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Steve Wise

@granularprefrontal

Retired neuroscientist, author, pickleball player

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01.12.2023
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Latest posts by Steve Wise @granularprefrontal

Jeff Bezos

12.02.2026 17:20 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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Genetic Data From Over 20,000 U.S. Children Misused for β€˜Race Science’ The National Institutes of Health failed to protect brain scans that an international group of fringe researchers used to argue for the intellectual superiority of white people.

The National Institutes of Health promised to protect children’s sensitive data in a federally funded project to track brain development. After it failed to do so, fringe researchers co-opted the children’s data, giving fodder for racist claims on social media and white nationalist message boards.

28.01.2026 19:40 πŸ‘ 66 πŸ” 39 πŸ’¬ 7 πŸ“Œ 5
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Rethinking the centrality of brain areas in understanding functional organization - Nature Neuroscience Parcellation of the cortex into functionally modular brain areas is foundational to neuroscience. Here, Hayden, Heilbronner and Yoo question the central status of brain areas in neuroscience from the ...

A must-read review. It argues that brain areas are only one of several organizing principles and are not especially central, given their weak correspondence to function. Cytoarchitecture and connectivity are a starting point, not the endpoint.
www.nature.com/articles/s41...
#neuroscience

23.12.2025 17:20 πŸ‘ 114 πŸ” 29 πŸ’¬ 3 πŸ“Œ 1
Top left: Illustration showing the location of Utah arrays implanted into FPC of M1 (32 channels, blue) and M2 (64 channels, red); poststudy analysis confirmed both arrays implanted in the most rostro-lateral portion of FPC, with the entire array located rostral to the anterior tip of Principal Sulcus. Top right: Choice-aligned spectrogram showing a strong gamma frequency response (top). Array maps showing choice responses across the arrays implanted in M1 (blue) and M2 (red). Electrodes with significant gamma responses aligned to choices outlined in cyan. Red crosses indicate reference electrodes. Bottom left: Example spectrograms showing choice-aligned activity recorded from FPC following high-frequency stimulation (upper) or in the absence of stimulation (lower). Spectrogram calculated by averaging over the fifth to eighth trials after stimulation. Nonstimulation spectrogram calculated from the average spectrograms of trials from the last four trials of four nonstimulated blocks (i.e., same relative block epoch). White box indicates the 400 ms period used for further analysis. Bottom right: Illustration of the trials included in the analysis of changes in LFP activity recorded from FPC caused by electrical microstimulation. In stimulation blocks, the 10 trials before and 10 trials after the poststimulation block change were included (white box). In nonstimulation blocks a corresponding window of trials was selected.

Top left: Illustration showing the location of Utah arrays implanted into FPC of M1 (32 channels, blue) and M2 (64 channels, red); poststudy analysis confirmed both arrays implanted in the most rostro-lateral portion of FPC, with the entire array located rostral to the anterior tip of Principal Sulcus. Top right: Choice-aligned spectrogram showing a strong gamma frequency response (top). Array maps showing choice responses across the arrays implanted in M1 (blue) and M2 (red). Electrodes with significant gamma responses aligned to choices outlined in cyan. Red crosses indicate reference electrodes. Bottom left: Example spectrograms showing choice-aligned activity recorded from FPC following high-frequency stimulation (upper) or in the absence of stimulation (lower). Spectrogram calculated by averaging over the fifth to eighth trials after stimulation. Nonstimulation spectrogram calculated from the average spectrograms of trials from the last four trials of four nonstimulated blocks (i.e., same relative block epoch). White box indicates the 400 ms period used for further analysis. Bottom right: Illustration of the trials included in the analysis of changes in LFP activity recorded from FPC caused by electrical microstimulation. In stimulation blocks, the 10 trials before and 10 trials after the poststimulation block change were included (white box). In nonstimulation blocks a corresponding window of trials was selected.

What's the role of #FrontopolarCortex (FPC) in evaluating alternative goals? @markboxf.bsky.social &co show that FPC activity tracks the value of #counterfactual rules via gamma & beta bursts; targeted FPC stimulation alters both neural signals & #DecisionMaking @plosbiology.org πŸ§ͺ plos.io/4ppd5lL

19.11.2025 17:31 πŸ‘ 7 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
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Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

"An emotional research team became tearful as they described how data shows the disease was slowed by 75% in patients...Prof Tabrizi says this gene therapy 'is the beginning' and will open the gates for therapies that can reach more people."πŸ§ͺβš•οΈ

24.09.2025 18:21 πŸ‘ 299 πŸ” 66 πŸ’¬ 7 πŸ“Œ 15

Since start of 2025, as compared to the same period in 2024, Johns Hopkins has received 40% fewer federal awards, a decline of ~50% in research funding, a reduction of $500 million.
University wide, international graduate student enrollment is down by 8% since last year.

23.09.2025 11:44 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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Why I’m Resigning from the NSF and Library of Congress I cannot participate in systems that require dishonesty as the price of belonging.

"For me, the answer now lies in refusal, the withdrawal of participation from systems that require dishonesty as the price of belonging."

Today I am resigning from the National Science Board and the Library of Congress Scholars Council.

I wrote about my decision in TIME.

time.com/7285045/resi...

13.05.2025 11:19 πŸ‘ 17208 πŸ” 5956 πŸ’¬ 475 πŸ“Œ 508
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Federal budget cuts threaten the work of neuroscientist with Martin County roots | Opinion Sarah Heilbronner is a proud product of Martin County schools. However, federal budget cuts threaten important work she's doing in brain research.

Neuroscientist Sarah Heilbronner is a proud product of Martin County schools in Florida 🌴. However, federal budget cuts threaten important work she's doing in brain research. πŸ§ͺ🏠
@srheilbronner.bsky.social
www.tcpalm.com/story/opinio...

02.03.2025 15:11 πŸ‘ 984 πŸ” 270 πŸ’¬ 23 πŸ“Œ 7
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Financial peril could doom a famed New York paleontological institute β€œExceptional” fossil collections housed by the Paleontological Research Institute risk being orphaned

β€œThe devastation of losing something like [the Paleontological Research Institution] is monumental … It can never be replaced.” scim.ag/4ibbAUB

20.02.2025 21:25 πŸ‘ 113 πŸ” 47 πŸ’¬ 0 πŸ“Œ 7
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Guest column: Why science funding matters to Indiana Last week the government cut β€œindirect costs” to universities and medical centers, which cover shared resources like buildings, utility bills, computer networks, and support staff. Indiana will los…

I wrote a column in my hometown newspaper about the importance of keeping SCIENCE FUNDING in our community πŸ§ͺ
More soon about the power of writing back HOME 🏠
www.chicagotribune.com/2025/02/15/g...

18.02.2025 12:33 πŸ‘ 204 πŸ” 73 πŸ’¬ 5 πŸ“Œ 5
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Memory and the Brain: Using, Losing, and Improving Memory and the Brain explores the fascinating psychology and neuroscience of human memory. Written by a world expert in the field, John P. Aggleton, this book covers learning and memory from the very ...

www.routledge.com/Memory-and-t...

16.12.2024 19:29 πŸ‘ 5 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Kudos to Matt Ainsworth and Juan Galeazzi who are joint first authors on our preprint (and fond remembrance to our dear departed colleague Mark Stokes, also co-author).

10.12.2024 12:46 πŸ‘ 4 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
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Column | Steve Cohen has stupid money, but this Juan Soto deal might be foolish Don’t despair over Juan Soto’s megadeal: The Mets and their big-spending owner will get what they deserve.

Column by Thomas Boswell | Don’t despair over Juan Soto’s megadeal: The Mets and their big-spending owner will get what they deserve.

10.12.2024 19:10 πŸ‘ 54 πŸ” 11 πŸ’¬ 10 πŸ“Œ 9
The title page of the special issue, which reads "Introduction to the special issue on visual cognition and visuomotor control: A tribute to Mel Goodale" The authors of the Intro are: Jody C. Culham, Gavin Buckingham, Monika Harvey, Irene Sperandio, Ingrid S. Johnsrude

The title page of the special issue, which reads "Introduction to the special issue on visual cognition and visuomotor control: A tribute to Mel Goodale" The authors of the Intro are: Jody C. Culham, Gavin Buckingham, Monika Harvey, Irene Sperandio, Ingrid S. Johnsrude

I feel so honored by the publication of this special issue of Neuropsychologia. Thanks so much to my friends and colleagues who put this together. And thanks to all the contributors. There are so many wonderful articles. I can't tell you how delighted I am. πŸ§ͺ🧠 www.sciencedirect.com/science/arti...

25.11.2024 18:55 πŸ‘ 215 πŸ” 48 πŸ’¬ 9 πŸ“Œ 5
β€˜Huge influx’ of neuroscientists migrates to Bluesky Daily neuroscience-related posts on the social-media platform this week have increased more than 400 percent, on average, compared with October.

Neuroscientists are flocking to Bluesky, but X still has ten times more users. My story on the migration, featuring @nicolecrust.bsky.social @russpoldrack.bsky.social @charan-neuro.bsky.social @therealdrdukes.bsky.social @wiringthebrain.bsky.social + more! www.thetransmitter.org/community/hu...

21.11.2024 17:14 πŸ‘ 86 πŸ” 23 πŸ’¬ 6 πŸ“Œ 4

hello neuroscientists! I am working on a story for @thetransmitter.bsky.social about the X to Bluesky migration and I would love to hear why you switched platforms (and what you make of bluesky so far). DM me or email me calli@thetransmitter.org if you'd like to comment for the piece. Thank you!

18.11.2024 16:50 πŸ‘ 74 πŸ” 36 πŸ’¬ 8 πŸ“Œ 2
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Thrilled that our paper on the role of the rat prelimbic cortex (PLC) in decision making is finally out! Three main findings are described in this thread

Co-authors: Jensen Palmer, Samantha White, and Kevin Chavez Lopez

doi.org/10.1523/JNEU...

18.11.2024 19:12 πŸ‘ 66 πŸ” 14 πŸ’¬ 3 πŸ“Œ 1
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26 years after Larry Swanson emphasized β€œthe amygdala is neither a structural or functional unit” we used sn-RNAseq to answer the question:

β€œWhat is the [primate] amygdala?”

Check out the preprint πŸ‘‡

www.biorxiv.org/content/10.1...

19.10.2024 17:58 πŸ‘ 35 πŸ” 22 πŸ’¬ 1 πŸ“Œ 4

I've been interested in this point for a long time. It would be valuable, I think, to explore it systematically, the way I imagine a sociologist might. For example, what are the career outcomes for student-generated vs. mentor-generated research? Maybe someone has already done something like that.

30.09.2024 17:30 πŸ‘ 2 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Understanding the Prefrontal Cortex: Selective advantage, connectivity, and neural operations (Oxford Psychology Series Book 53) eBook : Passingham, Richard: Amazon.co.uk: Books Understanding the Prefrontal Cortex: Selective advantage, connectivity, and neural operations (Oxford Psychology Series Book 53) eBook : Passingham, Richard: Amazon.co.uk: Books

#neuroskyence This book is available in ebook format at a discounted price in November.

www.amazon.co.uk/Understandin...

20.09.2024 19:02 πŸ‘ 13 πŸ” 6 πŸ’¬ 1 πŸ“Œ 0

Oxford University Press has made Chapter 1 of my book, Cortical Evolution in Primates, available free of charge: fdslive.oup.com/www.oup.com/...

23.08.2024 18:57 πŸ‘ 16 πŸ” 9 πŸ’¬ 0 πŸ“Œ 0

I'm retired now, but it is the activity I miss most. Because the reviewers are almost invariably wrong, it's usually more like a victory lap than an argument.

20.08.2024 18:22 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Despite Setback, Neuralink’s First Brain-Implant Patient Stays Upbeat Elon Musk’s first human experiment with a computerized brain device developed significant flaws, but the subject, who is paralyzed, has few regrets.

Elon Musk’s first human experiment with the computerized brain device Neuralink developed significant flaws. But Noland Arbaugh, who is paralyzed and the first patient to take part in the human clinical trial, said he has few regrets.

22.05.2024 19:09 πŸ‘ 13 πŸ” 2 πŸ’¬ 8 πŸ“Œ 4
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Toward a neuroscience of natural behavior One of the most exciting new developments in systems neuroscience is the progress being made toward neurophysiological experiments that move beyond si…

www.sciencedirect.com/science/arti...

08.04.2024 17:12 πŸ‘ 5 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
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Unleashing the power of DIY innovation in behavioral neuroscience Widespread adoption of open-source tools calls for more support and training.

Widespread adoption of open-source tools calls for more support and training.

By @alexxai.bsky.social and @marklaubach.bsky.social

www.thetransmitter.org/open-neurosc...

02.04.2024 13:20 πŸ‘ 6 πŸ” 5 πŸ’¬ 0 πŸ“Œ 1

i plan to move to Korea later this year, & will soon hire at all levels (students, postdocs, staff scientists, junior PIs) -

docs.google.com/document/d/1...

my lab in Japan will run till at least 2025. my job has been nothing but the dream job. but hopefully the above explains it.

#neuroscience

28.03.2024 01:31 πŸ‘ 45 πŸ” 34 πŸ’¬ 5 πŸ“Œ 3

Sounds like fun, good luck with the move!

28.03.2024 11:20 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0