Laurie Parker

Yah. feels like the jackpot has already started.

We posted a biorxiv preprint on structural bioinformatics, AlphaFold modeling & machine learning on predicting specificity of E3 ligase ring domains for different E2 enzymes. 1/4

Preprint: www.biorxiv.org/content/10.6...

Models/data (UbiqCore website): dunbrack.fccc.edu/ubiqcore

Today, Minneapolis had their annual Powderhorn Art Sled Rally. A community organized event that this time featured de-Icer sleds and bowling pins named for world leaders.

A very Minnesotan way to protest ICE. 😍🙌🏻

I don’t know enough about this stuff to know what is relevant here but just noticed that when scrolling through the HHS doc…

The October 2025 doc says that (some part of to all of?) it does not apply to grants from NIH, refers to this link for the NIH Grants Policy Statement: grants.nih.gov/grants/polic...

Delving into LLM-assisted writing in biomedical publications through excess vocabulary Large language models (LLMs) like ChatGPT can generate and revise text with human-level performance. These models come with clear limitations, can produce inaccurate information, and reinforce existing biases.

The appearance of large language models caused a drastic shift in the vocabulary of academic writing, according to an analysis in #ScienceAdvances of more than 15 million biomedical abstracts published from 2010 to 2024.

Learn more:

www.nih.gov/about-nih/ni...

Nice containerization of AlphaFold, Boltz, and Chai, and calculation of metrics (including our ipSAE score for protein-protein interactions). www.biorxiv.org/content/10.1...

Improving Oversight of Federal Grantmaking By the authority vested in me as President by the Constitution and the laws of the United States of America, and to improve the process of Federal

Well, this is a huge Executive Order power grab...

www.whitehouse.gov/presidential...

1/3

It looks like a giant’s weird arm hair

With boost to NIH budget, Senate panel rejects Trump’s plan to slash agency Republicans on spending committee push back against proposed reorganization and overhead cuts

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

Trump Administration Scraps Effort to Pause Health-Research Funding The administration halted and then restarted billions in new research grants flowing from the National Institutes of Health.

Russell Vought wanted to shut down all extramural grants from NIH in this current fiscal year, putting stop to ALL research across the US. Someone in the White House had better sense. But Vought is a dangerous man, who will stop at nothing to destroy science in America. www.wsj.com/politics/pol...

This NIH grant Multi-Year Funding ploy really makes you wonder what equally obscure and equally harmful stuff Vought is advancing across all the other functions of federal government, doesn’t it?

This is just so screwed up.

Odds of winning NIH grants plummet as new funding policy and spending delays bite Funding multiyear grants up front will sharply cut number of investigators receiving awards

Researchers’ chances of winning a grant from the National Institutes of Health have dropped under a new policy. scim.ag/4f7uew2

Hahah it helped explain to my lab how it means they will be able to fund way fewer projects moving forward.

💯

Where “you” in this scenario is the NIH institute leadership and your monthly rent is the annual budget for a given grant.

It’s like if your landlord made you escrow your full lease period’s rent upfront. You would not then have money available to you to buy other stuff that whole time. You’d have way less available for groceries and would have to get very austere in any spending choices you make going forward.

This 4th percentile funding cutoff for the NCI is so very catastrophic. Assuming a 4th percentile payline corresponds to a ~5% success rate, it would take 27 grant submissions to have an 80% chance of getting just one funded. At the current submission cap of 6 apps as PI/year that means 4.5 years

🤮

NIH staff are being required to fully fund ~ 50% of their grants. This means that all 4 years of an award will be paid out of this appropriation. This will help them get the appropriated funds spent, but will mean they can only fund (1/2 + 1/4*1/2) = 5/8 has many grants as they would have otherwise.

Multi-year funding at NIH: The Quickening I have apparently missed some major NIH moves that are related to my thoughts about the Multi-Year Funded Research Project Grant (RF1) mechanism. It turns out that this strategy of multi-year fundi…

Multi-year funding at NIH: The Quickening drugmonkey.wordpress.com/2025/07/23/m...

"NIH has ..implemented a new policy requiring that at least one-half of the remaining funds for competing research project grants (RPGs) in FY 2025 be used to upfront fund RPG competing awards. Upfront funding provides the funding for all years of the approved project period .. from one fiscal year"

Talk about your grant lotteries. Earn a 4%ile for a chance at a four year award....or bupkis. whee.

The 4th percentile… JFC

There is a rally on MONDAY at 4:30 PM to stand up for NIH. Please join.

Many NIH employees signed the Bethesda Declaration, objecting to the destruction of NIH. The Trump NIH Director asked the signers to meet. The rally follows that meeting, in support.

actionnetwork.org/ev...

Had such a good time at aps2025.org, so good to see everyone! A real community.

💯

I started reading DrugMonkey when I was NIGMS Director. I will impressed with his command of NIH policies and practices and his clear, direct voice to scientists and to NIH.

We started the NIGMS Feedback
Loop blog (the first IC director-written blog) in large parts because of his example.

1/n