🧬🔎 Deep dive into plant #TransposableElements
❓ If you identify all autonomous #TEs, you will automatically also have all non-coding derivates, right? Right?
Well, no! Not even close. Check out here, how much you are missing:
📚 www.biorxiv.org/content/10.6...
#TEsky
The School of Biosciences at University of Birmingham is recruiting FIVE Assistant/Associate Profs in areas including fungal biology, plant science and bioengineering. Full details below 🍄🌾🧬🧫
Totally agree! I see increasing SI size as a symptom of problematic shifts in publishing norms in the last few decades. Emphasis on chasing impact factors & novelty/splash means every paper has to be a bigger & bigger story, and there's disincentive to space out the content
Possibly once councils meet that some of these (especially the single digit) will turn into NOAs eventually. Its not possible to plan anything on 'eventually' - projects/labs just stagnate because you don't want to hire, put out resources only to find out the grant won't be funded.
Please check out our new preprint! Using single cell analysis paired with HCR to visualize transcript localization we have identified cell and tissue-specific expression of various genes encoding tubulins, kifs, and dyneins during neural crest development!
"SHIT"
"FUCK"
"NO"
"FUCK"
"SHIT"
"FUCK"
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302
The data is in: the NIH goalposts have shifted.
What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.
Another manifestation of how HHS policies have led to fewer awards and less science.
Another really interesting #SciHis Story by @asimovpress.bsky.social.
Goes to show that there are interesting and curious stories and facts in everything - even little things like Agar that seem simple and straightforward.
www.asimov.press/p/agar
#ScienceHistory #MolecularBiology #Agarose #Seaweed
Ugh no? Unless it’s just me living under a rock……
On one hand I am really excited to try running kallisto using GPUs and do 50 sec/sample; on the other hand I am very bad at remembering how to submit GPU jobs on the cluster. 😅
Paging senior graduate students! Apply to present your research during the Salk Discover symposium and network with potential collaborators or faculty advisors. Application deadline extended to March 16.
More info: www.salk.edu/about/our-co...
Submitted a Infrastructure and facility ticket. I was like “WTF”…..
We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !
Pls re-post: My department @oxfordbiochemistry.bsky.social are recruiting for several new faculty positions (links below). Broad search in molecular biology/biochemistry, across prokaryotes and eukaryotes. Interested in understanding life at the molecular level, this job might be for you!
1/n
Re-upping this post. If you are going out tomorrow, be loud and clear.
Do you do amplicon sequencing to figure out how many mutations you have?
How many rounds of mutagenesis selection do you do?
Current NIH leadership want you to think they are using rigorous, consistent & scientific processes to screen studies to align them with agency priorities.
But the process that they have put down on paper is a sham.
It’s important to know NIH is not following its own guidance. Here’s why:
🧵1/
Postdoc told me he saw a mouse in the lab........🫠
How do people do error-prone PCR nowadays? (for directed evolution)
I'm thinking abt experiments to tune binding preference of TFs w/o affecting transcriptional activation or the core DNA binding motif.
Screenshot show 6 plasmid maps, 2 of them are flagged mismatch, while the rest of the 4 are marked as perfect match.
New interface of plasmidsaurus has been making my life easier.
Re-upping this post from a year ago. To invest in basic research is to invest in a better future for everyone.
You know, everyone deserves a better future, not just billionaires or whoever owns stocks of AI companies.
Here’s a full draft of the upcoming second edition of my “Data Visualization: A Practical Introduction”: socviz.co
The nuclear winter continues
Our work on #hornwort #pyrenoids is finally out in @science.org! 🎉 We uncovered how hornworts pack their Rubisco into pyrenoids and successfully recreated them in Arabidopsis. A key step toward engineering more efficient photosynthesis in crops @btiscience.bsky.social www.science.org/doi/10.1126/...
An unconventional Rubisco small subunit underpins the CO2-concentrating organelle in land plants www.science.org/doi/10.1126/... @science.org
From writing emails to committing war crimes, all in an LLM package deal.
$1B per day is about $42 million per hour. About 30 min worth of that spending can fund my lab for my ENTIRE career (~20 3-year NSFs or ~10 5-year R01s). Please wrap your head around that.
If you use Grammarly to check grammar you need to stop using it. I imagine most of us are not on board with LLM necromancy or whatever the heck this is.
