep it :)
Introducing gRNAde: our own little "AlphaGo Moment" for RNA design! 🧬🚀
📝: tinyurl.com/gRNAde-paper
Unlike proteins, RNA design has long relied on "wisdom of the crowd" (human experts) or the slow crawl of directed evolution — gRNAde changes that! 🧵👇
Two scientists who are fast friends, one Nigerian and one American, have won the MacArthur Foundation's 100&Change competition for their network to catch the next disease with pandemic potential.
Uche Medoh
For solving a 50-year mystery by uncovering the machinery behind BMP, a molecule with protective effects against various disorders, Uche Medoh is the winner of the 2025 Science & SciLifeLab Prize for Young Scientists.
🎉 Learn more about the work: https://scim.ag/4qVpK1a
50 % Cloud Restaurant, Yunnan, China
50 % Cloud Restaurant, Yunnan, China
50 % Cloud Restaurant, Yunnan, China
50 % Cloud Restaurant, Yunnan, China
50 % Cloud Restaurant, Yunnan, China
Cheng Chung Design transformed artist Luo Xu’s red-brick installation into a restaurant and art lounge. Its organic arches, skylights and flowing brick forms merge architecture, nature and art into a unique multi-sensory dining experience.
My 11-year-old sitting with her pile of Halloween candy, sorting it into a bar graph
We have progressed from data collection to data analysis.
Nice to see he’s bringing a new album out.
Achira is growing! We’re looking for talented software engineers, ML research engineers, and AI/ML scientists to join our team in building foundation simulation models to power the future of drug discovery.
Apply at achira.ai
I see that @kelbadry.bsky.social has won a MacArthur Foundation fellowship (Genius award)! Congratulations 🧪🔭
www.nytimes.com/2025/10/08/a...
"The Internet has Google. Now biology has MetaGraph. Detailed today in Nature1, the search engine can quickly sift through the staggering volumes of biological data housed in public repositories." 🧪 www.nature.com/articles/d41... anyone try this? What's it like?
Immunity researchers win the 2025 Nobel Prize in Physiology or Medicine
Immunity researchers win the 2025 #NobelPrize in Physiology or Medicine
Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi receive the prize for understanding how the immune system is kept in check. Read more: cen.acs.org/people/nobel...
#chemsky #immunosky 🧪
💸 🐦 🧪
Very happy this paper got accepted to NeurIPS 2025 as a Spotlight! 😁
Main takeaway: In mechanistic interpretability, we need assumptions about how DNNs encode concepts in their representations (eg, the linear representation hypothesis). Without them, we can claim any DNN implements any algorithm!
I’m not sure the linked in crowd is getting my snark about Virtual Cells 😄🫣
www.linkedin.com/posts/anneca...
This week's #RDKit blog post shows how to create simple protein--ligand interaction diagrams.
I think there's potential to take this a bit further...
greglandrum.github.io/rdkit-blog/p...
Jerusalem is an amazing city!
Our new workflow maps whole human fallopian tubes at single-cell resolution. In healthy FTs, we detected (many) STIC precancerous lesions.
We can also simulate virtual sectioning as done in the clinic and show how current protocols undersample FTs.
More here:
www.biorxiv.org/content/10.1...
At 15 years old, Owen Cooper becomes the youngest male acting winner in #Emmys history.
Congratulations
🧬 PFAS change gene activity
A new study of US firefighters shows some PFAS chemicals alter how genes work, linking them to cancers, autoimmune disease, and neurological disorders.
🔗 www.theguardian.com/environment/...
#SciComm #PFAS #Health 🧪
My talk at Accelerating Bio-Innovation gives a flavor for how cell-based images are propelling new treatments:
www.youtube.com/watch?v=kP-G...
My first post and I would like to plug my project - pharmacophore-toolkit. I thought others in the #cheminformatics, #molecularmodeling, #drugdiscovery, or the #chemsky #compchem community would find it helpful. github.com/tlint101/pha...
New Practical Cheminformatics Post
patwalters.github.io/Three-Papers...
Barack Obama encourages young men to have more diverse friend groups:
“I had a gay professor in college […] who became one of my favorite professors and was a great guy and would call me out when I started saying stuff that was ignorant. You need that to show empathy and kindness.”
