Luis Rodriguez (@lurod8)

Redirecting

Congrats to Dr Sarah Bui and the Beers lab @westphillytough.bsky.social for this fantastic addition to our understanding of surfactant protein C processing! kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

05.03.2026 15:51 👍 0 🔁 0 💬 0 📌 0

Congrats to first author, Dr. Andrea Alber, co-senior-author Dr. Kostas Alysandratos, and all the team @crem-boston.bsky.social . For patients with pulmonary fibrosis this new human model system should help propel drug discovery and therapeutic development. #helpisontheway! #itsthecells!

01.02.2026 19:53 👍 3 🔁 1 💬 0 📌 0

Regulatory T cells protect against aberrant remodeling in a mouse model of pulmonary fibrosis Regulatory T (Treg) cells are well recognized for their role in immune regulation; however, their role in tissue regeneration is not fully understood.…

Congrats to @amurthy10.bsky.social and @westphillytough.bsky.social on this story supporting the important crosstalk between adventitial fibroblasts and tregs in pulmonary fibrosis. www.sciencedirect.com/science/arti...

30.12.2025 23:01 👍 1 🔁 1 💬 0 📌 0

Excited to help spread the word about the latest advances in stem cell research! #itsthecells!

03.10.2025 18:52 👍 4 🔁 1 💬 0 📌 0

Aberrant intermediate alveolar epithelial cells promote pathogenic activation of lung fibroblasts in preclinical fibrosis models - Nature Communications The direct contribution of aberrant epithelial cells to lung fibrosis is largely unknown. The authors use murine and human systems to identify how these cells activate fibroblasts, and how reciprocal signals cause them to enter a profibrotic state.

Announcing our latest publication, just out today
@NatureComms, advancing our understanding of interstitial lung disease. Congrats to co-senior authors Drs. Jeremy Katzen and Kostas Alysandratos and their teams @Penn @CReM_Boston. Check it out here: www.nature.com/articles/s41...

30.09.2025 22:14 👍 7 🔁 4 💬 0 📌 0

REGULATORY T CELLS PROTECT AGAINST ABERRANT REMODELING IN A MOUSE MODEL OF PULMONARY FIBROSIS Regulatory T (Treg) cells are well recognized for their role in immune regulation; however, their role in tissue regeneration is not fully understood. This study demonstrates such a role of Tregs in a published preclinical murine model of spontaneous pulmonary fibrosis (PF) expressing a human PF related mutation in the Surfactant Protein-C (SP-C) gene (SFTPCI73T). Genetic crosses of SP-CI73T mice with Foxp3GFP and Foxp3DTR lines were utilized to study Treg behavior during PF development. We found that FoxP3+Tregs accumulate during the transition from inflammation to fibrogenesis, peaking at 21-28 days after mutant SftpcI73T induction localizing to both perivascular and distal fibrotic lung regions. Diphtheria toxin mediated ablation of Tregs at 17 days worsened fibrosis and increased levels of TGFβ and inflammatory cytokines. Tregs expressed Th2 markers (Gata3+) and elaborated factors including amphiregulin (Areg) and Osteopontin (Spp1). Reductionist experiments showed that lung Tregs enhanced organoid formation when co-cultured with alveolar epithelial cells and adventitial fibroblasts, an effect size mimicked using Areg and Spp1 in combination. Our findings demonstrate that immune-mesenchymal-epithelial signaling crosstalk is present in the distal lung wherein Tregs play a protective role by limiting fibrosis and promoting tissue repair, highlighting their broader function beyond immune modulation in lung injury. ### Competing Interest Statement The authors have declared no competing interest. National Institutes of Health, https://ror.org/01cwqze88, 1R01HL145408, HL152970, HL007586, HL150226, 1K99HL171946

Check out the newest preprint from
the @westphillytough.bsky.social lead by @amurthy10.bsky.social exploring the important role of Regulatory T cells as modulators of fibrotic resolution! www.biorxiv.org/content/10.1...

06.07.2025 16:23 👍 1 🔁 1 💬 0 📌 0

Off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results An off-the-shelf stem cell therapy for type 1 diabetes continues to show positive results, according to a new study.

Truly amazing pluripotent stem cell clinical trial results for diabetes! “Off-the-shelf stem cell therapy for type 1 diabetes yields more positive results”. Also published in ⁦‪@NEJM‬⁩ this week. #helpisontheway!
www.statnews.com/2025/06/20/s...

21.06.2025 03:30 👍 8 🔁 3 💬 1 📌 1

As a diversity grant dies, young scientists fear it will haunt their careers The Trump administration defunded the National Institute of Health's MOSAIC grant program, which launched the careers of scientists from diverse backgrounds.

www.npr.org/sections/sho... Great story by NPR about this K99/R00 mass cancelation at the NIH

28.04.2025 17:13 👍 1 🔁 0 💬 1 📌 0

Luis Rodriguez

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