Jonas Neher (@jonasneher)

Welcome to the institute and department, Alena! 🎉

03.03.2026 17:07 👍 1 🔁 0 💬 0 📌 0

Very interesting study demonstrating the impact of improving vascular health on Alzheimer’s pathology!

20.02.2026 09:42 👍 2 🔁 0 💬 0 📌 0

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism - Nature Communications TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficac...

📢 Our latest work is now in press at @natcomms.nature.com! A great collaboration with the Schultze lab @dzne.science & Denali Therapeutics, to identify molecular and functional changes associated with TREM2 signalling in microglia, with implications for TREM2 agonism.. www.nature.com/articles/s41...

04.02.2026 15:42 👍 15 🔁 5 💬 0 📌 0

Implication: Current amyloid-PET may underestimate the most damaging Aβ burden, with direct consequences for clinical trials — arguing for complementary biomarkers and new imaging strategies targeting neurotoxic amyloid conformations.

17.01.2026 06:30 👍 2 🔁 0 💬 0 📌 0

Key points:
• Peripheral immune insults phenocopy TREM2/APOE risk, impairing microglial plaque engagement
• Non-compacted amyloid, not compact plaques, best predicts neuritic dystrophy
• These toxic amyloid states are invisible to standard amyloid-PET (e.g. [¹⁸F]flutemetamol)

17.01.2026 06:30 👍 1 🔁 0 💬 1 📌 0

Non-compacted, PET-insensitive amyloid states increase after systemic inflammation and predict neuritic damage across Aβ pathology models and Alzheimer patients Neuroinflammation is a key modulator of Alzheimer’s disease (AD) risk, yet the impact of non-genetic inflammatory risk factors – such as systemic inflammation – remains poorly defined. Building on our...

🧠🦠 New preprint out!

Systemic inflammation fundamentally reshapes amyloid plaques — shifting them toward non-compacted, filamentous Aβ states that strongly predict neuritic damage across mouse models and human Alzheimer’s disease.

#Alzheimers #Neuroimmunology #Microglia #Amyloid #PET #Inflammation

17.01.2026 06:30 👍 5 🔁 3 💬 1 📌 0

Important study for understanding the vascular mechanisms of dementia!

21.08.2025 06:23 👍 0 🔁 0 💬 0 📌 0

Very cool work! Glad to have been able to contribute.

26.07.2025 12:58 👍 3 🔁 0 💬 0 📌 0

Jonas Neher, Sarah Marzi, Susanne Kooistra and Renzo Mancuso at the microglia epigenetics symposium for the Glia conference 2025 in Marseille.

Good times discussing all things #epigenetics and #microglia at our symposium with this awesome group: @jonasneher.bsky.social, @kooistrasm.bsky.social, @mancusorenzo.bsky.social. And enjoying the sun and science at #glia2025 in Marseille, while hoping that fires can be contained.

10.07.2025 12:29 👍 10 🔁 1 💬 0 📌 0

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease
www.nature.com/articles/s41...

led by Michael Heneka, published in @natrevimmunol.bsky.social today

(MANY more authors listed and linked below)

10.12.2024 03:03 👍 145 🔁 51 💬 1 📌 4

Jonas Neher

Latest posts by Jonas Neher @jonasneher