Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...
Hey I did a fun thing with @warren.senate.gov about breaking up giant healthcare conglomerates
Successful day today at the @asbmb.bsky.social Capitol Hill Day. Great conversations with several offices. We have received great engagement. Appreciate their time and willingness to speak with us. Thank you to ASBMB for arranging over 120 meetings today with congressional representatives staff.
Check out our new review on binder discovery! In a fast-moving world, here are some thoughts we have in the moment.
Congrats @jzy2799.bsky.social and Eddy!!
www.sciencedirect.com/science/arti...
Original (left) and corrected (right) Fig. 4a in the paper https://www.nature.com/articles/s41586-026-10305-0 showing the chemical structures of amino acids (only the right one) the left figure is just an embarrassment
I wonder... 🤔🤔🧪 #chemsky
a) what program did the authors use to make the original (left) figure in the paper? Wild guess, ChatGPT
b) how such high school science level of disgrace pass peer review in @nature.com?
Note this was Fig.4.a NOT in SI
www.nature.com/articles/s41...
New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function.
www.nature.com/articles/s41...
@qedscience.bsky.social
Silvia's simulations showed that while all epitopes expose Sia for binding, Siglec-6 recognises and binds only GM1 because of a key interaction with the membrane through W127 and K126, which orientates the V-set domain to bind the Sia through Arg122 and the terminal Gal to the C-C' loop 😎
Wee thread 🧵⬇️ on our new #glycotime with @siglecdude.bsky.social John Klassen and @glycocode.bsky.social 🥳 where we show Siglecs as molecular precision tools, able to recognise sialylated glycans with surgical precision in their natural environment, not bad for a lectin! 😎
doi.org/10.1038/s420...
I was sad to learn that my postdoctoral mentor, David Botstein, died yesterday. I started with David as a postdoc in 1998, and he had a profound effect on both my life and scientific career. He was a giant in the field of genetics, making seminal contributions in both yeast and human genetics. 1/
A 3D-styled pie chart illustrating the distribution of Research and Development (R&D) resources based on the NSF NCSES National Patterns of R&D Resources: 2022-23 Update. The chart is divided into six segments, listed here in descending order of their financial contribution: Federal Govt: The largest segment, shown in dark blue, accounts for 51% of the total, valued at $39.5 B. Higher Ed. – Institutional: A light coral segment accounting for 23%, valued at $18.2 B. Non-profit at Research Institutes: A dark red segment accounting for 8%, valued at $6.1 B. Higher Ed. – Direct Philanthropy: A bright red segment accounting for 7%, valued at $5.8 B. Business: A grey segment accounting for 7%, valued at $5.2 B. Non-Federal Govt: The smallest segment, shown in light blue, accounting for 4%, valued at $3.2 B.
Here's a chart showing who funds basic research in the US. It's easy to tell that private funding cannot make up for significant cuts to government funding.
The mass range of tandem mass spectra can be categorized into three main regions. For glycopeptides, the lower mass range contains mainly oxonium ions, the middle range contains mainly peptide fragments, and the high range contains charge-reduced fragments. All regions contain valuable fragment ion information, but they can only be simultaneously accessed by breaking the 5–10–15 rule.
MS/MS scan range can be an afterthought that doesn't receive attention in method design, but improper settings can affect experimental outcomes. This is especially true in glycoproteomics.
A #glycotime thread about a new #JASMS paper on this idea from @riley-research.bsky.social
1/10
Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.
The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇
NIH is not issuing awards. You may think that it's because they it is coming up with new directions of research...The apposite is true.
Here is a graph showing how many fewer new funding opportunities that NIH has posted over time.
-91%, a trend that started on Jan 2025.
The Glycomics Core at Beth Israel Deaconess Medical Center is looking for a Postdoctoral Research Fellow with LC-MS/MS proteomics/glycoproteomics experience. For more information check: research.bidmc.org/ncfg/careers...
#proteomics #glycomics #glycoproteomics #lcms
Get to know biomedical researchers @stanfordbiosci.bsky.social @stanfordchemistry.bsky.social @stanford-chemh.bsky.social through our new “walk with me” series
stanmed.stanford.edu/we-are-stanf...
It’s finally out! Together with @embopress.org and
@reviewcommons.org, we conducted a structured side-by-side comparison of human peer review and our AI scientific review (see thread 👇👇👇🔥).
Read the paper here: link.springer.com/article/10.1...
A pleasure doing this with the great Thomas Lemberger
@tlemberger.bsky.social and Niv Samuel Mastboim
@nivsm.bsky.social
(1/5) How does glioblastoma maintain its immense heterogeneity? 🧠 Two new companion papers from the Bhaduri Lab @UCLA now on @bioRxiv offer a lineage-resolved view of GBM hierarchies. Let’s dive in! 🧵👇
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.1...
Our latest work on fluorescent probes for imaging infections in vivo is out. Check it out!
www.biorxiv.org/content/10.6...
Twitter/X "promotes conservative content and demotes posts by traditional media...algorithm substantially shifts attitudes towards more conservative opinions" www.nature.com/articles/s41...
Ribosomal RNA expansion segments mediate the oligomerization of inactive animal ribosomes
www.science.org/doi/full/10....
From Erin Schuman's lab @erin-schuman.bsky.social
#RNAbiology
NIH funding rate per applicant dropped 38% in FY2025 vs 2022, from 27.1% to 16.7%
Here's a breakdown by career stage. Why FY2022 vs FY2025?
• FY2022 was first FY with budget passed and administered by Biden
• FY2025 budget was in CR until 3/15/2025, so budget and most grants were under the Trump WH
Upcoming Gordon Research Conference on ENDOTHELIAL CELLS Spain (July 5-10, 2026).The latest breaking topics in vascular biology focused on endothelial cells will be featured. Open slots reserved for oral presentations. Register early to reserve your spot. www.grc.org/endothelial-...
Now THAT's a headline.
"The U.S. spent $30 billion to ditch textbooks for laptops and tablets: The result is the first generation less cognitively capable than their parents"
fortune.com/2026/02/21/l...
“cathepsin K…uniquely degrades cell-surface mucins, proteoglycans, and polysialylated glycoproteins, and…reduces total glycocalyx thickness…a promising starting point for the development of a glycocalyx-debulking enzyme for cancer therapeutics.” #glycotime @carolynbertozzi.bskyverified.social 👏
We are looking for two exceptional Research Assistants!
1) Experimental, to drive forward quantitative studies of transcription factor function in development
2) computational, to develop and apply cutting-edge deep learning models of gene regulation.
Links below
Started this project years ago, but now everything is deposited on @addgene.bsky.social and a short @protocolsio.bsky.social is online. Try it out to make your own (cheap) homemade nuclease/Benzonase!
dx.doi.org/10.17504/protocols.io.261ged7xov47/v2
Thank you @jcoker10.bsky.social and Michael Lim!
Happy to contribute to this Science Robotics perspective led by Raman Lab postdoc Dr. Ronald Heisser. We highlight how fostering relationships between the disability and soft #robotics communities could spark innovations that benefit society:
www.science.org/doi/10.1126/...
“The best that I can do in terms of making the next breakthrough or discovery is not to do it by myself, but to enable other scientists to do it”
— Jennifer Doudna
www.forbes.com/sites/amyfel...
