@mccreery
We study the cell nucleus and the tissue microenvironment, driving dynamic cell mechanics. Multiscale Bioengineering Lab at College of Engineering & Mathematical Sciences at the University of Vermont. mccreerylab.com
Excited to share our work on epithelial multilayering - identifying why stem cell stay in the basal layer and how and why differentiating cells move up. Great collab with @manningresearch.bsky.social and Niessen labs! Check out preprint and great summary below www.biorxiv.org/content/10.6...
You don't understand that's my emotional support bag of loose PCR tubes
Sleep matters for joint health!
In our new paper led by Dr Liz Rowlands, we studied sleep habits of 500,000 people. Osteoarthritis risk was highest with <6 hours of nightly sleep and significantly increased by shift work.
acrjournals.onlinelibrary.wiley.com/doi/10.1002/...
Interested in the biophysics of organoids? We just published a review in Dev Cell—take a look! dlvr.it/TPyTb8 #Organoids #Biophysics
Appreciate Quanta for shining a light on our joint work with Simon Gsell, Sham Tlili (@shamtlili.bsky.social), and Matthias Merkel (@merkellab.bsky.social).
💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ
See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...
Amazing to have our work finally out!!! 😍🤩😍
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells @natcellbio.nature.com @sarawickstrom.bsky.social @akistubb.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Our paper is out in Nature Cell Biology! 🚀 Growth factors, mechanical forces, and osmotic stress work together to guide stem cell differentiation. Delighted to see these discoveries out in the world 🔥
How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.
Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and what role does #mechanobiology play here? Learn more in our recent review by fantastic Sarah Henretta, now out in NPJ - Biological Physics and Mechanics, open access: doi.org/10.1038/s443...
Cool new method to integrate mechanics and transcriptomics, can’t wait to try it out 🤓 Congratulations Adrien @halloulab.bsky.social & team!
Our review "Measuring and manipulating mechanical forces during development" is now published in Nature Cell Biology!
#Mechanobiology #DevelopmentalBiology
UVM is now a Carnegie R1 institution! This achievement reflects decades of dedication to cutting-edge research, innovation, and excellence. With over $260M in funding (FY24) and groundbreaking projects, we're on the course for an even more ambitious future! #UVMresearch
